{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:03:25Z","timestamp":1787169805233,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>We report an unusual presentation of a 10-month-old girl with left eye (LE) redness and watering. Evaluation showed an iris vascular lesion and lens opacity in her LE. Child underwent USG B-scan and ultrasound biomicroscopy, by which an extensive mass lesion arising from iris and ciliary body with absent calcification was revealed. Following extensive evaluation, child underwent cataract extraction and trans-scleral total excision of the mass lesion. Histopathology proved it as juvenile xanthogranuloma (JXG) with vascular proliferation. JXG is a rare benign self-limiting dermatologic disorder affecting mainly infants and small children. Ocular lesions are the most common extracutaneous manifestation. Cataract in JXG is less frequently reported. This case is reported due to its rarity and as it presented solely as an intraocular lesion with combined diffuse infiltration into ciliary body and cataract which is unusual. Early recognition and systematic approach helped in sight saving and organ salvaging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/tjo.tjo_35_21","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T05:19:43Z","timestamp":1636521583000},"page":"117-120","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Unusual presentation of a vascularized iris lesion in an infant"],"prefix":"10.4103","volume":"13","author":[{"given":"Sasikala Elizabeth","family":"Anilkumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parag K.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. R.","family":"Saravanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhakrishnan","family":"Shanthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narendran","family":"Kalpana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-22-20240830","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ajoc.2017.09.004","article-title":"Juvenile xanthogranuloma involving concurrent iris and skin: Clinical, pathological and molecular pathological evaluations","volume":"9","author":"Meyer","year":"2018","journal-title":"Am J Ophthalmol Case Rep"},{"key":"R2-22-20240830","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1542\/peds.4.3.349","article-title":"Nevoxantho-endothe- lioma with ocular involvement","volume":"4","author":"Blank","year":"1949","journal-title":"Pediatrics"},{"key":"R3-22-20240830","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1016\/j.ophtha.2015.06.009","article-title":"Juvenile xanthogranuloma involving the eye and ocular adnexa: Tumor control, visual outcomes, and globe salvage in 30 patients","volume":"122","author":"Samara","year":"2015","journal-title":"Ophthalmology"},{"key":"R4-22-20240830","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jaapos.2014.01.007","article-title":"Successful treatment of juvenile xanthogranuloma using bevacizumab","volume":"18","author":"Ashkenazy","year":"2014","journal-title":"J AAPOS"},{"key":"R5-22-20240830","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ophtha.2011.07.059","article-title":"Clinical survey of 3680 iris tumors based on patient age at presentation","volume":"119","author":"Shields","year":"2012","journal-title":"Ophthalmology"},{"key":"R6-22-20240830","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S1085-5629(99)80017-0","article-title":"Update on juvenile xanthogranuloma: Unusual cutaneous and systemic variants","volume":"18","author":"Chang","year":"1999","journal-title":"Semin Cutan Med Surg"},{"key":"R7-22-20240830","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/0002-9394(65)92808-4","article-title":"Ocular lesions of juvenile xanthogranuloma. Nevoxanthoedothelioma","volume":"60","author":"Zimmerman","year":"1965","journal-title":"Am J Ophthalmol"},{"key":"R8-22-20240830","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/08820530500351769","article-title":"Glaucoma in juvenile xanthogranuloma","volume":"21","author":"Vendal","year":"2006","journal-title":"Semin Ophthalmol"},{"key":"R9-22-20240830","doi-asserted-by":"crossref","first-page":"673","DOI":"10.4103\/0301-4738.119336","article-title":"Cataract surgery in juvenile xanthogranuloma: Case report and a brief review of literature","volume":"61","author":"Muralidhar","year":"2013","journal-title":"Indian J Ophthalmol"},{"key":"R10-22-20240830","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4103\/ojo.OJO_1_2017","article-title":"Pigmented ciliary body medulloepithelioma in a newborn infant","volume":"10","author":"Shah","year":"2017","journal-title":"Oman J Ophthalmol"},{"key":"R11-22-20240830","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0039-6257(05)80046-3","article-title":"Chorioretinal, iris, and ciliary body infiltration by juvenile xanthogranuloma masquerading as uveitis","volume":"39","author":"DeBarge","year":"1994","journal-title":"Surv Ophthalmol"}],"container-title":["Taiwan Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/tjo.tjo_35_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:12:36Z","timestamp":1787166756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/tjo.tjo_35_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/tjo.tjo_35_21","relation":{},"ISSN":["2211-5056"],"issn-type":[{"value":"2211-5056","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}