{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:38:44Z","timestamp":1790642324508,"version":"4.1.0"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Taiwan J Ophthalmol"],"published-print":{"date-parts":[[2018]]},"DOI":"10.4103\/tjo.tjo_37_18","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T05:55:46Z","timestamp":1544680546000},"page":"196","source":"Crossref","is-referenced-by-count":8,"title":["Knudson to embryo selection: A story of the genetics of retinoblastoma"],"prefix":"10.4103","volume":"8","author":[{"given":"Vikas","family":"Khetan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vrushali","family":"Athavale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/2211-5056.244532-1","first-page":"15021","volume-title":"Retinoblastoma","author":"Dimaras","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"key-10.4103\/2211-5056.244532-2","first-page":"197","volume-title":"Genetics and molecular diagnostics in retinoblastoma \u2013 An update","author":"Soliman","year":"2017","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"key":"key-10.4103\/2211-5056.244532-3","first-page":"33","volume-title":"The genomic landscape of retinoblastoma: A review","author":"Th\u00e9riault","year":"2014","journal-title":"Clin Exp Ophthalmol"},{"key":"key-10.4103\/2211-5056.244532-4","first-page":"654","volume-title":"Historic review of retinoblastoma","author":"Albert","year":"1987","journal-title":"Ophthalmology"},{"key":"key-10.4103\/2211-5056.244532-5","unstructured":"Mukherjee S. The Gene. India: Penguin Books; 2016."},{"key":"key-10.4103\/2211-5056.244532-6","first-page":"820","volume-title":"Mutation and cancer: Statistical study of retinoblastoma","author":"Knudson","year":"1971","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.4103\/2211-5056.244532-7","first-page":"501","volume-title":"Genetic origin of mutations predisposing to retinoblastoma","author":"Cavenee","year":"1985","journal-title":"Science"},{"key":"key-10.4103\/2211-5056.244532-8","first-page":"115","volume-title":"Genetic sequences that predispose to retinoblastoma and osteosarcoma","author":"Dryja","year":"1986","journal-title":"Symp Fundam Cancer Res"},{"key":"key-10.4103\/2211-5056.244532-9","first-page":"283","volume-title":"Isolation of human chromosome 13-specific DNA sequences cloned from flow sorted chromosomes and potentially linked to the retinoblastoma locus","author":"Lalande","year":"1984","journal-title":"Cancer Genet Cytogenet"},{"key":"key-10.4103\/2211-5056.244532-10","first-page":"643","volume-title":"Ahuman DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma","author":"Friend","year":"1986","journal-title":"Nature"},{"key":"key-10.4103\/2211-5056.244532-11","first-page":"1394","volume-title":"Human retinoblastoma susceptibility gene: Cloning, identification, and sequence","author":"Lee","year":"1987","journal-title":"Science"},{"key":"key-10.4103\/2211-5056.244532-12","first-page":"18","volume-title":"Preimplantation genetic diagnosis for retinoblastoma: The first reported liveborn","author":"Xu","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"key-10.4103\/2211-5056.244532-13","doi-asserted-by":"crossref","unstructured":"Grossniklaus HE. Retinoblastoma. Fifty years of progress. The LXXI Edward Jackson memorial lecture. Am J Ophthalmol 2014;158:875-91.","DOI":"10.1016\/j.ajo.2014.07.025"},{"key":"key-10.4103\/2211-5056.244532-14","unstructured":"Kim JW, Mansfield NC, Murphree AL. Retinoblastoma. In: Schachat AP, editor. Ryan's Retina. 6th ed. Edinburgh: Elsevier; 2018. p. 2375-412."},{"key":"key-10.4103\/2211-5056.244532-15","first-page":"75","volume-title":"The clinical spectrum and treatment outcome of retinoblastoma in Indian children","author":"Shanmugam","year":"2005","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"key-10.4103\/2211-5056.244532-16","first-page":"5502","volume-title":"Structure of the human retinoblastoma gene","author":"Hong","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.4103\/2211-5056.244532-17","first-page":"5233","volume-title":"The retinoblastoma tumor-suppressor gene, the exception that proves the rule","author":"Goodrich","year":"2006","journal-title":"Oncogene"},{"key":"key-10.4103\/2211-5056.244532-18","first-page":"247","volume-title":"Molecular genetics of RB1 \u2013 The retinoblastoma gene","author":"Leiderman","year":"2007","journal-title":"Semin Ophthalmol"},{"key":"key-10.4103\/2211-5056.244532-19","first-page":"53","volume-title":"RB1 gene mutation up-date, a meta-analysis based on 932 reported mutations available in a searchable database","author":"Valverde","year":"2005","journal-title":"BMC Genet"},{"key":"key-10.4103\/2211-5056.244532-20","first-page":"446","volume-title":"Quantification of the paternal allele bias for new germline mutations in the retinoblastoma gene","author":"Dryja","year":"1997","journal-title":"Hum Genet"},{"key":"key-10.4103\/2211-5056.244532-21","first-page":"457","volume-title":"Statement on guidance for genetic counseling in advanced paternal age","author":"Toriello","year":"2008","journal-title":"Genet Med"},{"key":"key-10.4103\/2211-5056.244532-22","first-page":"779","volume-title":"Expression of recessive alleles by chromosomal mechanisms in retinoblastoma","author":"Cavenee","year":"1983","journal-title":"Nature"},{"key":"key-10.4103\/2211-5056.244532-23","first-page":"332","volume-title":"Genetic perspective of retinoblastoma: From present to future","author":"Jagadeesan","year":"2016","journal-title":"Indian J Ophthalmol","ISSN":"https:\/\/id.crossref.org\/issn\/0301-4738","issn-type":"print"},{"key":"key-10.4103\/2211-5056.244532-24","first-page":"63","volume-title":"Retinoblastoma in India: Microsatellite analysis and its application in genetic counseling","author":"Ramprasad","year":"2007","journal-title":"Mol Diagn Ther"},{"key":"key-10.4103\/2211-5056.244532-25","first-page":"547","volume-title":"Genetics and epigenetics of human retinoblastoma","author":"Benavente","year":"2015","journal-title":"Annu Rev Pathol"},{"key":"key-10.4103\/2211-5056.244532-26","first-page":"1363","volume-title":"Loss of RB1 induces non-proliferative retinoma: Increasing genomic instability correlates with progression to retinoblastoma","author":"Dimaras","year":"2008","journal-title":"Hum Mol Genet"},{"key":"key-10.4103\/2211-5056.244532-27","first-page":"1364","volume-title":"Loss of pRB causes centromere dysfunction and chromosomal instability","author":"Manning","year":"2010","journal-title":"Genes Dev"},{"key":"key-10.4103\/2211-5056.244532-28","first-page":"797","volume-title":"Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control","author":"Hernando","year":"2004","journal-title":"Nature"},{"key":"key-10.4103\/2211-5056.244532-29","first-page":"617","volume-title":"One hit, two hits, three hits, more.Genomic changes in the development of retinoblastoma?","author":"Corson","year":"2007","journal-title":"Genes Chromosomes Cancer"},{"key":"key-10.4103\/2211-5056.244532-30","first-page":"61","volume-title":"Inactivation of the p53 pathway in retinoblastoma","author":"Laurie","year":"2006","journal-title":"Nature"},{"key":"key-10.4103\/2211-5056.244532-31","first-page":"327","volume-title":"Characterisation of retinoblastomas without RB1 mutations: Genomic, gene expression, and clinical studies","author":"Rushlow","year":"2013","journal-title":"Lancet Oncol"},{"key":"key-10.4103\/2211-5056.244532-32","first-page":"329","volume-title":"Anovel retinoblastoma therapy from genomic and epigenetic analyses","author":"Zhang","year":"2012","journal-title":"Nature"},{"key":"key-10.4103\/2211-5056.244532-33","first-page":"155","volume-title":"Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma","author":"Greger","year":"1989","journal-title":"Hum Genet"},{"key":"key-10.4103\/2211-5056.244532-34","first-page":"1063","volume-title":"CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene","author":"Ohtani-Fujita","year":"1993","journal-title":"Oncogene"},{"key":"key-10.4103\/2211-5056.244532-35","first-page":"1018","volume-title":"Retinoblastoma has properties of a cone precursor tumor and depends upon cone-specific MDM2 signaling","author":"Xu","year":"2009","journal-title":"Cell"},{"key":"key-10.4103\/2211-5056.244532-36","doi-asserted-by":"crossref","unstructured":"McEvoy J, Flores-Otero J, Zhang J, Nemeth K, Brennan R, Bradley C, et al. Coexpression of normally incompatible developmental pathways in retinoblastoma genesis. Cancer Cell 2011;20:260-75","DOI":"10.1016\/j.ccr.2011.07.005"},{"key":"key-10.4103\/2211-5056.244532-37","first-page":"512","volume-title":"Gene expression profiling identifies different sub-types of retinoblastoma","author":"Kapatai","year":"2013","journal-title":"Br J Cancer"},{"key":"key-10.4103\/2211-5056.244532-38","first-page":"260","volume-title":"Genetics of retinoblastoma","author":"Mallipatna","year":"2016","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"key":"key-10.4103\/2211-5056.244532-39","first-page":"478","volume-title":"Dysmorphic phenotype and neurological impairment in 22 retinoblastoma patients with constitutional cytogenetic 13q deletion","author":"Baud","year":"1999","journal-title":"Clin Genet"},{"key":"key-10.4103\/2211-5056.244532-40","first-page":"582","volume-title":"Trilateral retinoblastoma","author":"Bader","year":"1980","journal-title":"Lancet"},{"key":"key-10.4103\/2211-5056.244532-41","first-page":"1829","volume-title":"Trilateral retinoblastoma: A meta-analysis of hereditary retinoblastoma associated with primary ectopic intracranial retinoblastoma","author":"Kivel\u00e4","year":"1999","journal-title":"J Clin Oncol"},{"key":"key-10.4103\/2211-5056.244532-42","first-page":"203","volume-title":"Bilateral retinoblastoma with ectopic intracranial retinoblastoma: Trilateral retinoblastoma","author":"Bader","year":"1982","journal-title":"Cancer Genet Cytogenet"},{"key":"key-10.4103\/2211-5056.244532-43","first-page":"454","volume-title":"Nonocular cancer in retinoblastoma survivors","author":"Abramson","year":"1976","journal-title":"Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol"},{"key":"key-10.4103\/2211-5056.244532-44","first-page":"45","volume-title":"A second primary tumor in a patient with retinoma","author":"Korswagen","year":"2004","journal-title":"Ophthalmic Genet"},{"key":"key-10.4103\/2211-5056.244532-45","first-page":"453","volume-title":"Screening children at risk for retinoblastoma.Consensus report from the American Association of Ophthalmic Oncologists and Pathologists","author":"Skalet","year":"2018","journal-title":"Ophthalmology"},{"key":"key-10.4103\/2211-5056.244532-46","first-page":"1555","volume-title":"Familial retinoblastoma: Fundus screening schedule impact and guideline proposal.A retrospective study","author":"Rothschild","year":"2011","journal-title":"Eye (Lond)"},{"key":"key-10.4103\/2211-5056.244532-47","unstructured":"Lohmann DR, Gallie BL. Retinoblastoma. Gene Reviews. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1452\/#!po=1.56250. [Last accessed on 2018 Mar 22]."},{"key":"key-10.4103\/2211-5056.244532-48","first-page":"55","volume-title":"In utero detection of retinoblastoma with fetal magnetic resonance and ultrasound: Initial experience","author":"Paquette","year":"2012","journal-title":"AJP Rep"},{"key":"key-10.4103\/2211-5056.244532-49","first-page":"430","volume-title":"Prenatal genetic diagnosis of retinoblastoma and report of RB1 gene mutation from India","author":"Shah","year":"2016","journal-title":"Ophthalmic Genet"},{"key":"key-10.4103\/2211-5056.244532-50","first-page":"2610","volume-title":"Prenatal versus postnatal screening for familial retinoblastoma","author":"Soliman","year":"2016","journal-title":"Ophthalmology"},{"key":"key-10.4103\/2211-5056.244532-51","unstructured":"Mallipatna AC, Gallie BL, Ch\u00e9vez-Barrios P, Lumbroso-Le Rouic L, Chantada GL, Doz F, et al. Retinoblastoma. In: Amin MB, Edge SB, Greene FL, Byrd DR, Brookland RK, Washington MK, et al., editors. AJCC Cancer Staging Manual. 8th ed. New York: Springer; 2017. p. 819-31."}],"container-title":["Taiwan Journal of Ophthalmology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:41:32Z","timestamp":1786714892000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/tjo.tjo_37_18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018]]}},"alternative-id":["244532"],"URL":"https:\/\/doi.org\/10.4103\/tjo.tjo_37_18","relation":{},"ISSN":["2211-5056"],"issn-type":[{"value":"2211-5056","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]}}}