{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:47:07Z","timestamp":1793065627198,"version":"4.5.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Extramedullary disease in multiple myeloma is uncommon and associated with a poorer prognosis. Extramedullary disease involving the orbit is even more unusual, with optic nerve involvement being rare. We describe an optic nerve head plasmacytoma in a 45-year-old female in the setting of systemic relapsed, refractory IgA kappa multiple myeloma. The case highlights the importance of keeping extramedullary disease spread in the differential for vision loss in a patient with a history of multiple myeloma. In addition, it describes an unusual location for presentation of extramedullary disease, the optic nerve head, which has rarely been described.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/tjo.tjo_81_20","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T07:12:17Z","timestamp":1612941137000},"page":"97-100","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Optic nerve head plasmacytoma as a manifestation of multiple myeloma"],"prefix":"10.4103","volume":"11","author":[{"given":"Kaitlin P.","family":"Sandor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Micieli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason H.","family":"Peragallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-14-20240830","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1001\/jamaoncol.2018.2128","article-title":"Global burden of multiple myeloma: A systematic analysis for the global burden of disease study 2016","volume":"4","author":"Cowan","year":"2018","journal-title":"JAMA Oncol"},{"key":"R2-14-20240830","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.beha.2005.01.024","article-title":"Neurological aspects of multiple myeloma and related disorders","volume":"18","author":"Dispenzieri","year":"2005","journal-title":"Best Pract Res Clin Haematol"},{"key":"R3-14-20240830","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0039-6257(87)90119-6","article-title":"Multiple myeloma and its ocular manifestations","volume":"31","author":"Knapp","year":"1987","journal-title":"Surv Ophthalmol"},{"key":"R4-14-20240830","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1200\/JCO.2011.34.9290","article-title":"Soft-tissue plasmacytomas in multiple myeloma: Incidence, mechanisms of extramedullary spread, and treatment approach","volume":"29","author":"Blad\u00e9","year":"2011","journal-title":"J Clin Oncol"},{"key":"R5-14-20240830","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/annonc\/mdp329","article-title":"Incidence, presenting features and outcome of extramedullary disease in multiple myeloma: A longitudinal study on 1003 consecutive patients","volume":"21","author":"Varettoni","year":"2010","journal-title":"Ann Oncol"},{"key":"R6-14-20240830","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.survophthal.2009.04.012","article-title":"Characteristics of orbital multiple myeloma: A case report and literature review","volume":"54","author":"Burkat","year":"2009","journal-title":"Surv Ophthalmol"},{"key":"R7-14-20240830","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1001\/archopht.1972.01000020032006","article-title":"Orbital involvement in multiple myeloma. 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