{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:11:35Z","timestamp":1789053095128,"version":"build-2803163510"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Ophthalmic vascular occlusion is an infrequent but devastating complication following cosmetic facial filler injection. We report a case of developing retinal artery occlusion after poly-L-lactic acid (PLLA) injection. A 49-year-old woman with multiple chronic diseases experienced sudden central visual loss and severe ocular pain in the right eye immediately after PLLA injection in the temporal region. Her best-corrected visual acuity in the right eye dropped from 20\/20 to 20\/200. Fundus photography showed marked optic disc edema and localized retinal whitening in the territory of the blocked vessels. Spectral-domain optical coherence tomography revealed localized hyperreflectivity of the inner retina and retinal edema. Fluorescein angiography showed delayed filling of the retinal arteries and absence of retinal perfusion in the affected areas. Despite prompt aggressive management of the condition with ocular massage, topical brimonidine eyedrops, and hyperbaric oxygen therapy, the patient suffered permanent visual loss due to optic atrophy. Among all the subcutaneous filler materials, PLLA has not been a common cause of vascular complications, especially when injected in the temporal region, as this area has not been considered dangerous in the previous literature. Practitioners should be aware of the risk of visual loss, and extra care should be given on those who originally have a higher risk for vascular complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/tjo.tjo_9_21","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T06:22:55Z","timestamp":1618554175000},"page":"317-320","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Retinal artery occlusion following cosmetic injection of poly-L-lactic acid"],"prefix":"10.4103","volume":"11","author":[{"given":"Chao-Wei","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horng-Jiun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-18-20240830","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.ajo.2012.04.019","article-title":"Iatrogenic retinal artery occlusion caused by cosmetic facial filler injections","volume":"154","author":"Park","year":"2012","journal-title":"Am J Ophthalmol"},{"key":"R3-18-20240830","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1001\/jamaophthalmol.2013.8204","article-title":"Iatrogenic occlusion of the ophthalmic artery after cosmetic facial filler injections: A national survey by the Korean Retina Society","volume":"132","author":"Park","year":"2014","journal-title":"JAMA Ophthalmol"},{"key":"R4-18-20240830","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/1090820X10391213","article-title":"Nonsurgical rejuvenation of the aging face with injectable poly-L-lactic acid for restoration of soft tissue volume","volume":"31","author":"Schierle","year":"2011","journal-title":"Aesthet Surg J"},{"key":"R5-18-20240830","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1093\/asj\/sjy012","article-title":"Physiochemical characteristics of poly-L-lactic acid (PLLA)","volume":"38","author":"Fitzgerald","year":"2018","journal-title":"Aesthet Surg J"},{"key":"R6-18-20240830","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1097\/IOP.0b013e3182288e4d","article-title":"Severe visual loss and orbital infarction following periorbital aesthetic poly-(L)-lactic acid (PLLA) injection","volume":"28","author":"Roberts","year":"2012","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"R7-18-20240830","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/WNO.0000000000000459","article-title":"Ipsilateral ophthalmic and cerebral infarctions after cosmetic polylactic acid injection into the forehead","volume":"37","author":"Ragam","year":"2017","journal-title":"J Neuroophthalmol"},{"key":"R8-18-20240830","doi-asserted-by":"crossref","first-page":"e12722","DOI":"10.1111\/dth.12722","article-title":"Prevention and management of iatrogenic blindness associated with aesthetical filler injections","volume":"31","author":"de Lacerda","year":"2018","journal-title":"Dermatol Ther"},{"key":"R9-18-20240830","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1016\/j.ophtha.2009.03.006","article-title":"Retinal artery occlusion: Associated systemic and ophthalmic abnormalities","volume":"116","author":"Hayreh","year":"2009","journal-title":"Ophthalmology"}],"container-title":["Taiwan Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/tjo.tjo_9_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:25:46Z","timestamp":1787844346000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/tjo.tjo_9_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/tjo.tjo_9_21","relation":{},"ISSN":["2211-5056"],"issn-type":[{"value":"2211-5056","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}