{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:43:04Z","timestamp":1791391384478,"version":"4.3.3"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Amebic liver abscess (ALA) occurs in 3%\u20139% of the amebiasis cases, with complications seen in 20%\u201340% of the cases and 2%\u201318% mortality rate. Successful treatment thus requires the accurate identification of these cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims and Objectives:<\/jats:title>\n                    <jats:p>We aimed to assess the seropositivity and profile of ALA patients in western Rajasthan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This retrospective study was conducted at a tertiary care center in western Rajasthan from November 2017 to May 2019. Serological diagnosis of ALA was done by detecting immunoglobulin G (IgG) antibodies in the serum of the patients by ELISA. The derangements in laboratory profile (hematological and biochemical parameters) and ultrasonography findings were assessed from the hospital records. Statistical analysis was performed using Mann\u2013Whitney U-test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among the total cases (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 34), 20 were diagnosed as ALA. Twenty-one (61.8%) were positive for anti-amebic IgG antibodies. Among ALA patients, 14 (70%) were &gt;40 years old and only 6 (30%) patients were of age \u226440 years. Male: female ratio was 5.7:1, and ultrasonography records of 15 ALA patients revealed the presence of hepatomegaly (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 7, 46.7%), pleural effusion (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 3, 20%), lung collapse (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 2, 13.3%), and vascular involvement (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 1, 6.7%). The right lobe of the liver was involved in majority of the patients (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 12, 80%). Total white blood cell count (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), absolute neutrophil count (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001), total serum bilirubin (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.019), and serum alkaline phosphatase (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.018) were significantly elevated in ALA patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Seroprevalence shows that ALA still remains the dominant etiology in liver abscess patients in this region. There are significant derangements in the laboratory profile that require a larger study for corroboration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/tp.tp_38_20","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T05:03:44Z","timestamp":1669266224000},"page":"113-118","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Clinical and laboratory profile of patients with amoebic liver abscess"],"prefix":"10.4103","volume":"12","author":[{"given":"Yashik","family":"Bansal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Maurya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibhor","family":"Tak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopal Krishna","family":"Bohra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhil Dhanesh","family":"Goel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taruna","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya Lakshmi","family":"Nag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8-20240909","doi-asserted-by":"crossref","first-page":"142382","DOI":"10.1155\/2014\/142382","article-title":"Clinical, laboratory, and management profile in patients of liver abscess from northern India","volume":"2014","author":"Ghosh","year":"2014","journal-title":"J Trop Med"},{"key":"R2-8-20240909","doi-asserted-by":"crossref","first-page":"9593865","DOI":"10.1155\/2018\/9593865","article-title":"Hepatic abscess in a returning traveler with Crohn's disease: Differentiating amebic from pyogenic liver abscess","volume":"2018","author":"Gaut","year":"2018","journal-title":"Case Rep Med"},{"key":"R3-8-20240909","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s41182-020-0193-2","article-title":"Entamoeba histolytica and amoebic liver abscess in northern Sri Lanka: A public health problem","volume":"48","author":"Tharmaratnam","year":"2020","journal-title":"Trop Med Health"},{"key":"R4-8-20240909","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/jgh3.12183","article-title":"Evaluation of factors associated with complications in amoebic liver abscess in a predominantly toddy-drinking population: A retrospective study of 198 cases","volume":"3","author":"Jha","year":"2019","journal-title":"JGH Open"},{"key":"R5-8-20240909","first-page":"11","article-title":"Amoebic liver abscess with synchronous colitis: Lessons learnt in recent times","volume":"67","author":"Bhatia","year":"2019","journal-title":"J Assoc Physicians India"},{"key":"R6-8-20240909","doi-asserted-by":"crossref","first-page":"e0214880","DOI":"10.1371\/journal.pone.0214880","article-title":"Prevalence of cases of amebic liver abscess in a tertiary care centre in India: A study on risk factors, associated microflora and strain variation of Entamoeba histolytica","volume":"14","author":"Singh","year":"2019","journal-title":"PLoS One"},{"key":"R7-8-20240909","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13071-016-1950-2","article-title":"Amoebic liver abscess in northern Sri Lanka: First report of immunological and molecular confirmation of aetiology","volume":"10","author":"Kannathasan","year":"2017","journal-title":"Parasit Vectors"},{"key":"R8-8-20240909","doi-asserted-by":"crossref","first-page":"916","DOI":"10.4253\/wjge.v7.i9.916","article-title":"Unusual complication of amebic liver abscess: Hepatogastric fistula","volume":"7","author":"Pawar","year":"2015","journal-title":"World J Gastrointest Endosc"},{"key":"R9-8-20240909","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4103\/JLP.JLP_91_17","article-title":"Decreasing trend of seroprevalence of hepatic amoebiasis in tertiary care hospital of North India: 2010-2015","volume":"10","author":"Agrawal","year":"2018","journal-title":"J Lab Physicians"},{"key":"R10-8-20240909","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/bmb\/ldz032","article-title":"Liver abscess: Diagnostic and management issues found in the low resource setting","volume":"132","author":"Khim","year":"2019","journal-title":"Br Med Bull"},{"key":"R11-8-20240909","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4318\/tjg.2010.0062","article-title":"What is the most accurate method in the diagnosis of amebic dysentery?","volume":"21","author":"Kalkan","year":"2010","journal-title":"Turk J Gastroenterol"},{"key":"R12-8-20240909","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4103\/2229-5070.175116","article-title":"Seroprevalence of Entamoeba histolytica from a tertiary care hospital, South India","volume":"6","author":"Dhanalakshmi","year":"2016","journal-title":"Trop Parasitol"},{"key":"R13-8-20240909","first-page":"53","article-title":"A status survey of common water-borne diseases in desert city Bikaner (NW Rajasthan, India)","volume":"36","author":"Saxena","year":"2004","journal-title":"J Commun Dis"},{"key":"R14-8-20240909","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s10661-010-1427-2","article-title":"Contaminated drinking water and rural health perspectives in Rajasthan, India: An overview of recent case studies","volume":"173","author":"Suthar","year":"2011","journal-title":"Environ Monit Assess"},{"key":"R15-8-20240909","first-page":"799","article-title":"Investigation of the outbreak of typhoid in a village of Thar Desert Rajasthan, India","volume":"131","author":"Anand","year":"2010","journal-title":"Indian J Med Res"},{"key":"R16-8-20240909","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.4103\/jfmpc.jfmpc_144_19","article-title":"Impact assessment of India's Swachh Bharat Mission Clean India Campaign on acute diarrheal disease outbreaks: Yes, there is a positive change","volume":"8","author":"Dandabathula","year":"2019","journal-title":"J Family Med Prim Care"},{"key":"R17-8-20240909","doi-asserted-by":"crossref","first-page":"644","DOI":"10.2169\/internalmedicine.42.644","article-title":"Alcohol consumption, hepatic iron load and the risk of amoebic liver abscess: A case-control study","volume":"42","author":"Makkar","year":"2003","journal-title":"Intern Med"},{"key":"R18-8-20240909","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1365-3156.2004.01246.x","article-title":"Features distinguishing amoebic from pyogenic liver abscess: A review of 577 adult cases","volume":"9","author":"Lodhi","year":"2004","journal-title":"Trop Med Int Health"},{"key":"R20-8-20240909","doi-asserted-by":"crossref","first-page":"6901751","DOI":"10.1155\/2018\/6901751","article-title":"Amoebic liver abscess and indigenous alcoholic beverages in the tropics","volume":"2018","author":"Kumanan","year":"2018","journal-title":"J Trop Med"},{"key":"R21-8-20240909","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12889-018-5036-2","article-title":"Epidemiology and factors associated with amoebic liver abscess in northern Sri Lanka","volume":"18","author":"Kannathasan","year":"2018","journal-title":"BMC Public Health"},{"key":"R22-8-20240909","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/qjmed\/hcy148","article-title":"The special case of left lobe amoebic liver abscess","volume":"112","author":"Jolobe","year":"2019","journal-title":"QJM"},{"key":"R23-8-20240909","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1007\/s00261-020-02409-6","article-title":"Venous thrombosis and segmental hypoperfusion in amebic liver abscess: MDCT demonstration and its implications","volume":"45","author":"Priyadarshi","year":"2020","journal-title":"Abdom Radiol (NY"},{"key":"R24-8-20240909","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1383-5769(03)00025-4","article-title":"Effective human defense against E. histolytica: High amoebicidal activity of lymphocytes and monocytes in amoebic liver abscess patients until 3 months follow-up","volume":"52","author":"Vohra","year":"2003","journal-title":"Parasitol Int"},{"key":"R25-8-20240909","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1093\/qjmed\/hcy105","article-title":"Amoebic liver abscess","volume":"111","author":"Mohidin","year":"2018","journal-title":"QJM"},{"key":"R26-8-20240909","doi-asserted-by":"crossref","first-page":"e1003096","DOI":"10.1371\/journal.ppat.1003096","article-title":"TNF\u03b1-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection","volume":"9","author":"Helk","year":"2013","journal-title":"PLoS Pathog"},{"key":"R27-8-20240909","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/jtm.12007","article-title":"False-negative serologies in amebic liver abscess: Report of two cases","volume":"20","author":"Otto","year":"2013","journal-title":"J Travel Med"}],"container-title":["Tropical Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/tp.TP_38_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:16:44Z","timestamp":1787757404000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/tp.TP_38_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/tp.tp_38_20","relation":{},"ISSN":["2229-5070"],"issn-type":[{"value":"2229-5070","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]}}}