{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:43:35Z","timestamp":1786653815379,"version":"build-2736575974"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Giardiasis is increasingly recognized as a systemic illness beyond its classical intestinal manifestations. This study aimed to characterize systemic manifestations across age groups by evaluating hematological, hepatic, and iron profiles. A retrospective cross-sectional analysis was conducted on 105 giardiasis cases in a tertiary center between 2022 and 2024, stratified by age. All infants exhibited reduction in packed cell volume, mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH); adolescents showed significant MCV reduction (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.018); young adults displayed reduced MCH (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.019). Elevated bilirubin is observed in children (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.025) and adolescents (P = 0.009). Most striking was iron metabolism dysregulation in 100% adults aged 18\u201360 years. The study also showed a male predominance (70.5%), with a seasonal peak during the monsoon period. These findings indicate that giardiasis causes age-specific systemic effects, with iron metabolism disruption in adults emerging as a key treatment focus.\n                  <\/jats:p>","DOI":"10.4103\/tp.tp_47_25","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T19:00:53Z","timestamp":1778007653000},"page":"74-78","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The hidden burden of giardiasis: Characterizing alterations in hematological, hepatic, and iron profile"],"prefix":"10.4103","volume":"16","author":[{"given":"Gargee","family":"Anand","sequence":"first","affiliation":[{"name":"Department of Microbiology, All India Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prathyusha","family":"Kokkayil","sequence":"additional","affiliation":[{"name":"Department of Microbiology, All India Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketan","family":"Priyadarshi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, All India Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaskar","family":"Thakuria","sequence":"additional","affiliation":[{"name":"Department of Microbiology, All India Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"R1-20260506","doi-asserted-by":"crossref","first-page":"i5369","DOI":"10.1136\/bmj.i5369","article-title":"Giardiasis","volume":"355","author":"Minetti","year":"2016","journal-title":"BMJ"},{"key":"R2-20260506","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.4103\/jfmpc.jfmpc_196_19","article-title":"Prevalence of intestinal parasites among rural and 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Ahwaz, Iran","volume":"14","author":"Monajemzadeh","year":"2008","journal-title":"Med Sci Monit"},{"key":"R14-20260506","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1046\/j.1442-200X.2002.01550.x","article-title":"Serological levels of zinc, copper and iron elements among Giardia lamblia infected children in Turkey","volume":"44","author":"Ertan","year":"2002","journal-title":"Pediatr Int"},{"key":"R15-20260506","first-page":"89","article-title":"Hepatic manifestations in giardiasis","volume":"15","author":"Sotto","year":"1985","journal-title":"Acta Gastroenterol Latinoam"}],"container-title":["Tropical 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