{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:43:40Z","timestamp":1786653820408,"version":"build-2736575974"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to characterize the epidemiological patterns of imported severe malaria cases between 2020 and 2023 and investigate the most common serious clinical presentations observed at the time of hospital admission. Understanding these patterns would contribute to improved patient care and treatment protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This single-center, retrospective study analyzed the records of patients treated for severe imported malaria at Moscow\u2019s Infectious Diseases State Hospital No. 2 between 2020 and 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In total, 32 patients met the World Health Organization (WHO) criteria for severe malaria. The study group had a median age of 41 (interquartile range [IQR]: 36\u201352), was predominantly male (89%), and consisted mostly of individuals of Russian descent (91.2%). Nearly all acquired their infection in sub-Saharan African countries. No patient used malaria chemoprophylaxis before, during, or after visit to these countries. Patients typically sought medical attention a median of 5 days after their symptoms first appeared (IQR: 4\u20136).\n                      <jats:italic toggle=\"yes\">Plasmodium falciparum<\/jats:italic>\n                      was the sole causative agent in every severe malaria case. A significant proportion of patients presented with high parasitemia and altered consciousness at the time of hospital admission (99% and 98%, respectively). The other prevalent indicators of severe malaria, as per the WHO guidelines, observed at admission were profound physical weakness (78.1%) and jaundice (52%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The findings emphasize the crucial role that antimalarial medication and prompt medical attention play in both preventing malaria and mitigating its severity. Prompt diagnosis and treatment of\n                      <jats:italic toggle=\"yes\">Plasmodium falciparum<\/jats:italic>\n                      is crucial, as delays in identification can lead to more severe illness. Our investigation also highlights the necessity of improving pretravel consulting procedures.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/tp.tp_65_25","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T19:00:44Z","timestamp":1778007644000},"page":"40-46","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and epidemiological profile of severe imported Plasmodium falciparum malaria in travelers at hospital admission: A retrospective single-center study in Moscow, Russia"],"prefix":"10.4103","volume":"16","author":[{"given":"Karl","family":"Emerole","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, RUDN University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatoly","family":"Tokmalaev","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, RUDN University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vellynance","family":"Mvuania","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, RUDN University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"R1-20260506","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1186\/s12936-021-03984-9","article-title":"High prevalence of malaria in a non-endemic setting among febrile episodes in travellers and migrants coming from endemic areas: A retrospective analysis of a 2013-2018 cohort","volume":"20","author":"Garcia-Ruiz de Morales","year":"2021","journal-title":"Malar J"},{"key":"R3-20260506","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S1473-3099(16)30326-7","article-title":"The geography of imported malaria to non-endemic countries: A meta-analysis of nationally reported statistics","volume":"17","author":"Tatem","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"R4-20260506","doi-asserted-by":"crossref","first-page":"456","DOI":"10.7326\/0003-4819-158-6-201303190-00005","article-title":"GeoSentinel surveillance of illness in returned travelers, 2007\u20132011","volume":"158","author":"Leder","year":"2013","journal-title":"Ann Intern Med"},{"key":"R6-20260506","first-page":"77","article-title":"Epidemiological and clinical aspects of diagnosis, treatment and prophylaxis of imported malaria cases in Russian federation","volume":"92","author":"Tokmalaev","year":"2020","journal-title":"Ter Arkh"},{"key":"R8-20260506","doi-asserted-by":"crossref","first-page":"e1003359","DOI":"10.1371\/journal.pmed.1003359","article-title":"The impact of delayed treatment of uncomplicated P. falciparum malaria on progression to severe malaria: A systematic review and a pooled multicentre individual-patient meta-analysis","volume":"17","author":"Mousa","year":"2020","journal-title":"PLoS Med"},{"key":"R9-20260506","first-page":"230","article-title":"Management of severe Plasmodium falciparum malaria in adults: A review of national and regional guidelines and their adherence to World Health Organization guidelines","volume":"28","author":"Tokmalaev","year":"2023","journal-title":"Epidemiol Infect Dis"},{"key":"R10-20260506","first-page":"4","article-title":"Problems of clinical diagnosis and treatment of P. falciparum malaria in Russian federation","volume":"90","author":"Sergiev","year":"2018","journal-title":"Ter Arkh"},{"key":"R11-20260506","first-page":"97","article-title":"Clinical suspicion to imported malaria: transfusion cases and deaths in Russia","volume":"7","author":"Baranova","year":"2018","journal-title":"Infect Dis News Opin Train"},{"key":"R13-20260506","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s12936-022-04282-8","article-title":"Epidemiology and clinical features of imported malaria: A 14-year retrospective single-centre descriptive study in Prague, Czech Republic","volume":"21","author":"Troj\u00e1nek","year":"2022","journal-title":"Malar J"},{"key":"R14-20260506","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3201\/eid1705.101527","article-title":"Severe imported Plasmodium falciparum malaria, France, 1996\u20132003","volume":"17","author":"Seringe","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"R15-20260506","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1475-2875-11-96","article-title":"Severe imported malaria in an intensive care unit: A review of 59 cases","volume":"11","author":"Santos","year":"2012","journal-title":"Malar J"},{"key":"R16-20260506","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1471-2334-13-118","article-title":"Severe imported falciparum malaria among adults requiring intensive care: A retrospective study at the hospital for tropical diseases, London","volume":"13","author":"Marks","year":"2013","journal-title":"BMC Infect Dis"},{"key":"R17-20260506","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3201\/eid1203.050736","article-title":"Chemoprophylaxis and malaria death rates","volume":"12","author":"Krause","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"R18-20260506","doi-asserted-by":"crossref","first-page":"102408","DOI":"10.1016\/j.tmaid.2022.102408","article-title":"Prevalence, anti-malarial chemoprophylaxis and causes of deaths for severe imported malaria: A systematic review and meta-analysis","volume":"49","author":"Mahittikorn","year":"2022","journal-title":"Travel Med Infect Dis"},{"key":"R19-20260506","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.cmi.2024.06.021","article-title":"How to manage adult patients with malaria in the non-endemic setting","volume":"30","author":"Antinori","year":"2024","journal-title":"Clin Microbiol Infect"},{"key":"R21-20260506","doi-asserted-by":"crossref","first-page":"1628270","DOI":"10.1155\/2020\/1628270","article-title":"Optimizing the intensive care treatment of severe and complicated Plasmodium falciparum malaria in nonimmune patients","volume":"2020","author":"Chentsov","year":"2020","journal-title":"J Trop Med"},{"key":"R22-20260506","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1093\/cid\/cix437","article-title":"Obesity and diabetes as risk factors for severe Plasmodium falciparum malaria: Results from a Swedish nationwide study","volume":"65","author":"Wyss","year":"2017","journal-title":"Clin Infect Dis"},{"key":"R23-20260506","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.4269\/ajtmh.23-0178","article-title":"Opportunities for improving outcomes in severe malaria: The role of blood glucose monitoring","volume":"108","author":"Torres-Fernandez","year":"2023","journal-title":"Am J Trop Med Hyg"},{"key":"R24-20260506","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4172\/2470-6965.1000147","article-title":"Management Malaria with Jaundice","volume":"5","author":"Utama","year":"2016","journal-title":"Malaria Contr Elimination"},{"key":"R25-20260506","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1093\/infdis\/jiz292","article-title":"Severity of Plasmodium falciparum and non-falciparum malaria in travelers and migrants: A nationwide observational study over 2 decades in Sweden","volume":"220","author":"W\u00e5ngdahl","year":"2019","journal-title":"J Infect Dis"},{"key":"R26-20260506","doi-asserted-by":"crossref","first-page":"102740","DOI":"10.1016\/j.tmaid.2024.102740","article-title":"Not all severe malaria cases are severe: Is it time to redefine severity criteria for malaria in non-endemic regions?","volume":"60","author":"Balerdi-Sarasola","year":"2024","journal-title":"Travel Med Infect Dis"},{"key":"R27-20260506","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.medmal.2018.08.003","article-title":"Management of severe imported malaria in adults","volume":"50","author":"Bruneel","year":"2020","journal-title":"Med Mal Infect"},{"key":"R28-20260506","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/1475-2875-11-328","article-title":"Management of imported malaria in Europe","volume":"11","author":"Askling","year":"2012","journal-title":"Malar J"},{"key":"R29-20260506","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.eimc.2013.12.014","article-title":"Diagnosis and treatment of imported malaria in Spain: Recommendations from the malaria working group of the Spanish society of tropical medicine and international health (SEMTSI)]","volume":"33","author":"Mu\u00f1oz","year":"2015","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"R30-20260506","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jinf.2016.02.001","article-title":"UK malaria treatment guidelines 2016","volume":"72","author":"Lalloo","year":"2016","journal-title":"J Infect"},{"key":"R33-20260506","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s12936-022-04301-8","article-title":"Severe malaria","volume":"21","author":"White","year":"2022","journal-title":"Malar J"},{"key":"R34-20260506","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3201\/eid1705.101229","article-title":"Intravenous artesunate for severe malaria in travelers, Europe","volume":"17","author":"Zoller","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"R35-20260506","first-page":"CD005967","article-title":"Artesunate versus quinine for treating severe malaria","volume":"2012","author":"Sinclair","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"R36-20260506","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12936-018-2174-z","article-title":"Manual exchange transfusion for severe imported falciparum malaria: A retrospective study","volume":"17","author":"Lin","year":"2018","journal-title":"Malar J"},{"key":"R37-20260506","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12936-018-2195-7","article-title":"Adjunctive therapy for severe malaria: A review and critical appraisal","volume":"17","author":"Varo","year":"2018","journal-title":"Malar J"},{"key":"R38-20260506","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1586\/eri.10.90","article-title":"Adjunctive therapy for cerebral malaria and other severe forms of Plasmodium falciparum malaria","volume":"8","author":"John","year":"2010","journal-title":"Expert Rev Anti Infect Ther"},{"key":"R39-20260506","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1086\/519287","article-title":"Levamisole inhibits sequestration of infected red blood cells in patients with falciparum malaria","volume":"196","author":"Dondorp","year":"2007","journal-title":"J Infect Dis"}],"container-title":["Tropical Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/tp.tp_65_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:42:50Z","timestamp":1786650170000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/tp.tp_65_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/tp.tp_65_25","relation":{},"ISSN":["2229-5070","2229-7758"],"issn-type":[{"value":"2229-5070","type":"print"},{"value":"2229-7758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-08-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}