{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:35:26Z","timestamp":1787758526130,"version":"build-2784847793"},"reference-count":84,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Entamoeba histolytica<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">E. histolytica<\/jats:italic>\n                      ) is an enteric microaerophilic protozoan parasite responsible for millions of cases worldwide. Majority of the infections due to\n                      <jats:italic toggle=\"yes\">E. histolytica<\/jats:italic>\n                      remain asymptomatic; however, it can cause an array of symptoms ranging from devastating dysentery, colitis, and abscesses in different vital organs. The interactions between the\n                      <jats:italic toggle=\"yes\">E. histolytica<\/jats:italic>\n                      and its host are a multifaceted chain of events rather than merely destruction and invasion. There are manifold decisive steps for the establishment of infections by\n                      <jats:italic toggle=\"yes\">E. histolytica<\/jats:italic>\n                      which includes degradation of mucosal layer, adherence to the host epithelium, invasion into the host tissues, and dissemination to vital organs. It is widely hypothesized that, for establishment of infections, the interactions at the intestinal mucosa decides the fate of the disease. The delicate communications between the parasite, the host factors, and the associated bacterial microflora play a significant role in the pathogenesis of\n                      <jats:italic toggle=\"yes\">E. histolytica<\/jats:italic>\n                      . In this review, we summarize the interactions between the\n                      <jats:italic toggle=\"yes\">E. histolytica<\/jats:italic>\n                      and it's host at the genetic and immunological interphases emphasizing the crucial role of microbiota in these interactions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/tp.tp_81_21","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T05:03:44Z","timestamp":1669266224000},"page":"69-77","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Host-parasite interactions in infections due to Entamoeba histolytica"],"prefix":"10.4103","volume":"12","author":[{"given":"Aradhana","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuhina","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-2-20240909","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4269\/ajtmh.2007.76.549","article-title":"Prevalence of enteric protozoa in human immunodeficiency virus (HIV)-positive and HIV-negative men who have sex with men from Sydney, Australia","volume":"76","author":"Stark","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"R3-2-20240909","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.3201\/eid1407.080017","article-title":"Invasive amebiasis in men who have sex with men, Australia","volume":"14","author":"Stark","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"R4-2-20240909","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s00436-005-0024-8","article-title":"Prevalence and genetic diversity of Entamoeba histolytica in an institution for the mentally retarded in the Philippines","volume":"98","author":"Rivera","year":"2006","journal-title":"Parasitol Res"},{"key":"R5-2-20240909","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1179\/136485910X12743554760388","article-title":"Mass infection with Entamoeba histolytica in a Japanese institution for individuals with mental retardation: Epidemiology and control measures","volume":"104","author":"Nishise","year":"2010","journal-title":"Ann Trop Med Parasitol"},{"key":"R6-2-20240909","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.3390\/ijerph7031105","article-title":"Human amebiasis: Breaking the paradigm?","volume":"7","author":"Xim\u00e9nez","year":"2010","journal-title":"Int J Environ Res Public Health"},{"key":"R7-2-20240909","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1128\/CMR.13.2.318","article-title":"Pathogenesis of intestinal amebiasis: From molecules to disease","volume":"13","author":"Espinosa-Cantellano","year":"2000","journal-title":"Clin Microbiol Rev"},{"key":"R8-2-20240909","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev.micro.56.012302.160959","article-title":"The bittersweet interface of parasite and host: Lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica","volume":"56","author":"Petri","year":"2002","journal-title":"Annu Rev Microbiol"},{"key":"R9-2-20240909","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3389\/fimmu.2016.00175","article-title":"Immune response of amebiasis and immune evasion by Entamoeba histolytica","volume":"7","author":"Nakada-Tsukui","year":"2016","journal-title":"Front Immunol"},{"key":"R10-2-20240909","doi-asserted-by":"crossref","first-page":"15828","DOI":"10.1074\/jbc.274.22.15828","article-title":"Studies on the \u201cinsoluble\u201d glycoprotein complex from human colon. 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