{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:18:34Z","timestamp":1787847514185,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10]]},"abstract":"\n Introduction:<\/jats:title>\n The association between inflammation and malignancies is being recognized. In this study, we assessed the use of preoperative neutrophil\u2013lymphocyte ratio (NLR) and lymphocyte\u2013monocyte ratio (LMR) in predicting cancer-specific survival (CSS) and inguinal node involvement in patients with carcinoma penis.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Sixty-nine patients operated for squamous cell carcinoma penis with inguinal node dissection between 2012 and 2020 were identified. We recorded the type of surgery (partial\/total penectomy), T stage, grade, lymphovascular invasion (LVI), perineural invasion (PNI), pathological status of inguinal nodes and nodal stage (pN1\u20133), extranodal extension (ENE), and CSS. The hemogram performed within 2 weeks of surgery was used for calculating NLR and LMR.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Partial penectomy was the most common surgery (65.22%) and pT2 was the most common stage (53.62%). Grade 2 was seen in 66.67%, LVI in 34.78%, PNI in 37.68%, 52.17% had inguinal node involvement with pN3 being the most common (36.23%), and 36.23% had ENE. Kaplan\u2013Meier analysis revealed that NLR of >3 and the LMR \u22643 indicated an inferior CSS (\n P<\/jats:italic>\n = 0.05 and 0.04, respectively). T stage, inguinal node involvement, LVI, pN stage, and ENE were also associated with inferior CSS (\n P<\/jats:italic>\n < 0.05). On multivariate analysis, T stage was significantly associated with CSS (\n P<\/jats:italic>\n = 0.02). The NLR >3 and LMR \u22643 were also significantly associated with the presence of pathological inguinal node involvement (\n P<\/jats:italic>\n = 0.001 and 0.026).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n NLR and LMR may help in predicting CSS and inguinal node involvement in patients of carcinoma penis.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ua.ua_112_20","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T08:11:58Z","timestamp":1624349518000},"page":"391-396","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["The use of preoperative neutrophil\u2013lymphocyte ratio and lymphocyte\u2013monocyte ratio in predicting survival and groin node involvement of patients with squamous cell carcinoma of penis"],"prefix":"10.4103","volume":"13","author":[{"given":"Tarun","family":"Jindal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravin","family":"Pawar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjit","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prateek","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Meena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankush","family":"Sarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Dhanalakshmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20240828","first-page":"e117","article-title":"Incidence of penile cancer worldwide: Systematic review and meta-analysis","volume":"41","author":"Montes Cardona","year":"2017","journal-title":"Rev Panam Salud Publica"},{"key":"R2-12-20240828","doi-asserted-by":"crossref","first-page":"309","DOI":"10.4103\/0019-509X.197729","article-title":"Prognostic factors and 5-year survival of patients with carcinoma penis: Tertiary health center study","volume":"53","author":"Shah","year":"2016","journal-title":"Indian J Cancer"},{"key":"R3-12-20240828","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.2147\/CMAR.S206579","article-title":"Predictors of inguinal lymph node metastasis in penile cancer patients: A meta-analysis of retrospective studies","volume":"11","author":"Hu","year":"2019","journal-title":"Cancer Manag Res"},{"key":"R4-12-20240828","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/sj.bjc.6606087","article-title":"An inflammation-based prognostic score (mGPS) predicts cancer survival independent of tumour site: A Glasgow Inflammation Outcome Study","volume":"104","author":"Proctor","year":"2011","journal-title":"Br J Cancer"},{"key":"R5-12-20240828","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.euf.2018.06.008","article-title":"Prognostic value of neutrophil-to-lymphocyte ratio in penile squamous cell carcinoma patients undergoing inguinal lymph node dissection","volume":"5","author":"Azizi","year":"2019","journal-title":"Eur Urol Focus"},{"key":"R6-12-20240828","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1186\/s12885-016-2443-6","article-title":"Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer","volume":"16","author":"Kasuga","year":"2016","journal-title":"BMC Cancer"},{"key":"R7-12-20240828","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.clgc.2014.03.009","article-title":"Concurrent chemoradiotherapy for men with locally advanced penile squamous cell carcinoma","volume":"12","author":"Pond","year":"2014","journal-title":"Clin Genitourin Cancer"},{"key":"R8-12-20240828","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/iju.14137","article-title":"Prognostic significance of common preoperative laboratory variables in penile squamous cell carcinoma","volume":"27","author":"Li","year":"2020","journal-title":"Int J Urol"},{"key":"R9-12-20240828","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.aju.2017.03.001","article-title":"Management of penile cancer in a Singapore tertiary hospital","volume":"15","author":"Tan","year":"2017","journal-title":"Arab J Urol"},{"key":"R10-12-20240828","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/sj.bjc.6605855","article-title":"The relationship between the presence and site of cancer, an inflammation-based prognostic score and biochemical parameters. Initial results of the Glasgow Inflammation Outcome Study","volume":"103","author":"Proctor","year":"2010","journal-title":"Br J Cancer"},{"key":"R11-12-20240828","doi-asserted-by":"crossref","first-page":"305","DOI":"10.5858\/arpa.2019-0544-RA","article-title":"Updates in staging and reporting of genitourinary malignancies","volume":"144","author":"Cornejo","year":"2020","journal-title":"Arch Pathol Lab Med"}],"container-title":["Urology Annals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/UA.UA_112_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:20:40Z","timestamp":1787844040000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/UA.UA_112_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/ua.ua_112_20","relation":{},"ISSN":["0974-7796"],"issn-type":[{"value":"0974-7796","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]}}}