{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:01:22Z","timestamp":1791666082280,"version":"4.3.4"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We conduct a secondary analysis on the demographics, tumor characteristics, survival, and risk factors for mortality among patients with prostatic ductal adenocarcinoma (PDA) in the Kingdom of Saudi Arabia (KSA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This is a registry-based retrospective study that included all patients diagnosed with prostate cancer in the KSA. The data were collected from the Saudi Cancer Registry, which collects tumor data from all private, military, and health ministry hospitals in Saudi Arabia through five regional offices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 3607 prostate cancer patients detected during the specified period, 209 (5.8%) had ductal adenocarcinoma. The median interquartile range age of patients was 72.0 years (64.0\u201378.0). Adenocarcinoma lesions were malignant among all the patients. Grade III tumors were most frequently apparent lesions (61.2%), followed by Grade II tumors (26.3%), Grade I tumors (7.2%), and Grade VI tumors (5.3%). A total of 33 patients died, representing 15.8% of the whole sample. The 1-year survival rate was 78.1%. More than a third of patients who were residing in the Western region deceased (38.0%), whereas no deaths were reported in other regions with a statistically significant difference based on regions (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>To the best of our knowledge, this is the first registry-based study to investigate PDA in the KSA; these efforts were done to further understand this deadly condition and to further enhance patient care in the KSA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ua.ua_46_23","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T06:21:38Z","timestamp":1689661298000},"page":"320-324","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["An unusually high prevalence of isolated prostatic ductal adenocarcinoma among Saudi patients: A registry-based study"],"prefix":"10.4103","volume":"15","author":[{"given":"Ahmed","family":"Alasker","sequence":"first","affiliation":[{"name":"Department of Urology, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"},{"name":"King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"},{"name":"Department of Urology, King Abdulaziz Medical City, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Alghafees","sequence":"additional","affiliation":[{"name":"Department of Urology, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman N.","family":"Chaudhri","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah A.","family":"Al Qurashi","sequence":"additional","affiliation":[{"name":"King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"},{"name":"Department of Medicine, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleha","family":"Abdul Rab","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belal N.","family":"Sabbah","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyad","family":"Musalli","sequence":"additional","affiliation":[{"name":"Department of Urology, King Abdulaziz Medical City, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Alyami","sequence":"additional","affiliation":[{"name":"Department of Urology, King Abdulaziz Medical City, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"R2-20240828","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1097\/PAI.0000000000000508","article-title":"Prostate ductal adenocarcinoma","volume":"26","author":"Amin","year":"2018","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"R3-20240828","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/apm.12504","article-title":"Immunohistochemistry of ductal adenocarcinoma of the prostate and adenocarcinomas of non-prostatic origin:A comparative study","volume":"124","author":"Seipel","year":"2016","journal-title":"APMIS"},{"key":"R4-20240828","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.anndiagpath.2019.02.007","article-title":"Prostatic ductal adenocarcinoma with cribriform architecture has worse prognostic features than non-cribriform-type","volume":"39","author":"Au","year":"2019","journal-title":"Ann Diagn Pathol"},{"key":"R5-20240828","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/bco2.60","article-title":"Ductal adenocarcinoma of the prostate:A systematic review and meta-analysis of incidence, presentation, prognosis, and management","volume":"2","author":"Ranasinha","year":"2021","journal-title":"BJUI Compass"},{"key":"R6-20240828","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5144\/0256-4947.2022.17","article-title":"Bladder cancer in Saudi Arabia:A registry-based nationwide descriptive epidemiological and survival analysis","volume":"42","author":"Alghafees","year":"2022","journal-title":"Ann Saudi Med"}],"container-title":["Urology 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