{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:25:26Z","timestamp":1787772326064,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>The embryonal male sexual differentiation is driven by testosterone, and Anti-M\u00fcllerian hormone (AMH). AMH is responsible for regression of M\u00fcllerian ducts in a genetically male fetus. Mutations inactivating AMH or its receptors are responsible for persistent M\u00fcllerian duct syndrome (PMDS) in virilized 46, XY males. PMDS is a rare genetic disorder affecting males, with less than 300 cases described in literature. The syndrome is usually recognized early in life with patients present with bilateral undescended testicles, and often decreased testosterone production by Leydig cells later in life. The role of testosterone in the development and progression of prostate cancer is well established, and men with low circulating free testosterone are expected to have a lower risk of developing prostate cancer. Indeed, 2 cases of prostate cancer in patients with PMDS have previously been described. Herein, we are reporting the third of prostate cancer in patient with PMDS.<\/jats:p>","DOI":"10.4103\/ua.ua_74_21","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T08:53:52Z","timestamp":1716454432000},"page":"398-402","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Prostatic adenocarcinoma in a patient with persistent M\u00fcllerian duct syndrome"],"prefix":"10.4103","volume":"14","author":[{"given":"Muhammad","family":"Umair","sequence":"first","affiliation":[{"name":"Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahsan U.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Radiology, West Virginia University, Morgantown, WV 26506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Arruda","sequence":"additional","affiliation":[{"name":"Department of Urology, West Virginia University, Morgantown, WV 26506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhairya A.","family":"Lakhani","sequence":"additional","affiliation":[{"name":"Department of Radiology, West Virginia University, Morgantown, WV 26506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayodele","family":"Adelanwa","sequence":"additional","affiliation":[{"name":"Department of Pathology, West Virginia University, Morgantown, WV 26506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousaf B.","family":"Hadi","sequence":"additional","affiliation":[{"name":"Department of Medicine, West Virginia University, Morgantown, WV 26506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Markovich","sequence":"additional","affiliation":[{"name":"Department of Radiology, West Virginia University, 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