{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:08:40Z","timestamp":1793142520575,"version":"4.5.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim is to evaluate the benefits of percutaneous nephrostomy (PCN) for urinary drainage in patients with malignancy-associated urinary obstruction (MUO). This study examines the impact of PCN on immediate renal recovery, procedural morbidity, short-term outcomes, and patient survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 477 patients with ureteric obstruction underwent PCN placement, of whom one-third had MUO. Demographic and clinical parameters were reviewed to assess renal outcomes, complication rates, hospital stay, and overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Nearly two-thirds of the patients with MUO had a primary urological malignancy (bladder cancer 30% and prostate cancer 25%). The mean hospital stay was &lt;7 weeks, with patients with gynecological malignancies experiencing the shortest admissions. During the study period, 59 (37%) patients died. The overall median survival was 107 weeks, with the shortest survival observed in patients with primary colorectal cancer (median 34 weeks). Patients with primary bladder and prostate malignancies demonstrated higher median survival compared to other malignancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>MUO often represents advanced disease in colorectal and gynecological cancers. PCN can be beneficial for selected patients who are candidates for further oncological treatment. However, it should be considered only after careful discussion regarding the potential need for long-term nephrostomy, procedural morbidity, and quality-of-life impact. Although PCN achieved high rates of renal function recovery and had low complication rates (12%\u201317%), the underlying malignancy and associated social factors contributed to prolonged hospital stays, sometimes accounting for up to one-third of a patient\u2019s remaining life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ua.ua_74_25","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:02:11Z","timestamp":1760698931000},"page":"239-244","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Outcome analysis of percutaneous nephrostomy insertion to relieve urinary obstruction in advanced malignancy"],"prefix":"10.4103","volume":"17","author":[{"given":"Kalpesh","family":"Parmar","sequence":"first","affiliation":[{"name":"Department of Urology, Freeman Hospital, Newcastle, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heain Zaw","family":"Htun","sequence":"additional","affiliation":[{"name":"Bristol Urological Institute, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"John","sequence":"additional","affiliation":[{"name":"Southmead Hospital, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanos","family":"Bolomytis","sequence":"additional","affiliation":[{"name":"Bristol Urological Institute, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kesavapilla","family":"Subramonian","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavan Prasad","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Urology, Freeman Hospital, Newcastle, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaskar","family":"Somani","sequence":"additional","affiliation":[{"name":"University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Philip","sequence":"additional","affiliation":[{"name":"Bristol Urological Institute, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"R1-20251017","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1002\/(SICI)1097-0142(19990215)85:4<998::AID-CNCR30>3.0.CO;2-F","article-title":"Outcome of palliative urinary diversion in the treatment of advanced malignancies","volume":"85","author":"Shekarriz","year":"1999","journal-title":"Cancer"},{"key":"R2-20251017","first-page":"284","article-title":"Urologic emergencies in the cancer patient","volume":"27","author":"Russo","year":"2000","journal-title":"Semin Oncol"},{"key":"R3-20251017","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/BF02305670","article-title":"Ureteral decompression in advanced nonurologic malignancies","volume":"3","author":"Donat","year":"1996","journal-title":"Ann Surg Oncol"},{"key":"R4-20251017","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.juro.2008.04.011","article-title":"Prognostic model for predicting survival after palliative urinary diversion for ureteral obstruction: Analysis of 140 cases","volume":"180","author":"Ishioka","year":"2008","journal-title":"J Urol"},{"key":"R5-20251017","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/BF00595827","article-title":"Percutaneous nephrostomy in the management of acute and chronic pelveoureteral obstruction. Genitourinary radiology","volume":"2","author":"Lukes","year":"1992","journal-title":"Eur Radiol"},{"key":"R6-20251017","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1051-0443(94)71470-6","article-title":"Emergency percutaneous nephrostomy: Results and complications","volume":"5","author":"Lee","year":"1994","journal-title":"J Vasc Interv Radiol"},{"key":"R7-20251017","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.crad.2003.10.021","article-title":"Percutaneous nephrostomy insertion: Outcome data from a prospective multi-operator study at a UK training centre","volume":"59","author":"Wah","year":"2004","journal-title":"Clin Radiol"},{"key":"R8-20251017","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1148\/radiol.2331031342","article-title":"Percutaneous nephrostomy of nondilated renal collecting systems with fluoroscopic guidance: Technique and results","volume":"233","author":"Patel","year":"2004","journal-title":"Radiology"},{"key":"R9-20251017","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/j.1464-410X.2009.08492.x","article-title":"Prognostic factors in malignant ureteric obstruction","volume":"104","author":"Lienert","year":"2009","journal-title":"BJU Int"},{"key":"R10-20251017","first-page":"15","article-title":"Palliative diversion for metastatic ureteral obstruction","volume":"8","author":"Abraham","year":"1998","journal-title":"Philipp J Urol"},{"key":"R11-20251017","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.juro.2007.03.026","article-title":"Malignant ureteral obstruction: Outcomes after intervention. Have things changed?","volume":"178","author":"Wong","year":"2007","journal-title":"J Urol"},{"key":"R12-20251017","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1089\/end.2000.14.401","article-title":"Role of percutaneous urinary diversion in malignant and benign obstructive uropathy","volume":"14","author":"Pappas","year":"2000","journal-title":"J Endourol"},{"key":"R13-20251017","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1089\/end.1999.13.521","article-title":"Management of ureteral obstruction secondary to pelvic malignancies","volume":"13","author":"Feng","year":"1999","journal-title":"J Endourol"},{"key":"R14-20251017","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3390\/gidisord2040041","article-title":"Ureteral stent and percutaneous nephrostomy in managing malignant ureteric obstruction of gastrointestinal origin: A 10 years\u2019 experience","volume":"2","author":"De Lorenzis","year":"2020","journal-title":"Gastrointest Disord"},{"key":"R15-20251017","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0009-9260(05)81210-3","article-title":"The role of percutaneous nephrostomy in malignant urinary tract obstruction","volume":"47","author":"Watkinson","year":"1993","journal-title":"Clin Radiol"},{"key":"R16-20251017","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1464-410X.1995.tb07779.x","article-title":"Urinary tract obstruction and nephrostomy drainage in pelvic malignant disease","volume":"76","author":"Lau","year":"1995","journal-title":"Br J Urol"},{"key":"R17-20251017","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1308\/1478708051432","article-title":"The role of percutaneous nephrostomy in malignant ureteric obstruction","volume":"87","author":"Wilson","year":"2005","journal-title":"Ann R Coll Surg Engl"},{"key":"R18-20251017","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1464-410X.1980.tb08909.x","article-title":"Nephrostomy in cancer patients: To do or not to do?","volume":"52","author":"Fallon","year":"1980","journal-title":"Br J Urol"},{"key":"R19-20251017","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/CU9.0000000000000183","article-title":"The challenging management of malignant ureteral obstruction: Analysis of a series of 188 cases","volume":"18","author":"Artiles","year":"2024","journal-title":"Curr Urol"}],"container-title":["Urology Annals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ua.ua_74_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:12:46Z","timestamp":1787771566000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ua.ua_74_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ua.ua_74_25","relation":{},"ISSN":["0974-7796","0974-7834"],"issn-type":[{"value":"0974-7796","type":"print"},{"value":"0974-7834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-05-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-28","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}