{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T20:09:38Z","timestamp":1747858178578,"version":"3.30.1"},"reference-count":20,"publisher":"Medknow","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n            <jats:title>Context:<\/jats:title>\n            <jats:p>The use of the CINtec\u00ae PLUS Cytology Kit as a complementary method of diagnosis is intended to contribute to a risk assessment of CIN II+ cervical lesions development, thus avoiding unnecessary colposcopy in negative cases. This method has proved to be effective in the follow-up of cervical lesions, although there is need for consistency in the approach of equivocal or negative cytological results, with persistent positive High-Risk Human Papillomavirus (HR-HPV) test.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Aims:<\/jats:title>\n            <jats:p>The present study intends to retrospectively evaluate the capacity of the CINtec\u00ae to add information to the clinical practice within the screening and follow-up of cervical lesions. Additionally, this study intends to define criteria for CINtec\u00ae referral in order to maximize its utilization in the Portuguese context.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and Methods:<\/jats:title>\n            <jats:p>For this purpose, 225 cases with CINtec\u00ae PLUS Cytology Kit and histology results were used, and data were analysed and compared according to the cytology and HR-HPV molecular test results.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>The data of this study show that CINtec\u00ae PLUS Cytology Kit is a valid test for the diagnosis of persistent HPV lesions (<jats:italic toggle=\"yes\">p<\/jats:italic> = 0.0005), with excellent sensitivity and reliable values of specificity. Relevant patient groups to apply the kit are in agreement with the manufacturer recommendations: women with ASC-US\/LSIL result and NILM cytology with HPV-positive test, essentially over 30 years old.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Although clinical data and previous cytological information must help guiding, authors considered that CINtec\u00ae is a really valid test for the prognosis of persistent HPV infections in the female population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.4103\/joc.joc_173_20","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T10:48:14Z","timestamp":1620643694000},"page":"94-100","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Validation of CINtec\u00ae PLUS Cytology Kit in the Diagnosis of Persistent HPV Infections - Cohort Study in the Portuguese 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