{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:15:19Z","timestamp":1776788119770,"version":"3.51.2"},"reference-count":90,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T00:00:00Z","timestamp":1733529600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>JOURNAL\/nrgr\/04.03\/01300535-202604000-00041\/figure1\/v\/2026-04-21T135625Z\/r\/image-tiff<\/jats:p>\n                  <jats:p>\n                    Contrary to the adult central nervous system, the peripheral nervous system has an intrinsic ability to regenerate that relies on the expression of regeneration-associated genes, such as some kinesin family members. Kinesins contribute to nerve regeneration through the transport of specific cargo, such as proteins and membrane components, from the cell body towards the axon periphery. We show here that KIF4A, associated with neurodevelopmental disorders and previously believed to be only expressed during development, is also expressed in the adult vertebrate nervous system and up-regulated in injured peripheral nervous system cells. KIF4A is detected both in the cell bodies and regrowing axons of injured neurons, consistent with its function as an axonal transporter of cargoes such as \u03b21-integrin and L1CAM. Our study further demonstrates that KIF4A levels are greatly increased in Schwann cells from injured distal nerve stumps, particularly at a time when they are reprogrammed into an essential proliferative repair phenotype. Moreover,\n                    <jats:italic toggle=\"yes\">Kif4a<\/jats:italic>\n                    mRNA levels were approximately\n                    <jats:bold>~<\/jats:bold>\n                    6-fold higher in proliferative cultured Schwann cells compared with non-proliferative ones. A hypothesized function for\n                    <jats:italic toggle=\"yes\">Kif4a<\/jats:italic>\n                    in Schwann cell proliferation was further confirmed by\n                    <jats:italic toggle=\"yes\">Kif4a<\/jats:italic>\n                    knockdown, as this significantly reduced Schwann cell proliferation\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    . Our findings show that KIF4A is expressed in adult vertebrate nervous systems and is up-regulated following peripheral injury. The timing of KIF4A up-regulation, its location during regeneration, and its proliferative role, all suggest a dual role for this protein in neuroregeneration that is worth exploring in the future.\n                  <\/jats:p>","DOI":"10.4103\/nrr.nrr-d-24-00232","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T11:02:07Z","timestamp":1734001327000},"page":"1607-1620","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Injury-induced KIF4A neural expression and its role in Schwann cell proliferation suggest a dual function for this kinesin in neural regeneration"],"prefix":"10.4103","volume":"21","author":[{"given":"Patr\u00edcia D.","family":"Correia","sequence":"first","affiliation":[{"name":"Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal"},{"name":"Molecular Neurobiology Laboratory, Department of Neurology, University-Hospital D\u00fcsseldorf, Heinrich-Heine-University, D\u00fcsseldorf, Germany"},{"name":"Department of Histology & Tissue Engineering Group, University of Granada, Granada, Spain"}]},{"given":"B\u00e1rbara M.","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal"},{"name":"Department of Histology & Tissue Engineering Group, University of Granada, Granada, Spain"}]},{"given":"Jes\u00fas","family":"Chato-Astrain","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal"},{"name":"Department of Histology & Tissue Engineering Group, University of Granada, Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Granada, Spain"}]},{"given":"Joana Paes","family":"de Faria","sequence":"additional","affiliation":[{"name":"Glial Cell Biology Laboratory, Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto, Porto, Portugal"}]},{"given":"Veronica","family":"Estrada","sequence":"additional","affiliation":[{"name":"Molecular Neurobiology Laboratory, Department of Neurology, University-Hospital D\u00fcsseldorf, Heinrich-Heine-University, D\u00fcsseldorf, Germany"}]},{"given":"Jo\u00e3o B.","family":"Relvas","sequence":"additional","affiliation":[{"name":"Glial Cell Biology Laboratory, Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto, Porto, Portugal"}]},{"given":"Hans W.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Molecular Neurobiology Laboratory, Department of Neurology, University-Hospital D\u00fcsseldorf, Heinrich-Heine-University, D\u00fcsseldorf, Germany"}]},{"given":"V\u00edctor","family":"Carriel","sequence":"additional","affiliation":[{"name":"Department of Histology & Tissue Engineering Group, University of Granada, Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Granada, Spain"}]},{"given":"Frank","family":"Bosse","sequence":"additional","affiliation":[{"name":"Molecular Neurobiology Laboratory, Department of Neurology, University-Hospital D\u00fcsseldorf, Heinrich-Heine-University, D\u00fcsseldorf, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1053-1107","authenticated-orcid":false,"given":"Sandra I.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal"}]}],"member":"276","published-online":{"date-parts":[[2024,12,7]]},"reference":[{"key":"R1-20260421","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1242\/jeb.95.1.231","article-title":"Influences of the glial environment on the elongation of axons after injury: transplantation studies in adult rodents","volume":"95","author":"Aguayo","year":"1981","journal-title":"J Exp Biol"},{"key":"R2-20260421","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1093\/neuros\/nyw080","article-title":"Traumatic spinal cord injury\u2014Repair and regeneration","volume":"80","author":"Ahuja","year":"2017","journal-title":"Neurosurgery"},{"key":"R3-20260421","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.neuron.2012.06.021","article-title":"c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration","volume":"75","author":"Arthur-Farraj","year":"2012","journal-title":"Neuron"},{"key":"R4-20260421","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1016\/j.celrep.2017.08.064","article-title":"Changes in the coding and non-coding transcriptome and DNA methylome that define the schwann cell repair phenotype after nerve injury","volume":"20","author":"Arthur-Farraj","year":"2017","journal-title":"Cell Rep"},{"key":"R5-20260421","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.bbi.2010.07.249","article-title":"Transcriptional profiling of the injured sciatic nerve of mice carrying the Wld(S) mutant gene: identification of genes involved in neuroprotection, neuroinflammation, and nerve regeneration","volume":"24","author":"Barrette","year":"2010","journal-title":"Brain Behav Immun"},{"key":"R6-20260421","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.colsurfb.2018.03.050","article-title":"Electrically polarized PLLA nanofibers as neural tissue engineering scaffolds with improved neuritogenesis","volume":"167","author":"Barroca","year":"2018","journal-title":"Colloids Surf B Biointerfaces"},{"key":"R7-20260421","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1523\/JNEUROSCI.1066-19.2019","article-title":"Autophagy in myelinating glia","volume":"40","author":"Belgrad","year":"2020","journal-title":"J Neurosci"},{"key":"R8-20260421","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1186\/s12864-020-06954-8","article-title":"Comparative gene expression profiling between optic nerve and spinal cord injury in Xenopus laevis reveals a core set of genes inherent in successful regeneration of vertebrate central nervous system axons","volume":"21","author":"Belrose","year":"2020","journal-title":"BMC Genomics"},{"key":"R9-20260421","doi-asserted-by":"crossref","first-page":"9489","DOI":"10.1074\/jbc.M808586200","article-title":"KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons","volume":"284","author":"Bisbal","year":"2009","journal-title":"J Biol Chem"},{"key":"R10-20260421","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1111\/j.1471-4159.2005.03635.x","article-title":"Gene expression profiling reveals that peripheral nerve regeneration is a consequence of both novel injury-dependent and reactivated developmental processes","volume":"96","author":"Bosse","year":"2006","journal-title":"J Neurochem"},{"key":"R11-20260421","first-page":"e53331","article-title":"Experimental strategies to bridge large tissue gaps in the injured spinal cord after acute and chronic lesion","author":"Brazda","year":"2016","journal-title":"J Vis Exp"},{"key":"R12-20260421","doi-asserted-by":"crossref","first-page":"E8072","DOI":"10.1073\/pnas.1710566114","article-title":"Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury","volume":"114","author":"Brosius Lutz","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R13-20260421","doi-asserted-by":"crossref","first-page":"026022","DOI":"10.1088\/1741-2560\/10\/2\/026022","article-title":"Combination of fibrin-agarose hydrogels and adipose-derived mesenchymal stem cells for peripheral nerve regeneration","volume":"10","author":"Carriel","year":"2013","journal-title":"J Neural Eng"},{"key":"R14-20260421","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.4103\/1673-5374.141798","article-title":"Histological assessment in peripheral nerve tissue engineering","volume":"9","author":"Carriel","year":"2014","journal-title":"Neural Regen Res"},{"key":"R15-20260421","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/term.1949","article-title":"Differential expression of GAP-43 and neurofilament during peripheral nerve regeneration through bio-artificial conduits","volume":"11","author":"Carriel","year":"2017","journal-title":"J Tissue Eng Regen Med"},{"key":"R16-20260421","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.4103\/1673-5374.211172","article-title":"Schwann cell development, maturation and regeneration: a focus on classic and emerging intracellular signaling pathways","volume":"12","author":"Castelnovo","year":"2017","journal-title":"Neural Regen Res"},{"key":"R17-20260421","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.cell.2015.07.021","article-title":"Macrophage-induced blood vessels guide Schwann cell-mediated regeneration of peripheral nerves","volume":"162","author":"Cattin","year":"2015","journal-title":"Cell"},{"key":"R18-20260421","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3389\/fncel.2018.00501","article-title":"In vivo evaluation of nanostructured fibrin-agarose hydrogels with mesenchymal stem cells for peripheral nerve repair","volume":"12","author":"Chato-Astrain","year":"2018","journal-title":"Front Cell Neurosci"},{"key":"R20-20260421","first-page":"1852","article-title":"Peripheral nerve regeneration through nerve conduits evokes differential expression of growth-associated protein-43 in the spinal cord","volume":"18","author":"Chato-Astrain","year":"2023","journal-title":"Neural Regen Res"},{"key":"R21-20260421","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s10571-020-00986-0","article-title":"Extracellular matrix in neural plasticity and regeneration","volume":"42","author":"Chelyshev","year":"2022","journal-title":"Cell Mol Neurobiol"},{"key":"R22-20260421","doi-asserted-by":"crossref","first-page":"e01792","DOI":"10.1002\/brb3.1792","article-title":"Berberine enhances L1 expression and axonal remyelination in rats after brachial plexus root avulsion","volume":"10","author":"Chen","year":"2020","journal-title":"Brain Behav"},{"key":"R23-20260421","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.1038\/s41598-018-37622-3","article-title":"Integrative analysis of KIF4A, 9, 18A, and 23 and their clinical significance in low-grade glioma and glioblastoma","volume":"9","author":"Cho","year":"2019","journal-title":"Sci Rep"},{"key":"R24-20260421","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neuron.2017.09.008","article-title":"The wound microenvironment reprograms Schwann cells to invasive mesenchymal-like cells to drive peripheral nerve regeneration","volume":"96","author":"Clements","year":"2017","journal-title":"Neuron"},{"key":"R25-20260421","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41583-020-0269-3","article-title":"Programmed axon degeneration: from mouse to mechanism to medicine","volume":"21","author":"Coleman","year":"2020","journal-title":"Nat Rev Neurosci"},{"key":"R26-20260421","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1126\/science.6171034","article-title":"Axonal elongation into peripheral nervous system \u201cbridges\u201d after central nervous system injury in adult rats","volume":"214","author":"David","year":"1981","journal-title":"Science"},{"key":"R27-20260421","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41536-021-00184-6","article-title":"Capacitive interdigitated system of high osteoinductive\/conductive performance for personalized acting-sensing implants","volume":"6","author":"de Sousa","year":"2021","journal-title":"NPJ Regen Med"},{"key":"R28-20260421","doi-asserted-by":"crossref","first-page":"W13","DOI":"10.1093\/nar\/gkr245","article-title":"T-Coffee: a web server for the multiple sequence alignment of protein and RNA sequences using structural information and homology extension","volume":"39","author":"Di Tommaso","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"R29-20260421","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1097\/BRS.0000000000004417","article-title":"Spinal cord injury: the global incidence, prevalence, and disability from the Global Burden of Disease Study 2019","volume":"47","author":"Ding","year":"2022","journal-title":"Spine (Phila Pa 1976)"},{"key":"R30-20260421","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0896-6273(95)90240-6","article-title":"A soluble chimeric form of the L1 glycoprotein stimulates neurite outgrowth","volume":"14","author":"Doherty","year":"1995","journal-title":"Neuron"},{"key":"R31-20260421","doi-asserted-by":"crossref","first-page":"e1007982","DOI":"10.1371\/journal.pgen.1007982","article-title":"Dynein promotes sustained axonal growth and Schwann cell remodeling early during peripheral nerve regeneration","volume":"15","author":"Ducommun Priest","year":"2019","journal-title":"PLoS Genet"},{"key":"R32-20260421","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/978-1-4939-7862-5_20","article-title":"Transection and crush models of nerve injury to measure repair and remyelination in peripheral nerve","volume":"1791","author":"Dun","year":"2018","journal-title":"Methods Mol Biol"},{"key":"R33-20260421","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/eye.2016.293","article-title":"An integrin approach to axon regeneration","volume":"31","author":"Fawcett","year":"2017","journal-title":"Eye (Lond)"},{"key":"R34-20260421","doi-asserted-by":"crossref","first-page":"e17907","DOI":"10.15252\/emmm.202317907","article-title":"Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury","volume":"15","author":"Fuentes-Flores","year":"2023","journal-title":"EMBO Mol Med"},{"key":"R35-20260421","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jneumeth.2015.01.021","article-title":"The sciatic nerve injury model in pre-clinical research","volume":"243","author":"Geuna","year":"2015","journal-title":"J Neurosci Methods"},{"key":"R36-20260421","doi-asserted-by":"crossref","first-page":"9086","DOI":"10.1523\/JNEUROSCI.1453-17.2017","article-title":"After nerve injury, lineage tracing shows that myelin and remak Schwann cells elongate extensively and branch to form repair Schwann cells, which shorten radically on remyelination","volume":"37","author":"Gomez-Sanchez","year":"2017","journal-title":"J Neurosci"},{"key":"R37-20260421","doi-asserted-by":"crossref","first-page":"8652","DOI":"10.3390\/ijms21228652","article-title":"Peripheral nerve regeneration and muscle reinnervation","volume":"21","author":"Gordon","year":"2020","journal-title":"Int J Mol Sci"},{"key":"R38-20260421","doi-asserted-by":"crossref","first-page":"11329","DOI":"10.1523\/JNEUROSCI.5221-12.2013","article-title":"The kinesin-2 family member KIF3C regulates microtubule dynamics and is required for axon growth and regeneration","volume":"33","author":"Gumy","year":"2013","journal-title":"J Neurosci"},{"key":"R39-20260421","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1093\/brain\/awp160","article-title":"Ablation of adhesion molecule L1 in mice favours Schwann cell proliferation and functional recovery after peripheral nerve injury","volume":"132","author":"Guseva","year":"2009","journal-title":"Brain"},{"key":"R40-20260421","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.4103\/1673-5374.197148","article-title":"Expression changes of nerve cell adhesion molecules L1 and semaphorin 3A after peripheral nerve injury","volume":"11","author":"He","year":"2016","journal-title":"Neural Regen Res"},{"key":"R41-20260421","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.mcn.2014.09.003","article-title":"Kinesin KIF4A transports integrin \u03b21 in developing axons of cortical neurons","volume":"63","author":"Heintz","year":"2014","journal-title":"Mol Cell Neurosci"},{"key":"R42-20260421","doi-asserted-by":"crossref","first-page":"e84212","DOI":"10.1371\/journal.pone.0084212","article-title":"Genome wide expression profiling during spinal cord regeneration identifies comprehensive cellular responses in zebrafish","volume":"9","author":"Hui","year":"2014","journal-title":"PLoS One"},{"key":"R43-20260421","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fncel.2019.00033","article-title":"The success and failure of the Schwann cell response to nerve injury","volume":"13","author":"Jessen","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"R44-20260421","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1002\/ajmg.a.62443","article-title":"Expanding the KIF4A-associated phenotype","volume":"185","author":"Kalantari","year":"2021","journal-title":"Am J Med Genet A"},{"key":"R45-20260421","doi-asserted-by":"crossref","first-page":"289","DOI":"10.5606\/ehc.2019.65584","article-title":"Is there an association of hematopoietic stem cell and endothelial progenitor cell markers with maturation in forearm arterial repair?","volume":"30","author":"Karaman","year":"2019","journal-title":"Eklem Hastalik Cerrahisi"},{"key":"R46-20260421","doi-asserted-by":"crossref","first-page":"e1703","DOI":"10.1002\/mgg3.1703","article-title":"Identification of microduplications at Xp21.2 and Xq13.1 in neurodevelopmental disorders","volume":"9","author":"Kokkonen","year":"2021","journal-title":"Mol Genet genomic Med"},{"key":"R47-20260421","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1749-8104-9-12","article-title":"Genome-wide expression profile of the response to spinal cord injury in Xenopus laevis reveals extensive differences between regenerative and non-regenerative stages","volume":"9","author":"Lee-Liu","year":"2014","journal-title":"Neural Dev"},{"key":"R48-20260421","doi-asserted-by":"crossref","first-page":"12762","DOI":"10.1523\/JNEUROSCI.1906-14.2014","article-title":"Perineurial glia are essential for motor axon regrowth following nerve injury","volume":"34","author":"Lewis","year":"2014","journal-title":"J Neurosci"},{"key":"R49-20260421","doi-asserted-by":"crossref","first-page":"e0123278","DOI":"10.1371\/journal.pone.0123278","article-title":"Specific marker expression and cell state of Schwann cells during culture in vitro","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS One"},{"key":"R50-20260421","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1111\/j.1471-4159.2004.02983.x","article-title":"Signal transduction pathways implicated in neural recognition molecule L1 triggered neuroprotection and neuritogenesis","volume":"92","author":"Loers","year":"2005","journal-title":"J Neurochem"},{"key":"R51-20260421","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1007\/s12035-015-9277-0","article-title":"Myelin basic protein cleaves cell adhesion molecule L1 and improves regeneration after injury","volume":"53","author":"Lutz","year":"2016","journal-title":"Mol Neurobiol"},{"key":"R52-20260421","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fnmol.2015.00043","article-title":"What makes a RAG regeneration associated?","volume":"8","author":"Ma","year":"2015","journal-title":"Front Mol Neurosci"},{"key":"R53-20260421","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1016\/j.stemcr.2022.10.002","article-title":"Satellite glia of the adult dorsal root ganglia harbor stem cells that yield glia under physiological conditions and neurons in response to injury","volume":"17","author":"Maniglier","year":"2022","journal-title":"Stem Cell Reports"},{"key":"R54-20260421","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3934\/molsci.2016.4.661","article-title":"A proteomic analysis of the interactions between poly(L-lactic acid) nanofibers and SH-SY5Y neuronal-like cells","volume":"3","author":"Marote","year":"2016","journal-title":"AIMS Mol Sci"},{"key":"R55-20260421","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1046\/j.1460-9568.2003.02809.x","article-title":"Corticospinal neurons up-regulate a range of growth-associated genes following intracortical, but not spinal, axotomy","volume":"18","author":"Mason","year":"2003","journal-title":"Eur J Neurosci"},{"key":"R56-20260421","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.cell.2006.02.039","article-title":"KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity","volume":"125","author":"Midorikawa","year":"2006","journal-title":"Cell"},{"key":"R57-20260421","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1529-8027.2008.00168.x","article-title":"Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiation","volume":"13","author":"Mirsky","year":"2008","journal-title":"J Peripher Nerv Syst"},{"key":"R58-20260421","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13064-020-0138-9","article-title":"Evaluating the effectiveness of anti-Nogo treatment in spinal cord injuries","volume":"15","author":"Mohammed","year":"2020","journal-title":"Neural Dev"},{"key":"R59-20260421","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1093\/brain\/awl184","article-title":"Comparison of the fastest regenerating motor and sensory myelinated axons in the same peripheral nerve","volume":"129","author":"Moldovan","year":"2006","journal-title":"Brain"},{"key":"R60-20260421","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/978-1-61779-442-1_20","article-title":"Identification of new interacting partners for atypical Rho GTPases: a SILAC-based approach","volume":"827","author":"Montani","year":"2012","journal-title":"Methods Mol Biol"},{"key":"R61-20260421","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.neuron.2014.06.016","article-title":"Diminished Schwann cell repair responses underlie age-associated impaired axonal regeneration","volume":"83","author":"Painter","year":"2014","journal-title":"Neuron"},{"key":"R62-20260421","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1083\/jcb.149.1.141","article-title":"Evidence for the involvement of KIF4 in the anterograde transport of L1-containing vesicles","volume":"149","author":"Peretti","year":"2000","journal-title":"J Cell Biol"},{"key":"R63-20260421","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/dneu.22608","article-title":"The virtuous cycle of axon growth: axonal transport of growth-promoting machinery as an intrinsic determinant of axon regeneration","volume":"78","author":"Petrova","year":"2018","journal-title":"Dev Neurobiol"},{"key":"R64-20260421","doi-asserted-by":"crossref","first-page":"5715","DOI":"10.1007\/s12035-019-1494-5","article-title":"Non-peptidergic nociceptive neurons are essential for mechanical inflammatory hypersensitivity in mice","volume":"56","author":"Pinto","year":"2019","journal-title":"Mol Neurobiol"},{"key":"R65-20260421","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1093\/brain\/awad047","article-title":"Cell therapies for spinal cord injury: a review of the clinical trials and cell-type therapeutic potential","volume":"146","author":"Ribeiro","year":"2023","journal-title":"Brain"},{"key":"R66-20260421","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1369\/0022155414530994","article-title":"Characterization of endoneurial fibroblast-like cells from human and rat peripheral nerves","volume":"62","author":"Richard","year":"2014","journal-title":"J Histochem Cytochem"},{"key":"R67-20260421","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.proghi.2016.05.001","article-title":"L1CAM: Cell adhesion and more","volume":"51","author":"Samatov","year":"2016","journal-title":"Prog Histochem Cytochem"},{"key":"R68-20260421","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1083\/jcb.201202155","article-title":"Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase II\u03b1","volume":"199","author":"Samejima","year":"2012","journal-title":"J Cell Biol"},{"key":"R69-20260421","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/glia.20910","article-title":"Sciatic nerve injury induces apoptosis of dorsal root ganglion satellite glial cells and selectively modifies neurosteroidogenesis in sensory neurons","volume":"58","author":"Schaeffer","year":"2010","journal-title":"Glia"},{"key":"R70-20260421","doi-asserted-by":"crossref","first-page":"10311","DOI":"10.3390\/ijms231810311","article-title":"Modulation of specific sphingosine-1-phosphate receptors augments a repair mediating Schwann cell phenotype","volume":"23","author":"Schira-Heinen","year":"2022","journal-title":"Int J Mol Sci"},{"key":"R71-20260421","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1016\/S0140-6736(05)66699-8","article-title":"Injury-related dynamic myelin\/oligodendrocyte axon-outgrowth inhibition in the central nervous system","volume":"365","author":"Schwab","year":"2005","journal-title":"Lancet"},{"key":"R72-20260421","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"R73-20260421","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.gene.2018.08.005","article-title":"The multiple functions of kinesin-4 family motor protein KIF4 and its clinical potential","volume":"678","author":"Sheng","year":"2018","journal-title":"Gene"},{"key":"R74-20260421","doi-asserted-by":"crossref","first-page":"146864","DOI":"10.1016\/j.brainres.2020.146864","article-title":"Intra-axonal mechanisms driving axon regeneration","volume":"1740","author":"Smith","year":"2020","journal-title":"Brain Res"},{"key":"R75-20260421","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/dneu.22771","article-title":"Axo\u2010glial interaction in the injured PNS","volume":"81","author":"Stassart","year":"2021","journal-title":"Dev Neurobiol"},{"key":"R76-20260421","doi-asserted-by":"crossref","first-page":"dev170316","DOI":"10.1242\/dev.170316","article-title":"The regulation of the homeostasis and regeneration of peripheral nerve is distinct from the CNS and independent of a stem cell population","volume":"145","author":"Stierli","year":"2018","journal-title":"Development"},{"key":"R77-20260421","doi-asserted-by":"crossref","first-page":"888523","DOI":"10.3389\/fnmol.2022.888523","article-title":"Expression of Protein Acetylation Regulators During Peripheral Nerve Development, Injury, and Regeneration","volume":"15","author":"Sun","year":"2022","journal-title":"Front Mol Neurosci"},{"key":"R78-20260421","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/glia.20767","article-title":"The molecular machinery of myelin gene transcription in Schwann cells","volume":"56","author":"Svaren","year":"2008","journal-title":"Glia"},{"key":"R79-20260421","doi-asserted-by":"crossref","first-page":"D362","DOI":"10.1093\/nar\/gkw937","article-title":"The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible","volume":"45","author":"Szklarczyk","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"R80-20260421","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1523\/JNEUROSCI.16-01-00031.1996","article-title":"mRNA expression of KIF1A, KIF1B, KIF2, KIF3A, KIF3B, KIF4, KIF5, and cytoplasmic dynein during axonal regeneration","volume":"16","author":"Takemura","year":"1996","journal-title":"J Neurosci"},{"key":"R81-20260421","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1038\/s41596-024-00997-x","article-title":"Real-time imaging of axonal membrane protein life cycles","volume":"19","author":"Tyagi","year":"2024","journal-title":"Nat Protoc"},{"key":"R82-20260421","doi-asserted-by":"crossref","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"R83-20260421","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/B978-0-444-52137-8.00037-1","article-title":"Molecular target discovery for neural repair in the functional genomics era","volume":"109","author":"Verhaagen","year":"2012","journal-title":"Handb Clin Neurol"},{"key":"R84-20260421","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4103\/1673-5374.244797","article-title":"A novel primary culture method for high-purity satellite glial cells derived from rat dorsal root ganglion","volume":"14","author":"Wang","year":"2019","journal-title":"Neural Regen Res"},{"key":"R85-20260421","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1136\/jmedgenet-2013-102182","article-title":"Involvement of the kinesin family members KIF4A and KIF5C in intellectual disability and synaptic function","volume":"51","author":"Willemsen","year":"2014","journal-title":"J Med Genet"},{"key":"R86-20260421","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.4161\/cc.7.13.6130","article-title":"A novel role of the chromokinesin Kif4A in DNA damage response","volume":"7","author":"Wu","year":"2008","journal-title":"Cell Cycle"},{"key":"R87-20260421","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s13311-011-0028-2","article-title":"Cell cycle activation and spinal cord injury","volume":"8","author":"Wu","year":"2011","journal-title":"Neurotherapeutics"},{"key":"R88-20260421","doi-asserted-by":"crossref","first-page":"e0127772","DOI":"10.1371\/journal.pone.0127772","article-title":"Intrathecal delivery of IL-6 reactivates the intrinsic growth capacity of pyramidal cells in the sensorimotor cortex after spinal cord injury","volume":"10","author":"Yang","year":"2015","journal-title":"PLoS One"},{"key":"R89-20260421","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1186\/s12864-019-6244-6","article-title":"Transcriptomic analysis of \u03b1-synuclein knockdown after T3 spinal cord injury in rats","volume":"20","author":"Zeng","year":"2019","journal-title":"BMC Genomics"},{"key":"R90-20260421","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s12035-022-03090-0","article-title":"Transcriptional control of peripheral nerve regeneration","volume":"60","author":"Zhang","year":"2023","journal-title":"Mol Neurobiol"},{"key":"R91-20260421","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1073\/pnas.0408438102","article-title":"Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis","volume":"102","author":"Zhu","year":"2005","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/NRR.NRR-D-24-00232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T15:24:03Z","timestamp":1776785043000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.4103\/NRR.NRR-D-24-00232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,7]]},"references-count":90,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/nrr.nrr-d-24-00232","relation":{},"ISSN":["1673-5374","1876-7958"],"issn-type":[{"value":"1673-5374","type":"print"},{"value":"1876-7958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,7]]},"assertion":[{"value":"2024-02-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-16","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}