{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:44:23Z","timestamp":1784241863784,"version":"3.55.0"},"reference-count":66,"publisher":"XMLink","issue":"2","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021RIS-001"],"award-info":[{"award-number":["2021RIS-001"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["immunenetwork.org"],"crossmark-restriction":false},"short-container-title":["Immune Netw"],"DOI":"10.4110\/in.2025.25.e5","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T06:47:26Z","timestamp":1745995646000},"update-policy":"https:\/\/doi.org\/10.4110\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Anti-arthritis Effect of Anti-chitinase-3-like 1 Antibody Through Inhibition of MMP3"],"prefix":"10.4110","volume":"25","author":[{"given":"Dae Hwan","family":"Kim","sequence":"first","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9382-6914","authenticated-orcid":false,"given":"Ji Eun","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Chonnam National University, Gwangju 61186, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Ji","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hee","family":"Jeon","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaesuk","family":"Yun","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7520-6909","authenticated-orcid":false,"given":"Dong Ju","family":"Son","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bongcheol","family":"Kim","sequence":"additional","affiliation":[{"name":"Senelix Co., Seoul 05836, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Ji","family":"Yong","sequence":"additional","affiliation":[{"name":"Prestige Biologics Co., Cheongju 28161, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-soo","family":"Lim","sequence":"additional","affiliation":[{"name":"Prestige Biologics Co., Cheongju 28161, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Hun","family":"Kim","sequence":"additional","affiliation":[{"name":"Autotelic Bio Co., Cheongju 28160, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azizi Mohammad","family":"Khalid","sequence":"additional","affiliation":[{"name":"Medical Team & Innovation Center, Bestian Hospital, Cheongju 28161, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6656-6523","authenticated-orcid":false,"given":"Sang-Bae","family":"Han","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4616-2622","authenticated-orcid":false,"given":"Yong Sun","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6534-9575","authenticated-orcid":false,"given":"Jin Tae","family":"Hong","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18617","published-online":{"date-parts":[[2025]]},"reference":[{"key":"10.4110\/in.2025.25.e5_ref1","doi-asserted-by":"crossref","first-page":"18001","DOI":"10.1038\/nrdp.2018.1","volume":"4","author":"Smolen","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"10.4110\/in.2025.25.e5_ref2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41413-018-0016-9","volume":"6","author":"Guo","year":"2018","journal-title":"Bone Res"},{"key":"10.4110\/in.2025.25.e5_ref3","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev-physiol-012110-142250","volume":"73","author":"Lee","year":"2011","journal-title":"Annu Rev Physiol"},{"key":"10.4110\/in.2025.25.e5_ref4","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41392-020-00303-7","volume":"5","author":"Zhao","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"10.4110\/in.2025.25.e5_ref5","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1080\/10408360802334743","volume":"45","author":"Coffman","year":"2008","journal-title":"Crit Rev Clin Lab Sci"},{"key":"10.4110\/in.2025.25.e5_ref6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1742-2094-7-34","volume":"7","author":"Bonneh-Barkay","year":"2010","journal-title":"J Neuroinflammation"},{"key":"10.4110\/in.2025.25.e5_ref7","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4078\/jrd.2019.26.4.257","volume":"26","author":"Lee","year":"2019","journal-title":"J Rheum Dis"},{"key":"10.4110\/in.2025.25.e5_ref8","doi-asserted-by":"crossref","first-page":"793835","DOI":"10.3389\/fncel.2022.793835","volume":"16","author":"Ham","year":"2022","journal-title":"Front Cell Neurosci"},{"key":"10.4110\/in.2025.25.e5_ref9","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.4110\/in.2021.21.e22","volume":"21","author":"Jeon","year":"2021","journal-title":"Immune Netw"},{"key":"10.4110\/in.2025.25.e5_ref10","doi-asserted-by":"crossref","first-page":"e739","DOI":"10.1002\/ctm2.739","volume":"12","author":"Lee","year":"2022","journal-title":"Clin Transl Med"},{"key":"10.4110\/in.2025.25.e5_ref11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.molimm.2023.02.012","volume":"156","author":"Kim","year":"2023","journal-title":"Mol Immunol"},{"key":"10.4110\/in.2025.25.e5_ref12","doi-asserted-by":"crossref","first-page":"905","DOI":"10.3390\/ijms18050905","volume":"18","author":"Araki","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.4110\/in.2025.25.e5_ref13","doi-asserted-by":"crossref","first-page":"663978","DOI":"10.3389\/fphys.2021.663978","volume":"12","author":"Wan","year":"2021","journal-title":"Front Physiol"},{"key":"10.4110\/in.2025.25.e5_ref14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1423-0127-18-86","volume":"18","author":"Chao","year":"2011","journal-title":"J Biomed Sci"},{"key":"10.4110\/in.2025.25.e5_ref15","doi-asserted-by":"crossref","first-page":"R118","DOI":"10.1186\/ar1462","volume":"7","author":"Zeisel","year":"2004","journal-title":"Arthritis Res Ther"},{"key":"10.4110\/in.2025.25.e5_ref16","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1161\/01.ATV.0000015078.09208.92","volume":"22","author":"Chase","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.4110\/in.2025.25.e5_ref17","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.matbio.2010.02.004","volume":"29","author":"Leong","year":"2010","journal-title":"Matrix Biol"},{"key":"10.4110\/in.2025.25.e5_ref18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/art.22337","volume":"56","author":"Blom","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.4110\/in.2025.25.e5_ref19","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1186\/s13075-017-1449-z","volume":"19","author":"Zhou","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"10.4110\/in.2025.25.e5_ref20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10067-017-3829-9","volume":"38","author":"Hattori","year":"2019","journal-title":"Clin Rheumatol"},{"key":"10.4110\/in.2025.25.e5_ref21","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3389\/fphys.2013.00392","volume":"4","author":"Libreros","year":"2013","journal-title":"Front Physiol"},{"key":"10.4110\/in.2025.25.e5_ref22","doi-asserted-by":"crossref","first-page":"215140","DOI":"10.1155\/2014\/215140","volume":"2014","author":"V\u00e4\u00e4n\u00e4nen","year":"2014","journal-title":"Mediators Inflamm"},{"key":"10.4110\/in.2025.25.e5_ref23","doi-asserted-by":"crossref","first-page":"6354","DOI":"10.3390\/ijms21176354","volume":"21","author":"Kang","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.4110\/in.2025.25.e5_ref24","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1002\/1878-0261.13152","volume":"16","author":"Yu","year":"2022","journal-title":"Mol Oncol"},{"key":"10.4110\/in.2025.25.e5_ref25","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1111\/bph.12619","volume":"171","author":"Ban","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.4110\/in.2025.25.e5_ref26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/s13046-018-0943-8","volume":"37","author":"Lee","year":"2018","journal-title":"J Exp Clin Cancer Res"},{"key":"10.4110\/in.2025.25.e5_ref27","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.7150\/thno.26467","volume":"8","author":"Kim","year":"2018","journal-title":"Theranostics"},{"key":"10.4110\/in.2025.25.e5_ref28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12929-017-0383-3","volume":"24","author":"Devarapu","year":"2017","journal-title":"J Biomed Sci"},{"key":"10.4110\/in.2025.25.e5_ref29","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13148-023-01426-8","volume":"15","author":"Wang","year":"2023","journal-title":"Clin Epigenetics"},{"key":"10.4110\/in.2025.25.e5_ref30","first-page":"e930053","volume":"27","author":"Wang","year":"2021","journal-title":"Med Sci Monit"},{"key":"10.4110\/in.2025.25.e5_ref31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12974-016-0540-8","volume":"13","author":"Martini","year":"2016","journal-title":"J Neuroinflammation"},{"key":"10.4110\/in.2025.25.e5_ref32","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.4049\/jimmunol.1500352","volume":"195","author":"Bardina","year":"2015","journal-title":"J Immunol"},{"key":"10.4110\/in.2025.25.e5_ref33","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1016\/j.ymthe.2023.10.016","volume":"31","author":"Fang","year":"2023","journal-title":"Mol Ther"},{"key":"10.4110\/in.2025.25.e5_ref34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ccell.2016.06.002","volume":"30","author":"H\u00f6ckendorf","year":"2016","journal-title":"Cancer Cell"},{"key":"10.4110\/in.2025.25.e5_ref35","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1038\/mt.2009.182","volume":"17","author":"Geurts","year":"2009","journal-title":"Mol Ther"},{"key":"10.4110\/in.2025.25.e5_ref36","doi-asserted-by":"crossref","first-page":"860","DOI":"10.4049\/jimmunol.1400045","volume":"193","author":"Sun","year":"2014","journal-title":"J Immunol"},{"key":"10.4110\/in.2025.25.e5_ref37","doi-asserted-by":"crossref","first-page":"W214","DOI":"10.1093\/nar\/gkq537","volume":"38","author":"Warde-Farley","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.4110\/in.2025.25.e5_ref38","doi-asserted-by":"crossref","first-page":"867260","DOI":"10.3389\/fimmu.2022.867260","volume":"13","author":"Cutolo","year":"2022","journal-title":"Front Immunol"},{"key":"10.4110\/in.2025.25.e5_ref39","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1471-2474-15-93","volume":"15","author":"Sun","year":"2014","journal-title":"BMC Musculoskelet Disord"},{"key":"10.4110\/in.2025.25.e5_ref40","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1002\/art.25006","volume":"60","author":"Joosten","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.4110\/in.2025.25.e5_ref41","first-page":"144","volume":"30","author":"Casc\u00e3o","year":"2012","journal-title":"Clin Exp Rheumatol"},{"key":"10.4110\/in.2025.25.e5_ref42","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/1878-0261.13138","volume":"16","author":"Lee","year":"2022","journal-title":"Mol Oncol"},{"key":"10.4110\/in.2025.25.e5_ref43","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/rheumatology\/38.7.618","volume":"38","author":"Johansen","year":"1999","journal-title":"Rheumatology (Oxford)"},{"key":"10.4110\/in.2025.25.e5_ref44","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1053\/joca.2000.0377","volume":"9","author":"Volck","year":"2001","journal-title":"Osteoarthritis Cartilage"},{"key":"10.4110\/in.2025.25.e5_ref45","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1186\/s12974-020-02022-w","volume":"17","author":"Ham","year":"2020","journal-title":"J Neuroinflammation"},{"key":"10.4110\/in.2025.25.e5_ref46","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/00002281-199905000-00009","volume":"11","author":"Amin","year":"1999","journal-title":"Curr Opin Rheumatol"},{"issue":"Suppl 3","key":"10.4110\/in.2025.25.e5_ref47","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1186\/ar572","volume":"4","author":"Murphy","year":"2002","journal-title":"Arthritis Res"},{"key":"10.4110\/in.2025.25.e5_ref48","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3892\/mmr.2022.12615","volume":"25","author":"Liu","year":"2022","journal-title":"Mol Med Rep"},{"key":"10.4110\/in.2025.25.e5_ref49","doi-asserted-by":"crossref","first-page":"e0183294","DOI":"10.1371\/journal.pone.0183294","volume":"12","author":"V\u00e4\u00e4n\u00e4nen","year":"2017","journal-title":"PLoS One"},{"key":"10.4110\/in.2025.25.e5_ref50","first-page":"448","volume":"18","author":"Waszczykowski","year":"2020","journal-title":"Arch Med Sci"},{"key":"10.4110\/in.2025.25.e5_ref51","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13018-020-01595-9","volume":"15","author":"Kanai","year":"2020","journal-title":"J Orthop Surg"},{"key":"10.4110\/in.2025.25.e5_ref52","doi-asserted-by":"crossref","first-page":"6033","DOI":"10.1038\/s41598-022-10012-6","volume":"12","author":"Konishi","year":"2022","journal-title":"Sci Rep"},{"key":"10.4110\/in.2025.25.e5_ref53","doi-asserted-by":"crossref","first-page":"e9902","DOI":"10.1371\/journal.pone.0009902","volume":"5","author":"Souslova","year":"2010","journal-title":"PLoS One"},{"key":"10.4110\/in.2025.25.e5_ref54","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3892\/etm.2021.9819","volume":"21","author":"Zhang","year":"2021","journal-title":"Exp Ther Med"},{"key":"10.4110\/in.2025.25.e5_ref55","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ni.1703","volume":"10","author":"Franchi","year":"2009","journal-title":"Nat Immunol"},{"key":"10.4110\/in.2025.25.e5_ref56","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.3390\/ijms17111825","volume":"17","author":"Van Hove","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.4110\/in.2025.25.e5_ref57","doi-asserted-by":"crossref","first-page":"540669","DOI":"10.3389\/fncel.2020.540669","volume":"14","author":"Liang","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"10.4110\/in.2025.25.e5_ref58","doi-asserted-by":"crossref","first-page":"646386","DOI":"10.3389\/fcell.2021.646386","volume":"9","author":"Tao","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.4110\/in.2025.25.e5_ref59","doi-asserted-by":"crossref","first-page":"e24591","DOI":"10.1371\/journal.pone.0024591","volume":"6","author":"Garc\u00eda-Arnandis","year":"2011","journal-title":"PLoS One"},{"key":"10.4110\/in.2025.25.e5_ref60","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1111\/cea.13478","volume":"49","author":"Kwak","year":"2019","journal-title":"Clin Exp Allergy"},{"key":"10.4110\/in.2025.25.e5_ref61","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.4168\/aair.2020.12.6.1012","volume":"12","author":"Kim","year":"2020","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.4110\/in.2025.25.e5_ref62","doi-asserted-by":"crossref","first-page":"115802","DOI":"10.1016\/j.jep.2022.115802","volume":"301","author":"Lin","year":"2023","journal-title":"J Ethnopharmacol"},{"key":"10.4110\/in.2025.25.e5_ref63","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1002\/art.38743","volume":"66","author":"Sekine","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.4110\/in.2025.25.e5_ref64","doi-asserted-by":"crossref","first-page":"680043","DOI":"10.3389\/fphar.2021.680043","volume":"12","author":"Shams","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.4110\/in.2025.25.e5_ref65","doi-asserted-by":"crossref","first-page":"e14181","DOI":"10.1097\/MD.0000000000014181","volume":"98","author":"Santos-Moreno","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"10.4110\/in.2025.25.e5_ref66","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1196\/annals.1398.034","volume":"1109","author":"Bobbio-Pallavicini","year":"2007","journal-title":"Ann N Y Acad Sci"}],"container-title":["Immune Network"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/immunenetwork.org\/pdf\/10.4110\/in.2025.25.e5","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/immunenetwork.org\/DOIx.php?id=10.4110\/in.2025.25.e5","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/immunenetwork.org\/DOIx.php?id=10.4110\/in.2025.25.e5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T06:51:17Z","timestamp":1745995877000},"score":1,"resource":{"primary":{"URL":"https:\/\/immunenetwork.org\/DOIx.php?id=10.4110\/in.2025.25.e5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":66,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4110\/in.2025.25.e5","relation":{},"ISSN":["1598-2629","2092-6685"],"issn-type":[{"value":"1598-2629","type":"print"},{"value":"2092-6685","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"2024-09-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-30","name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-07","name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"Copyright \u00a9 2025. The Korean Association of Immunologists","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}],"article-number":"e5"}}