{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:20:31Z","timestamp":1790688031612,"version":"4.1.0"},"reference-count":78,"publisher":"XMLink","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["icurology.org"],"crossmark-restriction":false},"short-container-title":["Investig Clin Urol"],"published-print":{"date-parts":[[2021]]},"DOI":"10.4111\/icu.20200395","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T05:24:13Z","timestamp":1609219453000},"page":"1","update-policy":"https:\/\/doi.org\/10.4111\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Clinical utility of current biomarkers for prostate cancer detection"],"prefix":"10.4111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8942-0188","authenticated-orcid":false,"given":"Jeong Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Urology, Kangwon National University School of Medicine, Chuncheon, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8344-6774","authenticated-orcid":false,"given":"Sung Kyu","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Urology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18617","reference":[{"key":"10.4111\/icu.20200395_ref1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3122\/jabfm.16.2.95","volume":"16","author":"Mistry","year":"2003","journal-title":"J Am Board Fam Pract"},{"key":"10.4111\/icu.20200395_ref2","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.ejca.2004.12.029","volume":"41","author":"Postma","year":"2005","journal-title":"Eur J Cancer"},{"key":"10.4111\/icu.20200395_ref3","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/jnci\/djj131","volume":"98","author":"Thompson","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"10.4111\/icu.20200395_ref4","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0022-5347(05)65416-X","volume":"167","author":"Peyromaure","year":"2002","journal-title":"J Urol"},{"key":"10.4111\/icu.20200395_ref5","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/jnci\/djp001","volume":"101","author":"Draisma","year":"2009","journal-title":"J Natl Cancer Inst"},{"key":"10.4111\/icu.20200395_ref6","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1056\/NEJMoa0810084","volume":"360","author":"Schr\u00f6der","year":"2009","journal-title":"N Engl J Med"},{"key":"10.4111\/icu.20200395_ref7","doi-asserted-by":"crossref","first-page":"449","DOI":"10.7326\/M16-2586","volume":"167","author":"Tsodikov","year":"2017","journal-title":"Ann Intern Med"},{"key":"10.4111\/icu.20200395_ref8","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/ncpuro0993","volume":"5","author":"Klotz","year":"2008","journal-title":"Nat Clin Pract Urol"},{"key":"10.4111\/icu.20200395_ref9","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/nrurol.2011.50","volume":"8","author":"Lawrentschuk","year":"2011","journal-title":"Nat Rev Urol"},{"key":"10.4111\/icu.20200395_ref10","first-page":"366","volume":"107","author":"Heijnsdijk","year":"2014","journal-title":"J Natl Cancer Inst"},{"key":"10.4111\/icu.20200395_ref11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.eururo.2013.06.051","volume":"64","author":"Heidenreich","year":"2013","journal-title":"Eur Urol"},{"key":"10.4111\/icu.20200395_ref12","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/bju.12556","volume":"113","author":"Murphy","year":"2014","journal-title":"BJU Int"},{"key":"10.4111\/icu.20200395_ref13","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1093\/annonc\/mdu525","volume":"26","author":"Louie","year":"2015","journal-title":"Ann Oncol"},{"key":"10.4111\/icu.20200395_ref14","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.2174\/0929867325666180914115416","volume":"26","author":"Anceschi","year":"2019","journal-title":"Curr Med Chem"},{"key":"10.4111\/icu.20200395_ref15","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0140-6736(16)32401-1","volume":"389","author":"Ahmed","year":"2017","journal-title":"Lancet"},{"key":"10.4111\/icu.20200395_ref16","doi-asserted-by":"crossref","first-page":"509","DOI":"10.6004\/jnccn.2016.0060","volume":"14","author":"Carroll","year":"2016","journal-title":"J Natl Compr Canc Netw"},{"key":"10.4111\/icu.20200395_ref17","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.3390\/ijms20071637","volume":"20","author":"Osses","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.4111\/icu.20200395_ref18","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0090-4295(01)01605-3","volume":"59","author":"Mikolajczyk","year":"2002","journal-title":"Urology"},{"key":"10.4111\/icu.20200395_ref19","first-page":"83","volume":"11","author":"Filella","year":"2018","journal-title":"Pharmgenomics Pers Med"},{"key":"10.4111\/icu.20200395_ref20","first-page":"756","volume":"60","author":"Mikolajczyk","year":"2000","journal-title":"Cancer Res"},{"key":"10.4111\/icu.20200395_ref21","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0090-4295(97)00449-4","volume":"50","author":"Mikolajczyk","year":"1997","journal-title":"Urology"},{"key":"10.4111\/icu.20200395_ref22","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1464-410X.2012.11329.x","volume":"112","author":"Hori","year":"2013","journal-title":"BJU Int"},{"key":"10.4111\/icu.20200395_ref23","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.juro.2010.12.032","volume":"185","author":"Catalona","year":"2011","journal-title":"J Urol"},{"key":"10.4111\/icu.20200395_ref24","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.eururo.2010.02.003","volume":"57","author":"Jansen","year":"2010","journal-title":"Eur Urol"},{"key":"10.4111\/icu.20200395_ref25","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1158\/1055-9965.EPI-10-0007","volume":"19","author":"Sokoll","year":"2010","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.4111\/icu.20200395_ref26","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.eururo.2011.03.052","volume":"60","author":"Guazzoni","year":"2011","journal-title":"Eur Urol"},{"key":"10.4111\/icu.20200395_ref27","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.juro.2012.06.017","volume":"188","author":"Lazzeri","year":"2012","journal-title":"J Urol"},{"key":"10.4111\/icu.20200395_ref28","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/bju.12217","volume":"112","author":"Lazzeri","year":"2013","journal-title":"BJU Int"},{"key":"10.4111\/icu.20200395_ref29","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1373\/clinchem.2012.195784","volume":"59","author":"Stephan","year":"2013","journal-title":"Clin Chem"},{"key":"10.4111\/icu.20200395_ref30","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.3346\/jkms.2018.33.e94","volume":"33","author":"Park","year":"2018","journal-title":"J Korean Med Sci"},{"key":"10.4111\/icu.20200395_ref31","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.eururo.2016.08.003","volume":"71","author":"Mottet","year":"2017","journal-title":"Eur Urol"},{"key":"10.4111\/icu.20200395_ref32","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/MOU.0000000000000316","volume":"26","author":"Loeb","year":"2016","journal-title":"Curr Opin Urol"},{"key":"10.4111\/icu.20200395_ref33","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/bju.13139","volume":"117","author":"Boegemann","year":"2016","journal-title":"BJU Int"},{"key":"10.4111\/icu.20200395_ref34","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.juro.2015.01.091","volume":"194","author":"de la Calle","year":"2015","journal-title":"J Urol"},{"key":"10.4111\/icu.20200395_ref35","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.juro.2012.06.025","volume":"188","author":"Lughezzani","year":"2012","journal-title":"J Urol"},{"key":"10.4111\/icu.20200395_ref36","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/bju.13143","volume":"117","author":"Foley","year":"2016","journal-title":"BJU Int"},{"key":"10.4111\/icu.20200395_ref37","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/bju.13676","volume":"120","author":"Loeb","year":"2017","journal-title":"BJU Int"},{"key":"10.4111\/icu.20200395_ref38","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ajur.2016.08.010","volume":"4","author":"Zhang","year":"2017","journal-title":"Asian J Urol"},{"key":"10.4111\/icu.20200395_ref39","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1741-7015-6-19","volume":"6","author":"Vickers","year":"2008","journal-title":"BMC Med"},{"key":"10.4111\/icu.20200395_ref40","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1200\/JCO.2009.24.1968","volume":"28","author":"Vickers","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.4111\/icu.20200395_ref41","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1158\/1078-0432.CCR-10-0122","volume":"16","author":"Vickers","year":"2010","journal-title":"Clin Cancer Res"},{"key":"10.4111\/icu.20200395_ref42","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/sj.bjc.6605815","volume":"103","author":"Gupta","year":"2010","journal-title":"Br J Cancer"},{"key":"10.4111\/icu.20200395_ref43","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.eururo.2014.10.021","volume":"68","author":"Parekh","year":"2015","journal-title":"Eur Urol"},{"key":"10.4111\/icu.20200395_ref44","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.eururo.2015.04.028","volume":"69","author":"Braun","year":"2016","journal-title":"Eur Urol"},{"key":"10.4111\/icu.20200395_ref45","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.eururo.2016.11.017","volume":"72","author":"Lin","year":"2017","journal-title":"Eur Urol"},{"key":"10.4111\/icu.20200395_ref46","first-page":"149","volume":"19","author":"Zappala","year":"2017","journal-title":"Rev Urol"},{"key":"10.4111\/icu.20200395_ref47","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.eururo.2014.08.010","volume":"68","author":"Nordstr\u00f6m","year":"2015","journal-title":"Eur Urol"},{"key":"10.4111\/icu.20200395_ref48","first-page":"5975","volume":"59","author":"Bussemakers","year":"1999","journal-title":"Cancer Res"},{"key":"10.4111\/icu.20200395_ref49","first-page":"2695","volume":"62","author":"de Kok","year":"2002","journal-title":"Cancer Res"},{"key":"10.4111\/icu.20200395_ref50","doi-asserted-by":"crossref","first-page":"25776","DOI":"10.1038\/srep25776","volume":"6","author":"Cui","year":"2016","journal-title":"Sci Rep"},{"key":"10.4111\/icu.20200395_ref51","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.urology.2006.12.014","volume":"69","author":"Marks","year":"2007","journal-title":"Urology"},{"key":"10.4111\/icu.20200395_ref52","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/pros.20781","volume":"68","author":"van Gils","year":"2008","journal-title":"Prostate"},{"key":"10.4111\/icu.20200395_ref53","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.eururo.2010.10.024","volume":"59","author":"Auprich","year":"2011","journal-title":"Eur Urol"},{"key":"10.4111\/icu.20200395_ref54","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/pros.22898","volume":"75","author":"Seisen","year":"2015","journal-title":"Prostate"},{"key":"10.4111\/icu.20200395_ref55","doi-asserted-by":"crossref","first-page":"163.e15","DOI":"10.1016\/j.urolonc.2014.12.002","volume":"33","author":"Cantiello","year":"2015","journal-title":"Urol Oncol"},{"key":"10.4111\/icu.20200395_ref56","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/pros.21265","volume":"71","author":"Magi-Galluzzi","year":"2011","journal-title":"Prostate"},{"key":"10.4111\/icu.20200395_ref57","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.1158\/1078-0432.CCR-07-0700","volume":"13","author":"Hessels","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.4111\/icu.20200395_ref58","doi-asserted-by":"crossref","first-page":"94ra72","DOI":"10.1126\/scitranslmed.3001970","volume":"3","author":"Tomlins","year":"2011","journal-title":"Sci Transl Med"},{"key":"10.4111\/icu.20200395_ref59","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1038\/sj.onc.1210237","volume":"26","author":"Demichelis","year":"2007","journal-title":"Oncogene"},{"key":"10.4111\/icu.20200395_ref60","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/pros.22546","volume":"73","author":"Robert","year":"2013","journal-title":"Prostate"},{"key":"10.4111\/icu.20200395_ref61","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.urolonc.2011.04.001","volume":"31","author":"Salami","year":"2013","journal-title":"Urol Oncol"},{"key":"10.4111\/icu.20200395_ref62","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.eururo.2012.11.014","volume":"65","author":"Leyten","year":"2014","journal-title":"Eur Urol"},{"key":"10.4111\/icu.20200395_ref63","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.eururo.2015.04.039","volume":"70","author":"Tomlins","year":"2016","journal-title":"Eur Urol"},{"key":"10.4111\/icu.20200395_ref64","doi-asserted-by":"crossref","first-page":"e19276","DOI":"10.7554\/eLife.19276","volume":"5","author":"Shurtleff","year":"2016","journal-title":"Elife"},{"key":"10.4111\/icu.20200395_ref65","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1038\/sj.bjc.6605058","volume":"100","author":"Nilsson","year":"2009","journal-title":"Br J Cancer"},{"key":"10.4111\/icu.20200395_ref66","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/pcan.2015.40","volume":"18","author":"Donovan","year":"2015","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"10.4111\/icu.20200395_ref67","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1001\/jamaoncol.2016.0097","volume":"2","author":"McKiernan","year":"2016","journal-title":"JAMA Oncol"},{"key":"10.4111\/icu.20200395_ref68","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.eururo.2018.08.019","volume":"74","author":"McKiernan","year":"2018","journal-title":"Eur Urol"},{"key":"10.4111\/icu.20200395_ref69","volume-title":"NCCN Clinical Practice Guidelines in Oncology. Prostate cancer early detection. 2018 Version 2","year":"2018"},{"key":"10.4111\/icu.20200395_ref70","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1158\/1078-0432.CCR-14-3334","volume":"21","author":"Leyten","year":"2015","journal-title":"Clin Cancer Res"},{"key":"10.4111\/icu.20200395_ref71","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.eururo.2016.04.012","volume":"70","author":"Van Neste","year":"2016","journal-title":"Eur Urol"},{"key":"10.4111\/icu.20200395_ref72","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1002\/pros.23401","volume":"77","author":"Hendriks","year":"2017","journal-title":"Prostate"},{"key":"10.4111\/icu.20200395_ref73","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/S0022-5347(05)65652-2","volume":"166","author":"Djavan","year":"2001","journal-title":"J Urol"},{"key":"10.4111\/icu.20200395_ref74","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0022-5347(05)67367-3","volume":"164","author":"Naughton","year":"2000","journal-title":"J Urol"},{"key":"10.4111\/icu.20200395_ref75","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1464-410X.2011.10718.x","volume":"110","author":"Trock","year":"2012","journal-title":"BJU Int"},{"key":"10.4111\/icu.20200395_ref76","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.juro.2012.08.219","volume":"189","author":"Stewart","year":"2013","journal-title":"J Urol"},{"key":"10.4111\/icu.20200395_ref77","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.juro.2014.04.013","volume":"192","author":"Partin","year":"2014","journal-title":"J Urol"},{"key":"10.4111\/icu.20200395_ref78","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/pros.20675","volume":"68","author":"Mehrotra","year":"2008","journal-title":"Prostate"}],"container-title":["Investigative and Clinical Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/icurology.org\/pdf\/10.4111\/icu.20200395","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/icurology.org\/DOIx.php?id=10.4111\/icu.20200395","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/icurology.org\/DOIx.php?id=10.4111\/icu.20200395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T23:25:31Z","timestamp":1609370731000},"score":1,"resource":{"primary":{"URL":"https:\/\/icurology.org\/DOIx.php?id=10.4111\/icu.20200395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":78,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4111\/icu.20200395","relation":{},"ISSN":["2466-0493","2466-054X"],"issn-type":[{"value":"2466-0493","type":"print"},{"value":"2466-054X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"2020-09-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-09","name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-21","name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 The Korean Urological Association, 2021","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}