{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T07:13:27Z","timestamp":1788160407788,"version":"build-2803163510"},"reference-count":27,"publisher":"XMLink","issue":"5","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["icurology.org"],"crossmark-restriction":false},"short-container-title":["Investig Clin Urol"],"published-print":{"date-parts":[[2026]]},"DOI":"10.4111\/icu.20250430","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T04:32:16Z","timestamp":1787545936000},"page":"431","update-policy":"https:\/\/doi.org\/10.4111\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intravesical gemcitabine versus Bacillus Calmette\u2013Gu\u00e9rin (BCG) for intermediate-\/high-risk non\u2013muscle-invasive bladder cancer during the BCG shortage: Safety, efficacy, and health-economic context"],"prefix":"10.4111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2476-5660","authenticated-orcid":false,"given":"Tiago Mestriner","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Medicine, Santa Casa de Sao Paulo School of Medical Sciences, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6627-2549","authenticated-orcid":false,"given":"Giovanni","family":"Demartino","sequence":"additional","affiliation":[{"name":"Department of Urology, Rede D\u2019Or S\u00e3o Luiz, Rio de Janeiro, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2304-9336","authenticated-orcid":false,"given":"Luis Gustavo Morato","family":"de Toledo","sequence":"additional","affiliation":[{"name":"Department of Urology, Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5672-7986","authenticated-orcid":false,"given":"Gabriela Dias","family":"Vetorazzi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Santa Casa de Sao Paulo School of Medical Sciences, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8018-8772","authenticated-orcid":false,"given":"Felipe Falero","family":"Albano","sequence":"additional","affiliation":[{"name":"Department of Urology, Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7912-6979","authenticated-orcid":false,"given":"Vinicius Alves","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Department of Urology, Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4128-1757","authenticated-orcid":false,"given":"Rafael Bali","family":"Moreira","sequence":"additional","affiliation":[{"name":"Department of Urology, Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2533-1610","authenticated-orcid":false,"given":"Roni de Carvalho","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Urology, Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18617","reference":[{"key":"10.4111\/icu.20250430_ref1","first-page":"229","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.4111\/icu.20250430_ref2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.eururo.2021.08.010","volume":"81","author":"Babjuk","year":"2022","journal-title":"Eur Urol"},{"key":"10.4111\/icu.20250430_ref3","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.juro.2016.06.049","volume":"196","author":"Chang","year":"2016","journal-title":"J Urol"},{"key":"10.4111\/icu.20250430_ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00280-016-3003-0","volume":"78","author":"Ciccolini","year":"2016","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.4111\/icu.20250430_ref5","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.3390\/cancers16244125","volume":"16","author":"Matloubieh","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.4111\/icu.20250430_ref6","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/JU.0000000000002740","volume":"208","author":"McElree","year":"2022","journal-title":"J Urol"},{"key":"10.4111\/icu.20250430_ref7","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.juro.2006.10.048","volume":"177","author":"Mariappan","year":"2007","journal-title":"J Urol"},{"key":"10.4111\/icu.20250430_ref8","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1200\/JCO.2008.20.8199","volume":"28","author":"Addeo","year":"2010","journal-title":"J Clin Oncol"},{"issue":"5 Suppl","key":"10.4111\/icu.20250430_ref9","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1200\/JCO.2025.43.5_suppl.717","volume":"43","author":"Bedke","year":"2025","journal-title":"J Clin Oncol"},{"key":"10.4111\/icu.20250430_ref10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3233\/BLC-159001","volume":"1","author":"Lerner","year":"2015","journal-title":"Bladder Cancer"},{"key":"10.4111\/icu.20250430_ref11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.prnil.2025.02.002","volume":"13","author":"Paik","year":"2025","journal-title":"Prostate Int"},{"key":"10.4111\/icu.20250430_ref12","unstructured":"BC Cancer. BC Cancer Protocol Summary GUBGEM [Internet]. BC Cancer. 2019. cited 2024 Nov 2. Available from: https:\/\/www.bccancer.bc.ca\/chemotherapy-protocols-site\/Documents\/Genitourinary\/GUBGEM_Protocol.pdf"},{"key":"10.4111\/icu.20250430_ref13","unstructured":"U.S. Department of Health and Human Services (HHS). Common Terminology Criteria for Adverse Events (CTCAE) version 5.0 [Internet]. HHS. 2017. cited 2024 Sep 15. Available from: https:\/\/dctd.cancer.gov\/research\/ctep-trials\/for-sites\/adverse-events\/ctcae-v5-5x7.pdf"},{"key":"10.4111\/icu.20250430_ref14","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/S0022-5347(05)67707-5","volume":"163","author":"Lamm","year":"2000","journal-title":"J Urol"},{"key":"10.4111\/icu.20250430_ref15","doi-asserted-by":"crossref","first-page":"435","DOI":"10.4111\/icu.20240047","volume":"65","author":"Kim","year":"2024","journal-title":"Investig Clin Urol"},{"key":"10.4111\/icu.20250430_ref16","unstructured":"Centers for Disease Control and Prevention (CDC). Catheter-associated urinary tract infections (CAUTI): summary of recommendations [Internet]. CDC. 2024. cited 2025 Jan 5. Available from: https:\/\/www.cdc.gov\/infection-control\/hcp\/cauti\/summary-of-recommendations.html"},{"key":"10.4111\/icu.20250430_ref17","doi-asserted-by":"crossref","first-page":"302","DOI":"10.4111\/icu.20240362","volume":"66","author":"Kim","year":"2025","journal-title":"Investig Clin Urol"},{"key":"10.4111\/icu.20250430_ref18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3233\/BLC-150008","volume":"1","author":"Steinberg","year":"2015","journal-title":"Bladder Cancer"},{"key":"10.4111\/icu.20250430_ref19","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/S1470-2045(24)00178-5","volume":"25","author":"Necchi","year":"2024","journal-title":"Lancet Oncol"},{"key":"10.4111\/icu.20250430_ref20","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1470-2045(20)30540-4","volume":"22","author":"Boorjian","year":"2021","journal-title":"Lancet Oncol"},{"key":"10.4111\/icu.20250430_ref21","doi-asserted-by":"crossref","first-page":"12596","DOI":"10.3390\/ijms241612596","volume":"24","author":"Claps","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.4111\/icu.20250430_ref22","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.urology.2024.02.033","volume":"187","author":"Huelster","year":"2024","journal-title":"Urology"},{"key":"10.4111\/icu.20250430_ref23","doi-asserted-by":"crossref","first-page":"391.e1","DOI":"10.1016\/j.urolonc.2023.04.005","volume":"41","author":"Bukavina","year":"2023","journal-title":"Urol Oncol"},{"key":"10.4111\/icu.20250430_ref24","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.eururo.2024.12.002","volume":"87","author":"Scilipoti","year":"2025","journal-title":"Eur Urol"},{"key":"10.4111\/icu.20250430_ref25","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.euo.2024.10.012","volume":"8","author":"D\u2019Andrea","year":"2025","journal-title":"Eur Urol Oncol"},{"key":"10.4111\/icu.20250430_ref26","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s41669-022-00325-7","volume":"6","author":"Korkes","year":"2022","journal-title":"Pharmacoecon Open"},{"key":"10.4111\/icu.20250430_ref27","doi-asserted-by":"crossref","first-page":"e213800","DOI":"10.1001\/jamanetworkopen.2021.3800","volume":"4","author":"Williams","year":"2021","journal-title":"JAMA Netw Open"}],"container-title":["Investigative and Clinical Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/icurology.org\/pdf\/10.4111\/icu.20250430","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/icurology.org\/DOIx.php?id=10.4111\/icu.20250430","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/icurology.org\/DOIx.php?id=10.4111\/icu.20250430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:16:03Z","timestamp":1788156963000},"score":1,"resource":{"primary":{"URL":"https:\/\/icurology.org\/DOIx.php?id=10.4111\/icu.20250430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4111\/icu.20250430","relation":{},"ISSN":["2466-0493","2466-054X"],"issn-type":[{"value":"2466-0493","type":"print"},{"value":"2466-054X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"2025-08-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-16","name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 The Korean Urological Association","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}