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Histopathological examination of the resected specimen revealed predominantly undifferentiated pleomorphic sarcoma with sclerosis. Only a small portion of conventional urothelial carcinoma was identified around the urethral diverticulum, which contained glandular epithelium and villous adenoma. The patient showed rapid systemic recurrence and resistance to immune checkpoint inhibitor therapy despite high expression of programmed cell death ligand-1. We report the first case of urethral diverticular carcinoma with sarcomatoid features.<\/jats:p>","DOI":"10.4132\/jptm.2021.04.23","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T01:00:58Z","timestamp":1622509258000},"page":"298-302","update-policy":"https:\/\/doi.org\/10.4132\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sarcomatoid urothelial carcinoma arising in the female urethral diverticulum"],"prefix":"10.4132","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1849-5120","authenticated-orcid":true,"given":"Heae Surng","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2611","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-009-9618-x"},{"key":"ref2","first-page":"703","volume-title":"Urethral diverticulum carcinoma in females: a case series and review of the English and Japanese literature","author":"O\u2019Connor","year":"2018"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-012-0882-5"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(17)35933-5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01626-9"},{"key":"ref6","first-page":"2800","volume-title":"Intradiverticular sarcomatoid carcinoma of the bladder: an overview starting from a peculiar case","author":"Lembo","year":"2016"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-018-1383-9"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1837510"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000355089"},{"key":"ref10","first-page":"92","volume-title":"","author":"Moch","year":"2016"},{"key":"ref11","first-page":"298","volume-title":"","author":"Bostwick","year":"2014"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0085-oa"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)32455-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(17)33297-x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58351-6"}],"container-title":["Journal of Pathology and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jpatholtm.org\/upload\/pdf\/jptm-2021-04-23.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jpatholtm.org\/journal\/view.php?doi=10.4132\/jptm.2021.04.23","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jpatholtm.org\/upload\/pdf\/jptm-2021-04-23.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T05:12:23Z","timestamp":1626325943000},"score":1,"resource":{"primary":{"URL":"http:\/\/jpatholtm.org\/journal\/view.php?doi=10.4132\/jptm.2021.04.23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,15]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"URL":"https:\/\/doi.org\/10.4132\/jptm.2021.04.23","relation":{},"ISSN":["2383-7837","2383-7845"],"issn-type":[{"value":"2383-7837","type":"print"},{"value":"2383-7845","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,15]]},"assertion":[{"value":"2021-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-01","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}