{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:06:21Z","timestamp":1785456381026,"version":"3.56.0"},"reference-count":16,"publisher":"The Korean Society of Pathologists and The Korean Society for Cytopathology","issue":"3","license":[{"start":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T00:00:00Z","timestamp":1643155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["jpatholtm.org"],"crossmark-restriction":true},"short-container-title":["J Pathol Transl Med"],"published-print":{"date-parts":[[2022,5,15]]},"abstract":"<jats:p>Yolk sac tumors (YSTs), which are also called endodermal sinus tumors, are malignant tumors of germ cell origin. These tumors usually occur in the gonads, but 20% of cases have been reported at extragonadal sites. The head and neck is a rarely affected region that accounts for just 1% of all malignant tumors of germ cell origin. In addition, YSTs arise mostly in childhood. We present a rare pathologically pure case of primary adult YST in the sinonasal area. A 45-year-old male patient presented with a rapidly growing mass in the nasal cavity, which caused nasal obstruction and bloody post-nasal drip. The histopathologic features indicated pure YST, and immunohistochemical analysis revealed positive reactivity for Sal-like protein 4 and alpha-fetoprotein. Herein, we discuss the clinical, radiologic, and histologic features of this YST and review other cases of sinonasal YST in adults.<\/jats:p>","DOI":"10.4132\/jptm.2021.12.09","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T05:51:41Z","timestamp":1643089901000},"page":"152-156","update-policy":"https:\/\/doi.org\/10.4132\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A sinonasal yolk sac tumor in an adult"],"prefix":"10.4132","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9940-873X","authenticated-orcid":true,"given":"Jaehoon","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9215-6867","authenticated-orcid":true,"given":"Ji Heui","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7741-7184","authenticated-orcid":true,"given":"Kyeong Cheon","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4911-7774","authenticated-orcid":true,"given":"Kyung-Ja","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2611","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21752"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2195"},{"key":"ref3","first-page":"351","volume-title":"Pure yolk sac tumor of testis in an adult: a rare occurrence","author":"Khan","year":"2014"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03889.x"},{"key":"ref5","first-page":"458","volume-title":"SMARCB1 (INI-1)-deficient sinonasal carcinoma: a series of 39 cases expanding the morphologic and clinicopathologic spectrum of a recently described entity","author":"Agaimy","year":"2017"},{"key":"ref6","first-page":"198","volume-title":"Transitional (cylindric) cell carcinoma with endodermal sinus tumor-like features of the nasopharynx and paranasal sinuses: clinicopathologic and immunohistochemical study of two cases","author":"Manivel","year":"1986"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2007.09.001"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20711"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2010.01.004"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12409"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/1066896917741549"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/rlu.0000000000003265"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0178-9"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/pgp.0000000000000673"},{"key":"ref15","first-page":"29","volume-title":"Congenital teratoma: a clinicopathologic study of 22 fetal and neonatal tumors","author":"Heerema-McKenney","year":"2005"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/pap.0b013e31803240e6"}],"container-title":["Journal of Pathology and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jpatholtm.org\/upload\/pdf\/jptm-2021-12-09.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jpatholtm.org\/journal\/view.php?doi=10.4132\/jptm.2021.12.09","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jpatholtm.org\/upload\/pdf\/jptm-2021-12-09.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T04:03:32Z","timestamp":1652846612000},"score":1,"resource":{"primary":{"URL":"http:\/\/jpatholtm.org\/journal\/view.php?doi=10.4132\/jptm.2021.12.09"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,15]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"URL":"https:\/\/doi.org\/10.4132\/jptm.2021.12.09","relation":{},"ISSN":["2383-7837","2383-7845"],"issn-type":[{"value":"2383-7837","type":"print"},{"value":"2383-7845","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,15]]},"assertion":[{"value":"2021-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-26","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}