{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:56:29Z","timestamp":1792252589472,"version":"4.4.0"},"reference-count":19,"publisher":"The Korean Society of Pathologists and The Korean Society for Cytopathology","issue":"5","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["jpatholtm.org"],"crossmark-restriction":true},"short-container-title":["JPTM"],"published-print":{"date-parts":[[2022,9,15]]},"abstract":"<jats:p>Background: The diagnosis of osteosarcoma (OSA) depends on clinicopathological and radiological correlation. A biopsy is considered the gold standard for OSA diagnosis. However, since OSA is a great histological mimicker, diagnostic challenges exist. Immunohistochemistry (IHC) can serve as an adjunct for the histological diagnosis of OSA. Special AT-rich sequence-binding protein 2 (SATB2) was recently described as a reliable adjunct immunohistochemical marker for the diagnosis of OSA.Methods: We investigated the IHC expression of SATB2 in 95 OSA and 100 non-osteogenic bone and soft tissue tumors using a monoclonal antibody (clone EPNCIR30A). The diagnostic utility of SATB2 and correlation with clinicopathological parameters were analyzed.Results: SATB2 IHC was positive in 88 out of 95 cases (92.6%) of OSA and 50 out of 100 cases (50.0%) of primary non-osteogenic bone and soft tissue tumors. Of the 59 bone tumors, 37 cases (62.7%) were positive for SATB2, and of the 41 soft tissue tumors, 13 cases (31.7%) were positive for SATB2. The sensitivity of SATB2 as a diagnostic test was 92.6%, specificity 50%, positive predictive value 63.8%, and negative predictive value 87.7%.Conclusions: Although SATB2 is a useful diagnostic marker for OSA, other clinical, histological and immunohistochemical features should be considered for the interpretation of SATB2.<\/jats:p>","DOI":"10.4132\/jptm.2022.07.11","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T23:16:07Z","timestamp":1663110967000},"page":"270-280","update-policy":"https:\/\/doi.org\/10.4132\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Special AT-rich sequence-binding protein 2 (SATB2) in the differential diagnosis of osteogenic and non-osteogenic bone and soft tissue tumors"],"prefix":"10.4132","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3387-1841","authenticated-orcid":true,"given":"Sharon","family":"Milton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2893-5812","authenticated-orcid":true,"given":"Anne Jennifer","family":"Prabhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8730-8291","authenticated-orcid":true,"given":"V. T. K.","family":"Titus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5547-5829","authenticated-orcid":true,"given":"Rikki","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9394-7249","authenticated-orcid":true,"given":"Selvamani","family":"Backianathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4494-222X","authenticated-orcid":true,"given":"Vrisha","family":"Madhuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2611","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4103\/2278-330x.187587"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.5958\/2319-5886.2015.00106.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90236-i"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2020.07.017"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2013.280"},{"key":"ref6","volume-title":"","year":"2016"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2010.0503"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/his.12138"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5413.132497"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/his.12911"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.77.s1.05"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2016.06.012"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.110"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-008-0327-z"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1172\/jci112838"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2020.10.025"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/1746-160x-5-22"},{"key":"ref18","first-page":"1920","volume-title":"USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst","author":"Oliveira","year":"2004"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.07.014"}],"container-title":["Journal of Pathology and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/jpatholtm.org\/upload\/pdf\/jptm-2022-07-11.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/jpatholtm.org\/journal\/view.php?doi=10.4132\/jptm.2022.07.11","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/jpatholtm.org\/upload\/pdf\/jptm-2022-07-11.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T05:38:15Z","timestamp":1663652295000},"score":1,"resource":{"primary":{"URL":"http:\/\/jpatholtm.org\/journal\/view.php?doi=10.4132\/jptm.2022.07.11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,15]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"URL":"https:\/\/doi.org\/10.4132\/jptm.2022.07.11","relation":{},"ISSN":["2383-7837","2383-7845"],"issn-type":[{"value":"2383-7837","type":"print"},{"value":"2383-7845","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,15]]},"assertion":[{"value":"2021-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-13","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}