{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:45:13Z","timestamp":1785390313615,"version":"3.55.0"},"reference-count":10,"publisher":"The Korean Society of Pathologists and The Korean Society for Cytopathology","issue":"4","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["jpatholtm.org"],"crossmark-restriction":true},"short-container-title":["J Pathol Transl Med"],"published-print":{"date-parts":[[2023,7,15]]},"abstract":"<jats:p>Intrathyroidal metastasis of tonsillar squamous cell carcinoma is rare. To date, only six cases have been reported in the literature. This case was unusual and presented with thyromegaly before the diagnosis of the primary tumor. A 55-year-old male patient was suspected to have a primary thyroid tumor with nodal metastasis. The thyroid gland was diffusely enlarged, with no discernible mass. Histologically, the thyroid parenchyma revealed extensive endolymphatic tumor emboli, which were positive for p40 and p16 in a background of chronic lymphocytic thyroiditis. Positron emission tomography\u2013computed tomography revealed hypermetabolic activity in the right tonsillar region. Tonsillar biopsy revealed human papillomavirus\u2013positive squamous cell carcinoma. The present case is the first reported case of intrathyroidal metastasis of tonsillar squamous cell carcinoma with an initial clinical presentation of thyroid enlargement before the primary tumor of tonsillar cancer was diagnosed.<\/jats:p>","DOI":"10.4132\/jptm.2023.06.16","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T02:07:12Z","timestamp":1689646032000},"page":"242-245","update-policy":"https:\/\/doi.org\/10.4132\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Intrathyroidal metastasis of tonsillar squamous cell carcinoma masquerading as a primary thyroid tumor"],"prefix":"10.4132","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2105-7837","authenticated-orcid":true,"given":"Jai-Hyang","family":"Go","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2611","reference":[{"key":"ref1","first-page":"e154","volume-title":"Case report: isolated intrathyroid metastasis from undifferentiated and squamous carcinoma of the head and neck: the case for surgery and re-irradiation","author":"Jankowska","year":"2008"},{"key":"ref2","first-page":"428","volume-title":"Thyroid\u2019s metastasis of tonsillar squamous cell carcinoma","author":"Scanelli","year":"2005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.5430\/jst.v7n2p7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.21037\/acr.2018.01.04"},{"key":"ref5","first-page":"62","volume-title":"Two cases of thyroid metastasis from head and neck squamous cell carcinoma detected by FDG-PET\/CT","author":"Aparici","year":"2014"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2018.06.179"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1726305"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25522"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000504651"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-015-0616-2"}],"container-title":["Journal of Pathology and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/jpatholtm.org\/upload\/pdf\/jptm-2023-06-16.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/jpatholtm.org\/journal\/view.php?doi=10.4132\/jptm.2023.06.16","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/jpatholtm.org\/upload\/pdf\/jptm-2023-06-16.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T02:07:51Z","timestamp":1689646071000},"score":1,"resource":{"primary":{"URL":"http:\/\/jpatholtm.org\/journal\/view.php?doi=10.4132\/jptm.2023.06.16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,15]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,7]]}},"URL":"https:\/\/doi.org\/10.4132\/jptm.2023.06.16","relation":{},"ISSN":["2383-7837","2383-7845"],"issn-type":[{"value":"2383-7837","type":"print"},{"value":"2383-7845","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,15]]},"assertion":[{"value":"2023-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-11","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}