{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:53:19Z","timestamp":1777564399535,"version":"3.51.4"},"reference-count":12,"publisher":"The Korean Society of Pathologists and The Korean Society for Cytopathology","issue":"5","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["jpatholtm.org"],"crossmark-restriction":true},"short-container-title":["J Pathol Transl Med"],"published-print":{"date-parts":[[2023,9,15]]},"abstract":"<jats:p>Primary renal myoepithelial carcinoma is an exceedingly rare neoplasm with an aggressive phenotype and Ewing sarcoma breakpoint region 1 (&lt;i&gt;EWSR1&lt;\/i&gt;) rearrangement in a small fraction of cases. In addition to its rarity, the diagnosis can be challenging for the pathologist due to morphologic heterogeneity, particularly on the biopsy specimen. At times, immunohistochemistry may be indecisive; therefore, molecular studies should be undertaken for clinching the diagnosis. We aim to illustrate a case of primary myoepithelial carcinoma of the kidney with &lt;i&gt;EWSR1&lt;\/i&gt;-rearrangement in a 67-year-old male patient who presented with right supraclavicular mass, which was clinically diagnosed as carcinoma of an unknown primary. An elaborate immunohistochemical work-up aided by fluorescent in-situ hybridization allowed us to reach a conclusive diagnosis. This unusual case report advocates that one should be aware of the histological mimickers and begin with broad differential diagnoses alongside sporadic ones and then narrow them down with appropriate ancillary studies.<\/jats:p>","DOI":"10.4132\/jptm.2023.08.08","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T05:56:03Z","timestamp":1695275763000},"page":"284-288","update-policy":"https:\/\/doi.org\/10.4132\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["EWSR1 rearranged primary renal myoepithelial carcinoma: a diagnostic conundrum"],"prefix":"10.4132","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2192-7393","authenticated-orcid":true,"given":"Nilay","family":"Nishith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1766-5012","authenticated-orcid":true,"given":"Zachariah","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2611","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-019-01109-y"},{"key":"ref2","first-page":"105","volume-title":"Primary renal myoepithelial carcinoma with EWSR-1 gene rearrangement: case report and literature review","author":"She","year":"2021"},{"key":"ref3","first-page":"386","volume-title":"Expanding the spectrum of renal tumors in children: primary renal myoepithelial carcinomas with a novel EWSR1-KLF15 fusion","author":"Cajaiba","year":"2016"},{"key":"ref4","first-page":"e17245","volume-title":"A first case report of primary epithelial myoepithelial carcinoma-like renal tumor showing a perivascular pseudorosette-like pattern: description of morphologic, immunohistochemical, and genetic features","author":"Li","year":"2019"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.11.020"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2021200062"},{"key":"ref7","first-page":"1183","volume-title":"Myoepithelial tumors of soft tissue: a clinicopathologic and immunohistochemical study of 101 cases with evaluation of prognostic parameters","author":"Hornick","year":"2003"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20819"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20706"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22216"},{"key":"ref11","first-page":"1337","volume-title":"Mammalian Kruppel-like factors in health and diseases","author":"McConnell","year":"2010"},{"key":"ref12","first-page":"7319","volume-title":"Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Kruppel-like factor, a novel zinc finger repressor","author":"Uchida","year":"2000"}],"container-title":["Journal of Pathology and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/jpatholtm.org\/upload\/pdf\/jptm-2023-08-08.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/jpatholtm.org\/journal\/view.php?doi=10.4132\/jptm.2023.08.08","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/jpatholtm.org\/upload\/pdf\/jptm-2023-08-08.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T05:56:27Z","timestamp":1695275787000},"score":1,"resource":{"primary":{"URL":"http:\/\/jpatholtm.org\/journal\/view.php?doi=10.4132\/jptm.2023.08.08"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,15]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9]]}},"URL":"https:\/\/doi.org\/10.4132\/jptm.2023.08.08","relation":{},"ISSN":["2383-7837","2383-7845"],"issn-type":[{"value":"2383-7837","type":"print"},{"value":"2383-7845","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,15]]},"assertion":[{"value":"2023-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-15","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}