{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T18:00:35Z","timestamp":1775671235976,"version":"3.50.1"},"reference-count":24,"publisher":"The Korean Society of Pathologists and The Korean Society for Cytopathology","issue":"6","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["jpatholtm.org"],"crossmark-restriction":true},"short-container-title":["J Pathol Transl Med"],"published-print":{"date-parts":[[2023,11,15]]},"abstract":"<jats:p>Intravascular lymphoma is characterized by an exclusively intravascular distribution of tumor cells. Intravascular natural killer\/T-cell lymphoma (IVNKTL) is extremely rare, highly aggressive, commonly Epstein-Barr virus (EBV)\u2013positive, and predominantly affects the skin and central nervous system. Here we report a case of IVNKTL diagnosed in a 67-year-old female, presenting with persistent intermittent fever and skin rashes throughout the body. Incisional biopsy of an erythematous lesion on the chest exhibited aggregation of medium to large-sized atypical lymphoid cells confined to the lumen of small vessels that were positive for CD3, granzyme B, and CD56 on immunohistochemistry and EBV-encoded RNA in situ hybridization. EBV DNA was also detected in serum after diagnosis. With a review of 26 cases of IVNKTL to date, we suggest that active biopsy based on EBV DNA detection may facilitate early diagnosis of IVNKTL.<\/jats:p>","DOI":"10.4132\/jptm.2023.10.30","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T01:15:57Z","timestamp":1700442957000},"page":"332-336","update-policy":"https:\/\/doi.org\/10.4132\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Intravascular NK\/T-cell lymphoma: a case report and literature review"],"prefix":"10.4132","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4330-6598","authenticated-orcid":true,"given":"Ji 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