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In this report, we present a case of a 68-year-old woman who had a soft tissue nodule at the posterior calf of her left leg during a physical examination. Pathological examination was performed after complete surgical excision. The patient underwent follow-up for 12 months after surgery without evidence of recurrence or any other complication. This is the first case of intravascular schwannoma reported as a cause of vein obstruction. Microscopically, the tumor was composed of Schwann spindle cells that were immunoreactive for S100 protein and SOX10. This tumor was surrounded by a well-defined vascular smooth muscle wall. Prospective series are required to improve the knowledge on the underlying mechanisms of intravascular schwannoma development.<\/jats:p>","DOI":"10.4132\/jptm.2024.05.15","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T07:21:46Z","timestamp":1719904906000},"page":"249-254","update-policy":"https:\/\/doi.org\/10.4132\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intravascular schwannoma as an extremely unusual cause of vein obstruction: a case report"],"prefix":"10.4132","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7435-3509","authenticated-orcid":true,"given":"Luis Miguel","family":"Chinchilla-T\u00e1bora","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2286-0059","authenticated-orcid":true,"given":"Beatriz 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