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Given the common CD5 co-expression, mantle cell lymphoma (MCL) is one of the most important entities in the differential diagnosis. MCL and CLL\/SLL might exhibit overlapping morphologic and immunohistochemical features, making diagnosis particularly difficult in cases of composite lymphomas. Here, we present a unique case of composite lymphoma in an 86-year-old male, along with a literature review on the immunophenotypic variability of both MCL and CLL, which should always be confirmed with additional ancillary cytogenetic and molecular studies. <\/jats:p>","DOI":"10.4132\/jptm.2025.07.02","type":"journal-article","created":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T22:32:38Z","timestamp":1757284358000},"page":"334-339","update-policy":"https:\/\/doi.org\/10.4132\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Composite chronic lymphocytic leukemia and mantle cell lymphoma involving the bone marrow: a case report and literature 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