{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T11:57:51Z","timestamp":1768391871545,"version":"3.49.0"},"reference-count":20,"publisher":"The Korean Society of Pathologists and The Korean Society for Cytopathology","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["jpatholtm.org"],"crossmark-restriction":true},"short-container-title":["J Pathol Transl Med"],"published-print":{"date-parts":[[2026,1,15]]},"abstract":"<jats:p>Background: Follow-up biopsies in patients with progestin-treated atypical endometrial hyperplasia\/endometrioid intraepithelial neoplasia (AH\/EIN) may show papillary structures, the significance of which is unclear. Methods: The authors reviewed 253 serial specimens of 84 consecutive patients diagnosed with AH\/EIN, inclusive of each patient's pre-progestin treatment sample and all post-treatment specimens. We assessed the predictive relationship between papillary architecture in a post-treatment biopsy and two study outcomes: AH\/EIN or carcinoma in at least one sample subsequent to the one in which papillae were identified, and\/or the last specimen received for that patient. Results: Papillae were identified in only 51.5% of pre-treatment samples but were present in at least one subsequent post-treatment sample for all patients. Post-treatment samples that exhibited papillae and no glandular crowding were associated with AH\/EIN in at least one subsequent specimen in 39.7% (29\/73) of cases, compared to 24.0% (6\/25) in samples with neither papillae nor glandular crowding (p = .227) and 64.0% (16\/25) in samples with concurrent gland crowding and papillae (p = .048). Univariate logistic regression analyses showed that the presence of papillae was not associated with study outcomes (odds ratio [OR], 0.99; 95% confidence interval [CI], 0.49 to 1.99; p = .985), as compared with gland crowding (OR, 1.54; 95% CI, 1.04 to 2.27; p = .031), or concurrent papillae and gland crowding (OR, 2.36; 95% CI, 1.01 to 5.52; p = .048). Conclusions: In post-treatment samples of progestin-treated AH\/EIN, the presence of papillary architecture was not demonstrably associated with study outcomes independent of gland crowding, although the concurrent presence of both features may be significantly predictive.<\/jats:p>","DOI":"10.4132\/jptm.2025.09.12","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:05:31Z","timestamp":1767837931000},"page":"58-68","update-policy":"https:\/\/doi.org\/10.4132\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The significance of papillary architecture in the follow-up biopsies of patients with progestin-treated atypical endometrial hyperplasia"],"prefix":"10.4132","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9538-9535","authenticated-orcid":true,"given":"Wangpan J.","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8017-2854","authenticated-orcid":true,"given":"Oluwole","family":"Fadare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2611","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.1315"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16050914"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000004989"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232231"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/01443610802355817"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31825dd4ff"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21650"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000005297"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2016.27.e8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2014.25.3.164"},{"key":"ref11","first-page":"1","volume-title":"","author":"Zheng","year":"2024"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/pgp.0000000000000791"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/his.13994"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2021.10.001"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/pas.0b013e31802d68ce"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1309\/ajcpm2tsddf1mhbz"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.4.305"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1177\/1066896906299120"},{"key":"ref19","first-page":"250","volume-title":"","author":"Lax","year":"2020"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.11.033"}],"container-title":["Journal of Pathology and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/jpatholtm.org\/upload\/pdf\/jptm-2025-09-12.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/jpatholtm.org\/journal\/view.php?doi=10.4132\/jptm.2025.09.12","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/jpatholtm.org\/upload\/pdf\/jptm-2025-09-12.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T07:09:40Z","timestamp":1768374580000},"score":1,"resource":{"primary":{"URL":"http:\/\/jpatholtm.org\/journal\/view.php?doi=10.4132\/jptm.2025.09.12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,15]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"URL":"https:\/\/doi.org\/10.4132\/jptm.2025.09.12","relation":{},"ISSN":["2383-7837","2383-7845"],"issn-type":[{"value":"2383-7837","type":"print"},{"value":"2383-7845","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,15]]},"assertion":[{"value":"2025-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-08","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}