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Methods: Thirty-four surgically resected pT1 CRCs were reevaluated for 2-dimensional (2D) VI using hematoxylin and eosin (H&amp;E)\u2013stained slides with additional elastic and desmin immunohistochemical staining (cohort A). Additionally, 27 pT1 CRCs without knowing VI status were selected for 3-dimensional (3D) VI evaluation only (cohort B). All 61 cases (cohorts A and B) were studied in 3D using tissue clearing. Results: VI was detected more commonly in 3D (17\/34, 50.0%) than in 2D H&amp;E slide evaluation (9\/34, 26.5%, p = .047). When VI was identified in 3D (27\/61, 44.3%), the most common phase was that of intraluminal growth (22\/27, 81.5%), followed by intravasation (7\/27, 25.9%) and extravasation (5\/27, 18.5%). E-cadherin expression was characterized in 3D in foci of VI and varied in each phase of invasion. Conclusions: All three phases were observed in VI of pT1 CRCs. The extravasation of neoplastic cells from foci of VI in pT1 CRC suggests that VI could be a route of intratumoral spreading in a subset of pT1 CRCs.<\/jats:p>","DOI":"10.4132\/jptm.2025.12.19","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:18:07Z","timestamp":1773101887000},"page":"246-262","update-policy":"https:\/\/doi.org\/10.4132\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["3-Dimensional reconstruction reveals frequent intraluminal growth of submucosal veins in surgically resected pT1 colorectal 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