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The linear response was obtained over the concentration range from 10 to 2000 ng\/mL for MDN and EDDP. The absolute recoveries of MDN and EDDP were 95.9%-98.9% and 94.8%-102.4%, with relative standard deviation (RSD) ranging from 1.8% to 2.7% and 1.8% to 3.9%, respectively. The intra- and interday precisions were found to be less than 5% for both analytes. The limits of detection of MDN and EDDP were 4 and 5 ng\/mL, respectively. The presented method was convenient for therapeutic drug monitoring and pharmacokinetic studies in patients on heroin-assisted MDN therapy. <\/jats:p>","DOI":"10.4137\/aci.s25554","type":"journal-article","created":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T22:46:28Z","timestamp":1440629188000},"page":"ACI.S25554","update-policy":"http:\/\/dx.doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Determination and Validation of a Solid-phase Extraction Gas Chromatography-mass Spectrometry for the Quantification of Methadone and Its Principal Metabolite in Human Plasma"],"prefix":"10.4137","volume":"10","author":[{"given":"Fouad","family":"Chiadmi","sequence":"first","affiliation":[{"name":"Department of Forensic Laboratory, Jean Verdier Hospital\u2013-APHP, University Hospitals of Paris Seine Saint-Denis, Bondy, 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