{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:51:45Z","timestamp":1767984705711,"version":"3.49.0"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Anal Chem\ufffdInsights"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p> Two stability indicating chromatographic methods were proposed for the determination of almotriptan, eletriptan, and rizatriptan, in presence of their acid degradation products. The first method is a quantitative densitometric thin layer chromatography. The developing systems were; acetonitrile: methanol: dichloromethane: ammonia (10:6:3:1 v\/v), ethyl acetate: methanol: ammonia (15:4:1 v\/v), and methanol: acetonitrile: ammonia (9:4:1 v\/v) for almotriptan, eletriptan and rizatriptan respectively. The TLC plates were scanned at 235 nm. Linear relationships were obtained over concentration ranges (5-50 \u03bcg\/spot) for almotriptan and rizatriptan, and (5-60 \u03bcg\/spot) for eletriptan. The second method based on the separation and determination of the studied drugs, using RP-HPLC technique. The separation was achieved on C18 Hypersil column, elution was carried out using phosphate buffer pH 3: methanol: acetonitrile (2: 1:1 v\/v) at flow rate 2 mL\/min and UV detection at 235 nm. Linear relationships were obtained over concentration ranges (10-200 \u03bcg\/mL) for almotriptan and eletriptan, and (10-180 \u03bcg\/mL) for rizatriptan. The chromatographic methods were successfully applied for the determination of each of the studied drugs in pure form, tablet form, and in laboratory prepared mixtures with their acid degradation products. <\/jats:p>","DOI":"10.4137\/aci.s8864","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T21:38:55Z","timestamp":1337031535000},"page":"ACI.S8864","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Two chromatographic Methods for the Determination of some Antimigraine Drugs"],"prefix":"10.4137","volume":"7","author":[{"given":"Ramzia I.","family":"El-Bagary","sequence":"first","affiliation":[{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nashwah G.","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Princess Noura Bint Abdelrahman University, Riyadh, Saudi Arabia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba A.","family":"Nasr","sequence":"additional","affiliation":[{"name":"National Organization for Drug Control and Research, Giza, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,5,14]]},"reference":[{"key":"bibr1-ACI.S8864","volume-title":"Martindale, The complete drug reference","author":"Sweetman Sean C","year":"2005","edition":"34"},{"key":"bibr2-ACI.S8864","volume-title":"The Merck Index","year":"2006"},{"key":"bibr3-ACI.S8864","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2007.11.029"},{"key":"bibr4-ACI.S8864","volume-title":"Manufacture procedure obtained from European Egyptian Pharm."},{"key":"bibr5-ACI.S8864","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-008-0673-8"},{"key":"bibr6-ACI.S8864","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(99)00199-5"},{"key":"bibr9-ACI.S8864","doi-asserted-by":"publisher","DOI":"10.1080\/10826079808001250"},{"key":"bibr10-ACI.S8864","doi-asserted-by":"publisher","DOI":"10.1080\/00032710701575959"},{"issue":"1","key":"bibr11-ACI.S8864","first-page":"7","volume":"26","author":"Qin Y.P.","year":"2003","journal-title":"Fenxi Zazhi."},{"key":"bibr12-ACI.S8864","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2004.02.021"},{"key":"bibr13-ACI.S8864","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.07.027"},{"key":"bibr14-ACI.S8864","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0231(20000215)14:3<168::AID-RCM861>3.0.CO;2-9"},{"key":"bibr15-ACI.S8864","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.528"},{"key":"bibr16-ACI.S8864","doi-asserted-by":"publisher","DOI":"10.1002\/1615-9314(20010901)24:9<784::AID-JSSC784>3.0.CO;2-2"},{"key":"bibr18-ACI.S8864","volume-title":"British Pharmacopoeia","year":"1965"}],"container-title":["Analytical Chemistry Insights"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.4137\/ACI.S8864","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.4137\/ACI.S8864","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.4137\/ACI.S8864","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T03:53:32Z","timestamp":1609818812000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.4137\/ACI.S8864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":15,"alternative-id":["10.4137\/ACI.S8864"],"URL":"https:\/\/doi.org\/10.4137\/aci.s8864","relation":{},"ISSN":["1177-3901","1177-3901"],"issn-type":[{"value":"1177-3901","type":"print"},{"value":"1177-3901","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}