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Domestication has led to a series of remarkable changes in a variety of plants and animals, in what is termed the \u201cdomestication phenotype.\u201d In domesticated animals, this general phenotype typically consists of similar changes in tameness, behavior, size\/morphology, color, brain composition, and adrenal gland size. This domestication phenotype is seen in a range of different animals. However, the genetic basis of these associated changes is still puzzling. The genes for these different traits tend to be grouped together in clusters in the genome, though it is still not clear whether these clusters represent pleiotropic effects, or are in fact linked clusters. This review focuses on what is currently known about the genetic architecture of domesticated animal species, if genes of large effect (often referred to as major genes) are prevalent in driving the domestication phenotype, and whether pleiotropy can explain the loci underpinning these diverse traits being colocated.<\/jats:p>","DOI":"10.4137\/bbi.s28902","type":"journal-article","created":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T16:43:27Z","timestamp":1444668207000},"page":"BBI.S28902","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Article Commentary: The Genetic Architecture of Domestication in Animals"],"prefix":"10.4137","volume":"9S4","author":[{"given":"Dominic","family":"Wright","sequence":"first","affiliation":[{"name":"IFM Biology, AVIAN Behavioural Genomics and Physiology Group, Linkoping University, Linkoping, 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