{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:26:16Z","timestamp":1790706376944,"version":"4.1.0"},"reference-count":44,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Bioinform Biol Insights"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>Acute cardiac allograft rejection is a serious complication of heart transplantation. Investigating molecular processes in whole blood via microarrays is a promising avenue of research in transplantation, particularly due to the non-invasive nature of blood sampling. However, whole blood is a complex tissue and the consequent heterogeneity in composition amongst samples is ignored in traditional microarray analysis. This complicates the biological interpretation of microarray data. Here we have applied a statistical deconvolution approach, cell-specific significance analysis of microarrays (csSAM), to whole blood samples from subjects either undergoing acute heart allograft rejection (AR) or not (NR). We identified eight differentially expressed probe-sets significantly correlated to monocytes (mapping to 6 genes, all down-regulated in ARs versus NRs) at a false discovery rate (FDR) \u2264 15%. None of the genes identified are present in a biomarker panel of acute heart rejection previously published by our group and discovered in the same data.<\/jats:p>","DOI":"10.4137\/bbi.s9197","type":"journal-article","created":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T17:20:08Z","timestamp":1334078408000},"page":"BBI.S9197","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["White Blood Cell Differentials Enrich Whole Blood Expression Data in the Context of Acute Cardiac Allograft Rejection"],"prefix":"10.4137","volume":"6","author":[{"given":"Casey P.","family":"Shannon","sequence":"first","affiliation":[{"name":"NCE CECR PROOF Centre of Excellence, Vancouver, BC, Canada."},{"name":"UBC James Hogg Research Centre and Institute of Heart + Lung Health, Vancouver, BC, 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