{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:36:36Z","timestamp":1775806596873,"version":"3.50.1"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biomark\ufffdCancer"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p> In order to develop a new tool for diagnosis of breast cancer based on autoantibodies against a panel of biomarkers, a clinical trial including blood samples from 507 subjects was conducted. All subjects showed a breast abnormality on exam or breast imaging and final biopsy pathology of either breast cancer patients or healthy controls. Using an enzyme-linked immunosorbent assay, the samples were tested for autoantibodies against a predetermined number of biomarkers in various models that were used to determine a diagnosis, which was compared to the clinical status. Our new assay achieved a sensitivity of 95.2% [CI = 92.8\u201396.8%] at a fixed specificity of 49.5%. Receiver-operator characteristic curve analysis showed an area under the curve of 80.1% [CI = 72.6\u201387.6%]. These results suggest that a blood test which is based on models comprising several autoantibodies to specific biomarkers may be a new and novel tool for improving the diagnostic evaluation of breast cancer. <\/jats:p>","DOI":"10.4137\/bic.s13236","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T20:27:58Z","timestamp":1384892878000},"page":"BIC.S13236","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["An Antibody-based Blood Test Utilizing a Panel of Biomarkers as a New Method for Improved Breast Cancer Diagnosis"],"prefix":"10.4137","volume":"5","author":[{"given":"Galit","family":"Yahalom","sequence":"first","affiliation":[{"name":"Eventus Diagnostics (Israel) Ltd., Ora, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daria","family":"Weiss","sequence":"additional","affiliation":[{"name":"University of Texas, MD Anderson Cancer Center, Houston, TX, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilya","family":"Novikov","sequence":"additional","affiliation":[{"name":"Eventus Diagnostics (Israel) Ltd., Ora, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Therese B.","family":"Bevers","sequence":"additional","affiliation":[{"name":"University of Texas, MD Anderson Cancer Center, Houston, TX, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laszlo G.","family":"Radvanyi","sequence":"additional","affiliation":[{"name":"University of Texas, MD Anderson Cancer Center, Houston, TX, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Liu","sequence":"additional","affiliation":[{"name":"University of Texas, MD Anderson Cancer Center, Houston, TX, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Piura","sequence":"additional","affiliation":[{"name":"Eventus Diagnostics (Israel) Ltd., Ora, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Iacobelli","sequence":"additional","affiliation":[{"name":"Media Pharma Srl, Chieti, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria T.","family":"Sandri","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Division, Istituto Europeo di Oncologia, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Cassano","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Division, Istituto Europeo di Oncologia, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanir M.","family":"Allweis","sequence":"additional","affiliation":[{"name":"Kaplan Medical Center, Rehovot, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arie","family":"Bitterman","sequence":"additional","affiliation":[{"name":"Carmel Medical Center, Surgery A, Haifa, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pnina","family":"Engelman","sequence":"additional","affiliation":[{"name":"Zvulun Breast Center, Clalit Organization, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis M.","family":"Vence","sequence":"additional","affiliation":[{"name":"University of Texas, MD Anderson Cancer Center, Houston, TX, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marvin M.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Eventus Diagnostics Inc. 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