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Although abnormalities of the FADD\/death receptor apoptotic pathways have been established in tumorigenesis, fewer studies have analyzed the expression and role of phosphorylated FADD (pFADD). Our identification of FADD as a lymphoma-associated autoantigen in T-cell lymphoma patients raises the possibility that pFADD, with its correlation with cell cycle, may possess role(s) in human T-cell lymphoma development. This immunohistochemical study investigated pFADD protein expression in a range of normal tissues and lymphomas, particularly T-cell lymphomas that require improved therapies. Whereas pFADD was expressed only in scattered normal T cells, it was detected at high levels in T-cell lymphomas (eg, 84% anaplastic large cell lymphoma and 65% peripheral T cell lymphomas, not otherwise specified). The increased expression of pFADD supports further study of its clinical relevance and role in lymphomagenesis, highlighting phosphorylation of FADD as a potential therapeutic target.<\/jats:p>","DOI":"10.4137\/bmi.s16553","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T20:14:50Z","timestamp":1409688890000},"page":"BMI.S16553","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Increased Expression of Phosphorylated FADD in Anaplastic Large Cell and Other T-Cell Lymphomas"],"prefix":"10.4137","volume":"9","author":[{"given":"Suketu","family":"Patel","sequence":"first","affiliation":[{"name":"Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Murphy","sequence":"additional","affiliation":[{"name":"Center for 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