{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:23:52Z","timestamp":1777465432493,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biomark\ufffdInsights"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>\n                    Interstitial lung disease (ILD) is frequently associated with collagen disease. It is then designated as collagen vascular disease-associated ILD (CVD-ILD), and influences patients\u2019 prognosis. The prognosis of acute-onset diffuse ILD (AoDILD) occurring in patients with collagen disease is quite poor. Here, we report our investigation of auto-antibody (Ab) profiles to determine whether they maybe useful in diagnosing CVD-ILD or AoDILD in collagen disease. Auto-Ab profiles were analyzed using the Lambda Array Beads Multi-Analyte System, granulocyte immunofluorescence test, ProtoArray Human Protein Microarray, AlphaScreen assay, and glutathione S-transferase capture enzyme-linked immunosorbent assay in 34 patients with rheumatoid arthritis (RA) with or without CVD-ILD and in 15 patients with collagen disease with AoDILD. The average anti-major histocompatibility complex class I-related chain A (MICA) Ab levels were higher in RA patients with CVD-ILD than in those without (P = 0.0013). The ratio of the average anti-MICA Ab level to the average anti-human leukocyte antigen class I Ab level (ie, MICA\/Class I) was significantly higher in RA patients with CVD-ILD compared with those without (P = 4.47 \u00d7 10\n                    <jats:sup>\u20135<\/jats:sup>\n                    ). To the best of our knowledge, this is the first report of auto-Ab profiles in CVD-ILD. The MICA\/ Class I ratio could be a better marker for diagnosing CVD-ILD than KL-6 (Krebs von den lungen-6).\n                  <\/jats:p>","DOI":"10.4137\/bmi.s28209","type":"journal-article","created":{"date-parts":[[2015,8,16]],"date-time":"2015-08-16T20:44:57Z","timestamp":1439757897000},"page":"BMI.S28209","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class l-Related Chain a (MICA) as Markers of ILD"],"prefix":"10.4137","volume":"10","author":[{"given":"Hiroshi","family":"Furukawa","sequence":"first","affiliation":[{"name":"Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan."},{"name":"Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shomi","family":"Oka","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan."},{"name":"Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Fuchu, Japan."},{"name":"Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Fuchu, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoe","family":"Masuo","sequence":"additional","affiliation":[{"name":"Technical Marketing Department, VERITAS Corporation, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiaki","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Research and Development Department Central Blood Institute, Japanese Red Cross Society, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunichi","family":"Funano","sequence":"additional","affiliation":[{"name":"Proteo-Medicine Research Center, Ehime University, Toon."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"lntergated Center for Science, Ehime University, Toon."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Komiya","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoshi","family":"Fukui","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Sawasaki","sequence":"additional","affiliation":[{"name":"Cell-Free Science and Technology Research Center, Ehime University, Matsuyama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Tadokoro","sequence":"additional","affiliation":[{"name":"Research and Development Department Central Blood Institute, Japanese Red Cross Society, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Nose","sequence":"additional","affiliation":[{"name":"Research and Development Department Central Blood Institute, Japanese Red Cross Society, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeto","family":"Tohma","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,8,16]]},"reference":[{"key":"bibr1-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1080\/030097400447552"},{"key":"bibr2-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq035"},{"key":"bibr3-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.4508"},{"key":"bibr4-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-14-9"},{"key":"bibr5-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.3.2107134"},{"key":"bibr6-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.4172\/1745-7580.1000064"},{"key":"bibr7-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.07.006"},{"key":"bibr8-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker518"},{"key":"bibr9-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060442"},{"key":"bibr10-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1002\/art.24621"},{"issue":"5","key":"bibr11-BMI.S28209","first-page":"1012","volume":"34","author":"Matsushita T.","year":"2007","journal-title":"\/Rheumatol."},{"key":"bibr12-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2929"},{"key":"bibr13-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033133"},{"key":"bibr14-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"bibr15-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"bibr16-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"bibr17-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02779.x"},{"key":"bibr18-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1977.tb00994.x"},{"key":"bibr19-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M800596-MCP200"},{"key":"bibr20-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1021\/cc9900706"},{"key":"bibr21-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1021\/pr9010553"},{"key":"bibr22-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.2.559"},{"key":"bibr23-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.232580399"},{"issue":"3","key":"bibr24-BMI.S28209","first-page":"199","volume":"220","author":"Tanaka Y.","year":"2010","journal-title":"TohokuJExp Med."},{"key":"bibr25-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2006-449"},{"key":"bibr26-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1949.02900430001001"},{"key":"bibr27-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1186\/ar4255"},{"key":"bibr28-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-012-8347-x"},{"key":"bibr29-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2014.03.024"},{"key":"bibr30-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.09.006"},{"key":"bibr31-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-711-2_14"},{"key":"bibr32-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.096917"},{"key":"bibr33-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199103000-00011"},{"key":"bibr34-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e3283342780"},{"issue":"6","key":"bibr35-BMI.S28209","first-page":"455","volume":"37","author":"Yabe T.","year":"1993","journal-title":"Immunogenetks."},{"issue":"8","key":"bibr36-BMI.S28209","first-page":"8","volume":"13","author":"Spear P.","year":"2013","journal-title":"CancerImmun."},{"key":"bibr37-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.5.2578-2586.2006"},{"key":"bibr38-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.8.5481"},{"key":"bibr39-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.032668099"},{"key":"bibr40-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200535290"},{"key":"bibr41-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(03)00038-7"},{"key":"bibr42-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.07.024"},{"key":"bibr43-BMI.S28209","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067160"}],"container-title":["Biomarker Insights"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.4137\/BMI.S28209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.4137\/BMI.S28209","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.4137\/BMI.S28209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:25:43Z","timestamp":1777382743000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.4137\/BMI.S28209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":43,"alternative-id":["10.4137\/BMI.S28209"],"URL":"https:\/\/doi.org\/10.4137\/bmi.s28209","relation":{},"ISSN":["1177-2719","1177-2719"],"issn-type":[{"value":"1177-2719","type":"print"},{"value":"1177-2719","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]}}}