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Both, the adenoma-carcinoma and the inflammation-carcinogenesis processes are characterized by active angiogenesis. Recent studies also have shown that anti-angiogenesis might be a novel therapeutic approach for IBD. Thrombospondin 1 (TSP1) is an extracellular protein well known for its anti-angiogenic properties. TSP1 also has key functions in inflammation, which is assumed to be the primary cause for carcinogenesis in IBD. This review is focused on the role of TSP1 in colorectal carcinogenesis. The therapeutic effects of TSP derived-peptides on inhibiting the inflammation-carcinogenesis progression are also discussed.<\/jats:p>","DOI":"10.4137\/bmi.s630","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T05:05:31Z","timestamp":1510117531000},"page":"BMI.S630","source":"Crossref","is-referenced-by-count":16,"title":["The Role of Thrombospondin 1 on Intestinal Inflammation and Carcinogenesis"],"prefix":"10.4137","volume":"3","author":[{"given":"Linda S.","family":"Gutierrez","sequence":"first","affiliation":[{"name":"Wilkes University, Wilkes-Barre, Pennsylvania U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,3,28]]},"reference":[{"key":"bibr1-BMI.S630","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1046"},{"key":"bibr2-BMI.S630","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/24.3.353"},{"issue":"1","key":"bibr3-BMI.S630","first-page":"78","volume":"36","author":"Steele V.E.","year":"2003","journal-title":"J. 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