{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:56:52Z","timestamp":1777694212461,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Sertoli-Leydig cell tumors (SLCTs) are rare tumors mostly occurring in young women. Here we report an unusual case of a SLCT with simultaneous occurrence of endometrioid adenocarcinoma of the endometrium in a woman in menopause.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>A 67-year-old woman presented with progressive signs of virilization. Blood tests showed increased levels of testosterone, delta-4-androstenedione, and dehydroepiandrosterone (DHEA). DHEA-sulphate, 17\u03b2-estradiol, estrone, and sex-hormone binding globulin serum levels were within the normal range. Magnetic resonance imaging revealed a solid mass of 2.7 \u00d7 2.9 cm in the right ovary set against the background of the uterus. The patient underwent bilateral salpingo-oophoretomy with hysterectomy. The mass in the right ovary was a differentiated SLCT. Incidentally, the endometrium revealed an endometrioid adenocacinoma. Following surgical treatment the plasma androgens dropped to normal levels, and signs and symptoms of virilization improved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SLCT should be suspected in postmenopausal women who present rapid progressive androgen excess symptoms with hyperandrogenemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4137\/ccrep.s10555","type":"journal-article","created":{"date-parts":[[2012,10,30]],"date-time":"2012-10-30T16:55:59Z","timestamp":1351616159000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Virilizing Leydig-Sertoli Cell Ovarian Tumor Associated with Endometrioid Carcinoma of the Endometrium in a Postmenopausal Patient: Case Report and General Considerations"],"prefix":"10.4137","volume":"5","author":[{"given":"Paola","family":"Di Giacinto","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of System Medicine, Section of Reproductive Endocrinology University of TorVergata, Fatebenefratelli Hospital (San Giovanni Calibita), Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Chioma","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of System Medicine, Section of Reproductive Endocrinology University of TorVergata, Fatebenefratelli Hospital (San Giovanni Calibita), Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Vancieri","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of System Medicine, Section of Reproductive Endocrinology University of TorVergata, Fatebenefratelli Hospital (San Giovanni Calibita), Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Guccione","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of System Medicine, Section of Reproductive Endocrinology University of TorVergata, Fatebenefratelli Hospital (San Giovanni Calibita), Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Cicerone","sequence":"additional","affiliation":[{"name":"Department of Pathology, Section of Histopathology Fatebenefratelli Hospital (San Giovanni Calibita), Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Ulisse","sequence":"additional","affiliation":[{"name":"Department of experimental Medicine, Section of Medical Physiopathology and Endocrinology, Sapienza University of Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Mariani","sequence":"additional","affiliation":[{"name":"Department of experimental Medicine, Section of Medical Physiopathology and Endocrinology, Sapienza University of Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camillo","family":"Autore","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Clinical and Molecular Medicine, Sapienza University of Rome, Sant'Andrea Hospital, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Fabbri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Endocrinology Unit, St. Eugenio and Centro Traumatologico Ortopedico A. Alesini Hospitals, University of Rome Tor Vergata, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucio","family":"Gnessi","sequence":"additional","affiliation":[{"name":"Department of experimental Medicine, Section of Medical Physiopathology and Endocrinology, Sapienza University of Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costanzo","family":"Moretti","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of System Medicine, Section of Reproductive Endocrinology University of TorVergata, Fatebenefratelli Hospital (San Giovanni Calibita), Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,10,30]]},"reference":[{"key":"bibr1-CCRep.S10555","first-page":"146","volume-title":"World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of the Breast and Female Genital Organs.","author":"Tavassoli F.A.","year":"2003"},{"key":"bibr2-CCRep.S10555","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198508000-00001"},{"key":"bibr3-CCRep.S10555","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3182146e42"},{"key":"bibr4-CCRep.S10555","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-009-0321-x"},{"key":"bibr5-CCRep.S10555","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.06.011"},{"key":"bibr6-CCRep.S10555","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-21-11-1440"},{"key":"bibr7-CCRep.S10555","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908123410706"},{"key":"bibr8-CCRep.S10555","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.21.4.0404"},{"key":"bibr9-CCRep.S10555","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1986"},{"issue":"6","key":"bibr10-CCRep.S10555","first-page":"921","volume":"74","author":"Koonings P.P.","year":"1989","journal-title":"Obstet Gynecol."},{"key":"bibr11-CCRep.S10555","doi-asserted-by":"publisher","DOI":"10.1007\/BF02215988"},{"key":"bibr12-CCRep.S10555","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2010.085951"},{"key":"bibr13-CCRep.S10555","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2008.11.010"},{"key":"bibr14-CCRep.S10555","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10394"},{"key":"bibr15-CCRep.S10555","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh075"},{"key":"bibr16-CCRep.S10555","doi-asserted-by":"publisher","DOI":"10.1038\/34432"},{"key":"bibr17-CCRep.S10555","doi-asserted-by":"publisher","DOI":"10.1038\/ng0198-38"},{"key":"bibr18-CCRep.S10555","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.198499"},{"key":"bibr19-CCRep.S10555","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64735-9"},{"issue":"4","key":"bibr20-CCRep.S10555","first-page":"452","volume":"32","author":"Kondi-Pafiti A.","year":"2011","journal-title":"Eur J Gynaecol Oncol."},{"key":"bibr21-CCRep.S10555","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-5014"},{"key":"bibr22-CCRep.S10555","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-07-0064"},{"key":"bibr23-CCRep.S10555","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.73322"}],"container-title":["Clinical Medicine Insights: Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4137\/CCRep.S10555","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4137\/CCRep.S10555","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4137\/CCRep.S10555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:14:41Z","timestamp":1777454081000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4137\/CCRep.S10555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":23,"alternative-id":["10.4137\/CCRep.S10555"],"URL":"https:\/\/doi.org\/10.4137\/ccrep.s10555","relation":{},"ISSN":["1179-5476","1179-5476"],"issn-type":[{"value":"1179-5476","type":"print"},{"value":"1179-5476","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1]]},"article-number":"CCRep.S10555"}}