{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:18:36Z","timestamp":1788157116666,"version":"build-2803163510"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Smoking is a major risk factor for a variety of diseases. Electronic cigarettes are battery-operated devices that deliver nicotine to the lungs by evaporation of a liquid. Chronic idiopathic neutrophilia is a condition characterized by elevated white blood cell and neutrophil counts without any underlying disease; smoking has been implicated as a potential cause.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A male Caucasian patient, born in 1977, presented in September 2005 with asymptomatic elevation of white blood cell and neutrophil count, and mildly-elevated C-reactive protein levels. He was a smoker since 1996 and was treated with 20 mg\/day of simvastatin since 2003 due to hyperlipidemia. Clinical examination, and laboratory and imaging investigations ruled out any infectious, haematological, rheumatological, or endocrine conditions. He was followed-up regularly and was advised to stop smoking. He had 2 unsuccessful attempts to quit smoking; one was unassisted and the second was performed with the use of both varenicline and nicotine replacement therapy (patches). During the subsequent 6.5 years, his leukocyte and C-reactive protein levels were repeatedly elevated; the condition was consistent with chronic idiopathic neutrophilia. In February 2012, he started using electronic cigarettes and he managed to quit smoking within 10 days. After 6 months, laboratory examination showed normalized leukocyte count and C-reactive protein levels, confirmed immediately by a second laboratory and by repeated tests after 1 and 2 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Smoking cessation with the use of electronic cigarette led to reversal of chronic idiopathic neutrophilia. The daily use of electronic cigarette may help preserve the beneficial effects of smoking cessation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4137\/ccrep.s11175","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T20:16:32Z","timestamp":1359058592000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Chronic Idiopathic Neutrophilia in A Smoker, Relieved after Smoking Cessation with the Use of Electronic Cigarette: A Case Report"],"prefix":"10.4137","volume":"6","author":[{"given":"Konstantinos E.","family":"Farsalinos","sequence":"first","affiliation":[{"name":"Onassis Cardiac Surgery Center, Kallithea, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Romagna","sequence":"additional","affiliation":[{"name":"Abich s.r.l. Toxicological Laboratory, Verbania, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,1,24]]},"reference":[{"key":"bibr1-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjr.0000214609.06738.62"},{"key":"bibr2-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38142.554479.AE"},{"key":"bibr3-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.1136\/tc.2006.016246"},{"key":"bibr4-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.4.1089"},{"key":"bibr5-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.92.6.990"},{"key":"bibr6-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2004.00540.x"},{"key":"bibr7-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.869008"},{"key":"bibr8-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7517-3-37"},{"key":"bibr9-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e31821ec7cc"},{"key":"bibr10-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)80071-5"},{"key":"bibr11-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197406062902302"},{"key":"bibr12-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.09.002"},{"key":"bibr13-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2011.300526"},{"key":"bibr14-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.1057\/jphp.2010.41"},{"key":"bibr15-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-786"},{"key":"bibr16-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2010.12.006"},{"key":"bibr17-CCRep.S11175","unstructured":"RomagnaG., AllifranchiniE., BocchietoE., TodeshiS., EspositoM., FarsalinosK. Cytotoxicity of electronic cigarette vapor extract on cultured mammalian fibroblasts (ClearStream-Life project): comparison with tobacco smoke extract [abstract]. [http:\/\/www.srnteurope.org\/assets\/Abstract-Book-Final.pdf.] Poster RRP17. 14th Annual Meeting of the Society for Research on Nicotine and Tobacco, Helsinki; 2012 (Accessed Nov 2012)."},{"key":"bibr18-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2443"},{"key":"bibr19-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.07.025"},{"key":"bibr20-CCRep.S11175","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/eurheartj\/ehr292","volume":"33","author":"Farsalinos K.","year":"2012","journal-title":"Eur Heart J."},{"key":"bibr21-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-011-0308-7"},{"key":"bibr22-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.12.047"},{"key":"bibr23-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.10.2167"},{"key":"bibr24-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704033361401"},{"key":"bibr25-CCRep.S11175","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0020160"}],"container-title":["Clinical Medicine Insights: Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4137\/CCRep.S11175","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4137\/CCRep.S11175","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4137\/CCRep.S11175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:14:47Z","timestamp":1777454087000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4137\/CCRep.S11175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":25,"alternative-id":["10.4137\/CCRep.S11175"],"URL":"https:\/\/doi.org\/10.4137\/ccrep.s11175","relation":{},"ISSN":["1179-5476","1179-5476"],"issn-type":[{"value":"1179-5476","type":"print"},{"value":"1179-5476","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1]]},"article-number":"CCRep.S11175"}}