{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:58:38Z","timestamp":1777694318271,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Lymphomas with recurrent chromosomal breakpoints activating multiple oncogenes, including MYC, BCL2, and BCL6 are often referred to as \u201cDual Hit\u201d or \u201cDouble Hit\u201d lymphomas (DHL). In the updated classification for malignant lymphomas by the World Health Organization (WHO), the novel category of \u201cB-cell lymphoma unclassifiable with features intermediate between diffuse large B-cell lymphoma (DLBCL) and Burkitt's lymphoma (BL)\u201d was proposed in an attempt to create a (temporary) container for aggressive mature B-cell lymphomas that should not be diagnosed as either BL or DLBCL. DHL make up an important part of this novel WHO category, the other part representing heterogeneous cases of aggressive B-cell lymphoma that have features of BL. DHL are highly aggressive lymphomas with generally poor response to first line and salvage treatment. Limited data is available to guide therapeutic decisions, and despite aggressive measures including high dose (HD) chemotherapy followed by autologous hematopoietic cell transplantation (AHCT), outcome is unsatisfyingly poor. Herein, we report a case of a patient with DHL and review the relevant literature.<\/jats:p>","DOI":"10.4137\/ccrep.s11393","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T20:24:06Z","timestamp":1412108646000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Double Hit Lymphoma \u2013 a Case of Unusual Response after Sequential Aggressive Chemotherapy and Review of the Literature"],"prefix":"10.4137","volume":"7","author":[{"given":"Faisal N.","family":"Cheema","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology, Louisiana State University Health Sciences Center, Shreveport, LA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maliha","family":"Agloria","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Louisiana State University Health Sciences Center, Shreveport, LA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nebu","family":"Koshy","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Louisiana State University Health Sciences Center, Shreveport, LA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard C.","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Louisiana State University Health Sciences Center, Shreveport, LA, USA."},{"name":"Division of Hematology and Hematologic Malignancies, University of Utah School of Medicine, Salt Lake City, UT, 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