{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:38:31Z","timestamp":1782603511309,"version":"3.54.5"},"reference-count":77,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Neuromyelitis optica (NMO) is usually a relapsing demyelinating disease of the central nervous system associated with optic neuritis, transverse myelitis involving three or more contiguous spinal cord segments, and seropositivity for NMO-IgG antibody. NMO is often mistaken for multiple sclerosis and there are relatively sporadic publications about NMO and overlapping systemic or organ-specific autoimmune diseases, such as systemic lupus erythematosus (SLE). We described a unique case of a 25-year-old Arab young woman who was diagnosed with SLE, depending on clinical, laboratory investigations and after she had fulfilled the diagnostic criteria for SLE and had presented the following findings: constitutional findings (fatigue, fever, and arthralgia); dermatologic finding (photosensitivity and butterfly rash); chronic renal failure (proteinuria up to 400 mg in 24 hours); hematologic and antinuclear antibodies (positivity for antinuclear factor (ANF), anti-double-stranded DNA antibodies, direct Coombs, ANA and anti-DNA, low C4 and C3, aCL by IgG and IgM). Recently, she presented with several episodes of transverse myelitis and optic neuritis. Clinical, radiological, and laboratory findings especially seropositivity for NMO-IgG were compatible with NMO. Accurate diagnosis is critical to facilitate initiation of immunosuppressive therapy for attack prevention. This case illustrates that NMO may be associated with SLE.<\/jats:p>","DOI":"10.4137\/ccrep.s15177","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T19:04:12Z","timestamp":1401735852000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Systemic Lupus Erythematosus (SLE) Complicated by Neuromyelitis Optica (NMO \u2013 Devic's Disease): Clinic-Pathological Report and Review of the Literature"],"prefix":"10.4137","volume":"7","author":[{"given":"Mohammad","family":"Adawi","sequence":"first","affiliation":[{"name":"Senior Physician Specialist in Rheumatology, Department of Rheumatology; North County Health Services (clalit), Faculty of Medicine in the Galilee, Bar Ilan University, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bishara","family":"Bisharat","sequence":"additional","affiliation":[{"name":"Senior Physician Specialists in Family Medicine, Department of Family Medicine; Faculty of Medicine in the Galilee, Bar Ilan University, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdalla","family":"Bowirrat","sequence":"additional","affiliation":[{"name":"Clinical Neuroscience and Population Genetics; Department of clinical Neuroscience - EMMS Nazareth Hospital, Faculty of Medicine in the Galilee, Bar Ilan University, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,6,2]]},"reference":[{"key":"bibr1-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17551-X"},{"key":"bibr2-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.5.1107"},{"key":"bibr3-CCRep.S15177","first-page":"735486","volume":"2012","author":"Kim W.","year":"2012","journal-title":"Mult Scler Int."},{"key":"bibr4-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.3344\/kjp.2014.27.1.77"},{"key":"bibr5-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70133-3"},{"key":"bibr6-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-7169-7"},{"key":"bibr7-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-10-8"},{"key":"bibr8-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2012.06.002"},{"key":"bibr9-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2012.12.022"},{"key":"bibr10-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-0009-0"},{"key":"bibr11-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0781-2"},{"key":"bibr12-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03529.x"},{"key":"bibr13-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2012.314"},{"key":"bibr14-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182190f74"},{"key":"bibr15-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-004-0342-0"},{"key":"bibr16-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4680(02)00053-6"},{"key":"bibr17-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d31e35"},{"key":"bibr18-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-14"},{"key":"bibr19-CCRep.S15177","first-page":"899","volume":"26","author":"Nair K.R.","year":"1978","journal-title":"J Assoc Physicians India."},{"key":"bibr20-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(02)00043-6"},{"key":"bibr21-CCRep.S15177","first-page":"463","volume":"129","author":"Contamin F.","year":"1978","journal-title":"Ann Med Interne."},{"key":"bibr22-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1979.00500460077012"},{"key":"bibr23-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100036064"},{"key":"bibr24-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1007\/BF00862972"},{"key":"bibr25-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.9.1142"},{"key":"bibr26-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.2.191"},{"key":"bibr27-CCRep.S15177","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.4.470"},{"key":"bibr28-CCRep.S15177","unstructured":"OsterJ.M. 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