{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:48:18Z","timestamp":1777693698057,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Medicine: Case Reports"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p>During esophageal acid clearance, salivation plays an important role in defending the esophageal mucosa. Nizatidine, a histamine H2 receptor antagonist, inhibits acetylcholine esterase, with a resultant increase in acetylcholine. We experienced a patient with gastroesophageal reflux disease (GERD) and impaired salivary secretion who has been successfully treated with nizatidine.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>A 63-year-old female visited our hospital with complaints of heartburn and continuous laryngeal discomfort. Saliva scintigraphy was performed to evaluate the salivary function. Washout ratio was decreased to be 25%\u201340% in individual salivary gland. After the treatment with nizatidine, salivary scintigraphy demonstrated the increased washout ratios. The values of both parotid glands increased up to 90%, whereas those of submandibular glands improved to be around a normal range. GERD symptoms disappeared completely after treatment. In conclusion, nizatidine may be one of therapeutic options for low salivary excretion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4137\/ccrep.s870","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T12:08:55Z","timestamp":1507810135000},"source":"Crossref","is-referenced-by-count":0,"title":["Nizatidine Improves Impaired Salivary Secretion in GERD"],"prefix":"10.4137","volume":"1","author":[{"given":"Yoshihisa","family":"Urita","sequence":"first","affiliation":[{"name":"Department of General Medicine and Emergency Care, Toho University, Tokyo, Japan."},{"name":"Division of Gastroenterology and Hepatology, Toho University, Tokyo, Japan."},{"name":"Department of Hematology, Toho University, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyasu","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of General Medicine and Emergency Care, Toho University, Tokyo, Japan."},{"name":"Division of Gastroenterology and Hepatology, Toho University, Tokyo, Japan."},{"name":"Department of Hematology, Toho University, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Hike","sequence":"additional","affiliation":[{"name":"Department of General Medicine and Emergency Care, Toho University, Tokyo, Japan."},{"name":"Division of Gastroenterology and Hepatology, Toho University, Tokyo, Japan."},{"name":"Department of Hematology, Toho University, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makie","family":"Nanami","sequence":"additional","affiliation":[{"name":"Department of General Medicine and Emergency Care, Toho University, Tokyo, Japan."},{"name":"Division of Gastroenterology and Hepatology, Toho University, Tokyo, Japan."},{"name":"Department of Hematology, Toho University, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of General Medicine and Emergency Care, Toho University, Tokyo, Japan."},{"name":"Division of Gastroenterology and Hepatology, Toho University, Tokyo, Japan."},{"name":"Department of Hematology, Toho University, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of General Medicine and Emergency Care, Toho University, Tokyo, Japan."},{"name":"Division of Gastroenterology and Hepatology, Toho University, Tokyo, Japan."},{"name":"Department of Hematology, Toho University, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asuka","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of General Medicine and Emergency Care, Toho University, Tokyo, Japan."},{"name":"Division of Gastroenterology and Hepatology, Toho University, Tokyo, Japan."},{"name":"Department of Hematology, Toho University, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takamasa","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of General Medicine and Emergency Care, Toho University, Tokyo, Japan."},{"name":"Division of Gastroenterology and Hepatology, Toho University, Tokyo, Japan."},{"name":"Department of Hematology, Toho University, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Domon","sequence":"additional","affiliation":[{"name":"Department of General Medicine and Emergency Care, Toho University, Tokyo, Japan."},{"name":"Division of Gastroenterology and Hepatology, Toho University, Tokyo, Japan."},{"name":"Department of Hematology, Toho University, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of General Medicine and Emergency Care, Toho University, Tokyo, Japan."},{"name":"Division of Gastroenterology and Hepatology, Toho University, Tokyo, Japan."},{"name":"Department of Hematology, Toho University, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Sanaka","sequence":"additional","affiliation":[{"name":"Department of General Medicine and Emergency Care, Toho University, Tokyo, Japan."},{"name":"Division of Gastroenterology and Hepatology, Toho University, Tokyo, Japan."},{"name":"Department of Hematology, Toho University, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of General Medicine and Emergency Care, Toho University, Tokyo, Japan."},{"name":"Division of Gastroenterology and Hepatology, Toho University, Tokyo, Japan."},{"name":"Department of Hematology, Toho University, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motonobu","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of General Medicine and Emergency Care, Toho University, Tokyo, Japan."},{"name":"Division of Gastroenterology and Hepatology, Toho University, Tokyo, Japan."},{"name":"Department of Hematology, Toho University, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,8,19]]},"reference":[{"issue":"1","key":"bibr1-CCRep.S870","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1097\/00042737-200101000-00002","volume":"13","author":"Holtmann G.","year":"2001","journal-title":"Eur. 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