{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:57:23Z","timestamp":1777694243564,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2012,1]]},"abstract":"\n Introduction<\/jats:title>\n Pituitary tumors from lactotrope cells account for about 40% of all functioning pituitary cancers. Men tend to present with a larger, more invasive and rapid growth prolactinomas than women, possibly because hypogonadism features are less evident.<\/jats:p>\n <\/jats:sec>\n \n Case report<\/jats:title>\n A 27-year-old, previously asymptomatic Saudi man presented with a 3-day history of emesis with severe left-sided frontal headache, left face and right upper limb numbness, with signs of obstructive hydrocephalus. Brain Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) revealed a giant pituitary mass occupying several regions (sellar, infra-sellar, and supra-sellar) measuring 6.5 \u00d7 5.7 \u00d7 5.9 cm, and invading the sphenoid sinus as well as the cavernous sinuses bilaterally, with intra-pituitary hemorrhage compressing the third ventricle causing obstructive hydrocephalus. Prolactin levels were> 200,000 mIU\/L, consistent with invasive giant prolactinoma (IGP). He was treated with Cabergoline which eventually normalized the prolactin level and significantly reduced the size of IGP.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This is a rare case of obstructive hydrocephalus with super-imposed intra-pituitary hemorrhage secondary to IGP, highlighting the importance of a full hormonal assessment for proper diagnosis and management.<\/jats:p>\n <\/jats:sec>","DOI":"10.4137\/ccrep.s9675","type":"journal-article","created":{"date-parts":[[2012,7,17]],"date-time":"2012-07-17T09:30:15Z","timestamp":1342517415000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Obstructive Hydrocephalus, Fifth Nerve and Hypothalamus Involvement: Acute Presentation of a Giant Prolactinoma"],"prefix":"10.4137","volume":"5","author":[{"given":"Shadin","family":"Alkatari","sequence":"first","affiliation":[{"name":"King Saud University, King Khalid University Hospital, Medicine Department Endocrine Division."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naji","family":"Aljohani","sequence":"additional","affiliation":[{"name":"Specialized Diabetes and Endocrine Center, King Fahad Medical City, Riyadh, Saudi Arabia."},{"name":"FOM, KSAU-HC, Riyadh, Saudi Arabia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,7,16]]},"reference":[{"key":"bibr1-CCRep.S9675","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1994.80.2.0209"},{"key":"bibr2-CCRep.S9675","first-page":"2102","volume":"82","author":"Delgrange E.","year":"1997","journal-title":"J Clin Endocrinol Metab."},{"key":"bibr3-CCRep.S9675","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197703172961103"},{"key":"bibr4-CCRep.S9675","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198012253032605"},{"key":"bibr5-CCRep.S9675","first-page":"53","volume-title":"Diagnosis and treatment of pituitary Tumors","author":"Hollenhorst R.W.","year":"1973"},{"key":"bibr6-CCRep.S9675","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)65126-4"},{"key":"bibr7-CCRep.S9675","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.97.2.0299"},{"key":"bibr8-CCRep.S9675","first-page":"50","volume":"8","author":"Muralidhara K.S.","year":"2004","journal-title":"Endocrine Abstracts."},{"key":"bibr9-CCRep.S9675","doi-asserted-by":"publisher","DOI":"10.1007\/BF03343743"},{"key":"bibr10-CCRep.S9675","first-page":"2190","volume":"80","author":"Maccagnan P.","year":"1995","journal-title":"J Clin Endocrinol Metab."},{"key":"bibr11-CCRep.S9675","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.97.2.0299"},{"key":"bibr12-CCRep.S9675","first-page":"1","volume":"24","author":"Acharya S.V.","year":"2009","journal-title":"Endocr Pract."},{"key":"bibr13-CCRep.S9675","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01770.x"},{"key":"bibr14-CCRep.S9675","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.104.1.54"},{"key":"bibr15-CCRep.S9675","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-06-0646"}],"container-title":["Clinical Medicine Insights: Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4137\/CCRep.S9675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4137\/CCRep.S9675","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4137\/CCRep.S9675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:14:44Z","timestamp":1777454084000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4137\/CCRep.S9675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":15,"alternative-id":["10.4137\/CCRep.S9675"],"URL":"https:\/\/doi.org\/10.4137\/ccrep.s9675","relation":{},"ISSN":["1179-5476","1179-5476"],"issn-type":[{"value":"1179-5476","type":"print"},{"value":"1179-5476","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1]]},"article-number":"CCRep.S9675"}}