{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:41:29Z","timestamp":1780490489694,"version":"3.54.1"},"reference-count":54,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Gastroenterol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is increased interest in combining nutritional modalities with pharmacological therapies for managing patients with diarrhea-predominant IBS (IBS-D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>A randomized, double-blind, placebo-controlled study to evaluate the impact of oral serum-derived bovine immunoglobulin\/protein isolate (SBI) on gastrointestinal symptom scores and quality of life (QoL) in subjects with IBS-D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Study subjects previously diagnosed with IBS-D according to ROME II criteria were recruited from London, Ontario, Canada and assigned to receive 5 g\/day SBI, 10 g\/day SBI, or placebo for 6 weeks. Daily symptom frequency and severity scores and a modified IBS-36 questionnaire assessed the impact of nutritional intervention. Laboratory assessments were performed at screening and end of treatment (EOT) to evaluate safety. Within-group comparisons of changes in number of days per week with symptoms and symptom severity were conducted on the per-protocol population of subjects using a t-test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Subjects who received SBI at 10 g\/day (N = 15) had statistically significant within-group reductions in abdominal pain (p &lt; 0.01), loose stools (p &lt; 0.01), bloating (p &lt; 0.05), flatulence (p &lt; 0.01), urgency (p &lt; 0.05) and any symptom (p &lt; 0.01) at EOT vs. baseline. Subjects receiving 5 g\/day of SBI (N = 15) realized statistically significant within-group reductions in days with flatulence (p &lt; 0.035), incomplete evacuation (p &lt; 0.05), and any symptom (p &lt; 0.01). There were no significant changes in QoL scores or in hematology or clinical chemistry among treatment groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This pilot study showed that nutritional therapy with either 10 g\/day or 5 g\/day of SBI in 30 patients was well tolerated and resulted in statistically significant within group improvements in both symptom days and in daily symptom scores in subjects with IBS-D. Additional studies are underway with larger numbers of subjects to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4137\/cgast.s13200","type":"journal-article","created":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T15:00:42Z","timestamp":1386255642000},"page":"CGast.S13200","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":52,"title":["Evaluation of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects with Diarrhea-Predominant Irritable Bowel Syndrome"],"prefix":"10.4137","volume":"6","author":[{"given":"Dale","family":"Wilson","sequence":"first","affiliation":[{"name":"Department of Family Medicine, University of Western Ontario, London, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malkanthi","family":"Evans","sequence":"additional","affiliation":[{"name":"KGK Synergize Inc., London, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Weaver","sequence":"additional","affiliation":[{"name":"EnteraHealth, Inc, Cary, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey L.","family":"Shaw","sequence":"additional","affiliation":[{"name":"EnteraHealth, Inc, Cary, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald L.","family":"Klein","sequence":"additional","affiliation":[{"name":"EnteraHealth, Inc, Cary, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,12,5]]},"reference":[{"key":"bibr1-CGast.S13200","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"issue":"8","key":"bibr2-CGast.S13200","first-page":"1910","volume":"97","author":"Saito Y.A.","year":"2002","journal-title":"Am J 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