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H. pylori presents a high-level of genetic diversity, which can be an important factor in its adaptation to the host stomach and also for the clinical outcome of infection. There are important H. pylori virulence factors that, along with host characteristics and the external environment, have been associated with the different occurrences of diseases. This review is aimed to analyzing and summarizing the main of them and possible associations with the clinical outcome.<\/jats:p>","DOI":"10.4137\/cgast.s13760","type":"journal-article","created":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T16:36:28Z","timestamp":1395938188000},"page":"CGast.S13760","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":131,"title":["Virulence Factors of\n                    <i>Helicobacter pylori:<\/i>\n                    A Review"],"prefix":"10.4137","volume":"7","author":[{"given":"Bruna M.","family":"Roesler","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, S\u00e3o Paulo, Brazil."},{"name":"Center of Diagnosis of Digestive Diseases, Faculty of Medical Sciences, State University of Campinas, Campinas, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.A.","family":"Rabelo-Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, S\u00e3o Paulo, Brazil."},{"name":"Center of Diagnosis of Digestive Diseases, Faculty of Medical Sciences, State University of Campinas, Campinas, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.R.","family":"Zeitune","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, S\u00e3o Paulo, Brazil."},{"name":"Center of Diagnosis of Digestive Diseases, Faculty of Medical Sciences, State University of Campinas, Campinas, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,3,27]]},"reference":[{"key":"bibr1-CGast.S13760","doi-asserted-by":"publisher","DOI":"10.1007\/BF01969526"},{"key":"bibr2-CGast.S13760","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91816-6"},{"key":"bibr3-CGast.S13760","doi-asserted-by":"publisher","DOI":"10.1126\/science.1166083"},{"key":"bibr4-CGast.S13760","doi-asserted-by":"publisher","DOI":"10.1126\/science.1080857"},{"key":"bibr5-CGast.S13760","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020542"},{"key":"bibr6-CGast.S13760","doi-asserted-by":"publisher","DOI":"10.1172\/JCI20925"},{"key":"bibr7-CGast.S13760","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12191"},{"key":"bibr8-CGast.S13760","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e32835b69aa"},{"key":"bibr9-CGast.S13760","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1328"},{"key":"bibr10-CGast.S13760","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i9.2021"},{"key":"bibr11-CGast.S13760","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2009.00677.x"},{"key":"bibr12-CGast.S13760","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00054-05"},{"key":"bibr13-CGast.S13760","unstructured":"International Agency for Research on Cancer. 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