{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:44:37Z","timestamp":1778651077172,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Gastroenterol"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We evaluated the effect of Helicobacter pylori (HP) eradication on p53, cyclin D1 expression, and cell proliferation in gastric mucosa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We assessed p53, cyclin D1, and ki67 immunoexpression in gastric mucosa from 31 HP chronic gastritis patients and 12 controls. Reassessment was performed 6 months after successful HP eradication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Successful eradication resulted in significant decrease of p53 (1.53 \u00b1 0.16 vs 0.83 \u00b1 0.19, P = 0.01) and ki67 (9.84 \u00b1 0.96 vs 4.77 \u00b1 0.27, P &lt; 0.001) staining in the antrum. Similarly, p53 immunoreactivity significantly decreased in the corpus (1.27 \u00b1 0.20 vs 0.46 \u00b1 0.15, P = 0.02), while there was a trend for decreased corpus cyclin D1 and ki67 expression (0.17 \u00b1 0.07 vs 0.0, P = 0.08 and 8.71 \u00b1 1.24 vs 5.85 \u00b1 0.54, P = 0.09, respectively). Importantly, after successful HP eradication, the immunoreactivity of the studied parameters was similar to that of controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Successful HP infection eradication restores p53, cyclin D1, and ki67 immunoreactivity in the gastric mucosa to the level of controls.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4137\/cgast.s38330","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T16:03:14Z","timestamp":1479398594000},"page":"CGast.S38330","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Eradication of\n                    <i>Helicobacter pylori<\/i>\n                    Infection Restores ki67, p53, and Cyclin D1 Immunoreactivity in the Human Gastric Epithelium"],"prefix":"10.4137","volume":"9","author":[{"given":"Konstantinos","family":"Triantafyllou","sequence":"first","affiliation":[{"name":"Hepatogastroenterology Unit, Second Department of Internal Medicine\u2014Propaedeutic, Research Institute and Diabetes Center, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasilios","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Hepatogastroenterology Unit, Second Department of Internal Medicine\u2014Propaedeutic, Research Institute and Diabetes Center, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodoras","family":"Emanouil","sequence":"additional","affiliation":[{"name":"Hepatogastroenterology Unit, Second Department of Internal Medicine\u2014Propaedeutic, Research Institute and Diabetes Center, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paraskevas","family":"Gkolfakis","sequence":"additional","affiliation":[{"name":"Hepatogastroenterology Unit, Second Department of Internal Medicine\u2014Propaedeutic, Research Institute and Diabetes Center, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasileia","family":"Damaskou","sequence":"additional","affiliation":[{"name":"Second Department of Pathology Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Tziatzios","sequence":"additional","affiliation":[{"name":"Hepatogastroenterology Unit, Second Department of Internal Medicine\u2014Propaedeutic, Research Institute and Diabetes Center, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis G.","family":"Panayiotides","sequence":"additional","affiliation":[{"name":"Second Department of Pathology Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Vafiadis","sequence":"additional","affiliation":[{"name":"Academic Department of Gastroenterology, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spiros D.","family":"Ladas","sequence":"additional","affiliation":[{"name":"Academic Department of Gastroenterology, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,11,17]]},"reference":[{"key":"bibr1-CGast.S38330","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2010.02.040"},{"key":"bibr2-CGast.S38330","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2010.07.014"},{"key":"bibr3-CGast.S38330","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41688.x"},{"key":"bibr4-CGast.S38330","doi-asserted-by":"publisher","DOI":"10.1002\/humu.10180"},{"key":"bibr5-CGast.S38330","doi-asserted-by":"publisher","DOI":"10.1097\/01.MPG.0000148832.22130.D7"},{"key":"bibr6-CGast.S38330","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-6-24"},{"key":"bibr7-CGast.S38330","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000093626.15701.76"},{"key":"bibr8-CGast.S38330","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90140-6"},{"key":"bibr9-CGast.S38330","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2015.04.003"},{"key":"bibr10-CGast.S38330","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"bibr11-CGast.S38330","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.101634"},{"key":"bibr12-CGast.S38330","doi-asserted-by":"publisher","DOI":"10.1038\/nature13480"},{"key":"bibr13-CGast.S38330","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-016-0754-8"},{"key":"bibr14-CGast.S38330","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2001.00003.x"},{"key":"bibr15-CGast.S38330","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/108.1.26"},{"issue":"59","key":"bibr16-CGast.S38330","first-page":"1531","volume":"51","author":"Demiray 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