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At this stage, it often causes severe morbidity due to pathological fracture and\/or metastatic epidural spinal cord compression which, if untreated, inevitably leads to intractable pain, neurological deficit, and paralysis. Unfortunately, the underlying molecular mechanisms driving growth of secondary PC in the bony vertebral column remain largely unknown. Further investigation is warranted in order to identify therapeutic targets in the future. This review summarizes the current understanding of PC bone metastasis in the spine, highlighting interactions between key tumor and bone-derived factors which influence tumor progression, especially the functional roles of osteoblasts and osteoclasts in the bone microenvironment through their interactions with metastatic PC cells and the critical pathway RANK\/RANKL\/OPG in bone destruction. <\/jats:p>","DOI":"10.4137\/cgm.s12769","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T22:30:17Z","timestamp":1385591417000},"page":"CGM.S12769","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["The Osteoblastic and Osteoclastic Interactions in Spinal Metastases Secondary to Prostate Cancer"],"prefix":"10.4137","volume":"6","author":[{"given":"Sathana","family":"Dushyanthen","sequence":"first","affiliation":[{"name":"Spinal Biology Research Laboratory, Department of Spinal Surgery, University of Melbourne Department of Surgery, Austin Health, Heidelberg Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davina A.F.","family":"Cossigny","sequence":"additional","affiliation":[{"name":"Spinal Biology Research Laboratory, Department of Spinal Surgery, University of Melbourne Department of Surgery, Austin Health, Heidelberg Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald M.Y.","family":"Quan","sequence":"additional","affiliation":[{"name":"Spinal Biology Research Laboratory, Department of Spinal Surgery, University of Melbourne Department of Surgery, Austin Health, Heidelberg Victoria, 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