{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:35:29Z","timestamp":1777397729950,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med\ufffdInsights\ufffdArthritis\ufffdMusculoskelet Disord"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim of the Work<\/jats:title>\n                    <jats:p>This study investigates whether serum and urinary interleukin-6 (IL-6) represent an early marker of kidney involvement and assesses the difference between them and renal biopsy in lupus nephritis (LN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>A total of 60 systemic lupus erythematosus (SLE) patients were compared to 20 healthy controls. Urinary and serum IL-6 were measured in both patients and controls. In addition, renal biopsy was done prior or shortly after urine and blood sampling; the results were classified according to the International Society of Nephrology\/Renal Pathology Society classification of LN by recording the activity score and chronicity score for each sample.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was a significant higher level of urinary IL-6 in the SLE patients with biopsy-proven LN than in those without LN and those of the control group. However, no significant difference was reported between the three groups as regards serum IL-6. A strong positive correlation was found between urinary IL-6 and renal disease activity based on the renal SLE disease activity index (SLEDAI) score with no significant correlation regarding the extra renal SLEDAI. Urinary IL-6 was positively correlated with renal biopsy results and with its activity scores but weakly correlated with the chronicity scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Urinary IL-6 may provide a simple noninvasive potential marker of disease activity of renal involvement in adult patients with SLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4137\/cmamd.s32269","type":"journal-article","created":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T16:06:18Z","timestamp":1457366778000},"page":"CMAMD.S32269","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Serum and Urinary Interleukin-6 in Assessment of Renal Activity in Egyptian Patients with Systemic Lupus Erythematosus"],"prefix":"10.4137","volume":"9","author":[{"given":"Rawhya R.","family":"EL-Shereef","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Rehabilitation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Lotfi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Rehabilitation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emad A.","family":"Abdel-Naeam","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba","family":"Tawfik","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Faculty of Medicine, Minia University, Minia, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,3,7]]},"reference":[{"key":"bibr1-CMAMD.S32269","doi-asserted-by":"publisher","DOI":"10.1002\/art.21224"},{"key":"bibr2-CMAMD.S32269","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-374994-9.10036-1"},{"key":"bibr3-CMAMD.S32269","first-page":"849684","volume":"2012","author":"de Zubiria Salgado A.","year":"2012","journal-title":"Autoimmune 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