{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:34:41Z","timestamp":1777397681862,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med\ufffdInsights\ufffdArthritis\ufffdMusculoskelet Disord"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dupuytren's contracture (DC) and HFE hemochromatosis occur in some of the same at-risk populations and present with similar comorbid conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We estimated DC prevalence in two cohorts of white Alabama hemochromatosis probands (294 C282Y homozygotes, 67 C282Y\/H63D compound heterozygotes) in a retrospective study. We performed logistic regressions on DC using the following independent variables: age, body mass index, heavy ethanol consumption, serum ferritin, elevated serum AST\/ALT, non-alcoholic fatty liver disease, viral hepatitis, cirrhosis, and diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One man and two women with C282Y homozygosity had DC (prevalence 1.02%; 95% CI 0.35%\u20132.96%). A man with C282Y\/H63D had DC (prevalence 1.49%; 95% CI 0.26%\u20137.98%). DC occurred as an autosomal dominant trait in his kinship. In regression analyses, no single variable predicted DC. We observed no new DC cases after the diagnosis of hemochromatosis (mean follow-up 12.9 \u00b1 7.5 years (1 SD), and 9.0 \u00b15.1 years, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our prevalence estimates of DC in white Alabama hemochromatosis probands are similar to those found in the white US population cohorts. DC risk was unrelated to the variables we studied.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4137\/cmamd.s9935","type":"journal-article","created":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T18:14:42Z","timestamp":1345572882000},"page":"CMAMD.S9935","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Dupuytren's Contracture in Alabama\n                    <i>HFE<\/i>\n                    Hemochromatosis Probands"],"prefix":"10.4137","volume":"5","author":[{"given":"James C.","family":"Barton","sequence":"first","affiliation":[{"name":"Southern Iron Disorders Center, Birmingham, Alabama, USA."},{"name":"Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Clayborn","family":"Barton","sequence":"additional","affiliation":[{"name":"Southern Iron Disorders Center, Birmingham, Alabama, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,8,21]]},"reference":[{"key":"bibr1-CMAMD.S9935","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200701000-00026"},{"issue":"5","key":"bibr2-CMAMD.S9935","first-page":"288","volume":"64","author":"Tyrkko J.","year":"1975","journal-title":"Ann Chir Gynaecol 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