{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T20:32:40Z","timestamp":1779395560619,"version":"3.53.1"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Cardiol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Rheumatic heart disease (RHD) affects heart-valve tissue and is the most serious consequence of group A Streptococcus infection. Myxomatous degeneration (MXD) is the most frequent valvopathy in the western world. In the present work, key protein expression alterations in the heart-valve tissue of RHD and MXD patients were identified and characterized, with controls from cadaveric organ donors. Proteins were separated by two-dimensional (2D)-electrophoresis and identified by mass spectrometry. We found 17 differentially expressed protein spots, as compared to control samples. We observed an increased expression of ASAP-2 in the RHD patients\u2019 valves, while collagen-VI, haptoglobin-related protein, prolargin, and cartilage oligomeric protein showed reduced expression. Valve tissue of MXD patients, on the other hand, presented lower expression of annexin-Al and A2, septin-2, SOD (Cu\/Zn), and transgelin. Tissue samples from both valvopathies displayed higher expression of apolipoprotein-Al. Biglycan was downexpressed in both diseases. Vimentin and lumican showed higher expression in RHD and lower in MXD. These results suggest that key pathogenetic mechanisms are intrinsically distinct in RHD and MXD.<\/jats:p>","DOI":"10.4137\/cmc.s17622","type":"journal-article","created":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T18:51:46Z","timestamp":1409165506000},"page":"CMC.S17622","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Distinct Mitral Valve Proteomic Profiles in Rheumatic Heart Disease and Myxomatous Degeneration"],"prefix":"10.4137","volume":"8","author":[{"given":"Carlo","family":"De Oliveira Martins","sequence":"first","affiliation":[{"name":"Heart Institute (INCOR), School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Institute of Investigation in Immunology, National Institute for Science and Technology, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keity Souza","family":"Santos","sequence":"additional","affiliation":[{"name":"Heart Institute (INCOR), School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Institute of Investigation in Immunology, National Institute for Science and Technology, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico Moraes","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Heart Institute (INCOR), School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Institute of Investigation in Immunology, National Institute for Science and Technology, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Camillo","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Heart Institute (INCOR), School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Pharma Research and Early Development, F. 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