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The role of LDL-C is well established and statins have proved effective drugs, although the relative risk reduction is only around 30%. The importance of other factors\u2014notably low HDL-C and high TGs\u2014has become increasingly clear and the search for alternative strategies continues. Niacin is particularly effective in achieving normalization of HDL-C but is clinically underutilized due to the side effect of cutaneous flushing. The discovery that flushing is mediated by mechanisms distinct from the lipid-lowering effects has led to the development of combination drugs with reduced side effects. This review considers the evidence regarding the clinical efficacy of extended-release niacin and the DP1 antagonist laropiprant in the treatment of hypercholesterolemia and mixed dyslipidemias.<\/jats:p>","DOI":"10.4137\/cmc.s7601","type":"journal-article","created":{"date-parts":[[2011,9,19]],"date-time":"2011-09-19T18:16:46Z","timestamp":1316456206000},"page":"CMC.S7601","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Extended Release Niacin-Laropiprant in Patients with Hypercholesterolemia or Mixed Dyslipidemias Improves Clinical Parameters"],"prefix":"10.4137","volume":"5","author":[{"given":"Helen","family":"Vosper","sequence":"first","affiliation":[{"name":"School of Pharmacy and Life Sciences, Robert Gordon University, Schoolhill, Aberdeen, AB10 1FR, Scotland, 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