{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:49:05Z","timestamp":1777499345340,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Cardiol"],"published-print":{"date-parts":[[2012,1]]},"abstract":"\n Background<\/jats:title>\n \n In neonates, the increase in O\n 2<\/jats:sub>\n -delivery (DO\n 2<\/jats:sub>\n ) by dopamine is offset by a greater increase in O\n 2<\/jats:sub>\n -consumption (VO\n 2<\/jats:sub>\n ). This has been attributed to \u03b2\n 3<\/jats:sub>\n -adrenergic receptors in neonatal brown fat tissue. \u03b2\n 3<\/jats:sub>\n receptors in the heart have negative inotropic properties. We evaluated the effects of SR59230A, a \u03b2\n 3<\/jats:sub>\n -antagonist, on the balance of systemic and myocardial O\n 2<\/jats:sub>\n -transport in newborn lambs treated with dopamine.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Lambs (2-5 days old, n = 12) were anesthetized and mechanically ventilated. Heart rate (HR) and rectal temperature were monitored. VO\n 2<\/jats:sub>\n was measured by respiratory mass spectrometry and cardiac output (CO) by a pulmonary artery transonic flowmeter. Arterial, jugular bulb venous and coronary sinus blood gases and lactate were measured to calculate DO\n 2<\/jats:sub>\n , O\n 2<\/jats:sub>\n extraction ratio (ERO\n 2<\/jats:sub>\n ), myocardial O\n 2<\/jats:sub>\n and lactate extraction ratios (mERO\n 2<\/jats:sub>\n , mERlac). After baseline measurements, lambs were randomized to receive SR59230A at 5 mg\/kg iv (SRG) or placebo. Both groups received incremental doses of a dopamine infusion (0-5-10-15-20 mcg\/kg\/min) every 15 min. Measurements were repeated at the end of each dose.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n After SR59230A infusion, CO and HR trended to decrease ( P = 0.06), but no significant changes occurred in other parameters. Over the incremental doses of dopamine, temperature increased in both groups ( P < 0.0001) but to a lesser degree in SRG ( P = 0.004). CO and HR increased ( P = 0.005 and 0.04) and similarly in both groups ( P > 0.1). DO\n 2<\/jats:sub>\n trended to a small increase ( P = 0.08). VO\n 2<\/jats:sub>\n increased in both groups ( P < 0.0001) but to a lesser degree in SRG ( P < 0.0001). As a result, ERO\n 2<\/jats:sub>\n increased in both groups ( P < 0.0001), but to a lesser degree in SRG ( P < 0.0001). mERO\n 2<\/jats:sub>\n was lower in SRG ( P = 0.01) with a faster increase ( P < 0.0001). mERlac was higher in SRG ( P = 0.06) with a faster decrease ( P = 0.04).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Although SR59230A tends to induce an initial drop in CO, it significantly attenuates the rise in VO\n 2<\/jats:sub>\n and hence the imbalance of systemic and myocardial O\n 2<\/jats:sub>\n transport induced by dopamine at higher doses. Studies are warranted to examine the effect of SR59230A in cases of cardiac dysfunction and increased VO\n 2<\/jats:sub>\n , observed after cardiac surgery.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4137\/cmc.s8654","type":"journal-article","created":{"date-parts":[[2012,2,16]],"date-time":"2012-02-16T15:43:22Z","timestamp":1329407002000},"page":"CMC.S8654","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["\u03b2\n 3<\/sub>\n -Adrenoceptor Antagonist SR59230A Attenuates the Imbalance of Systemic and Myocardial Oxygen Transport Induced by Dopamine in Newborn Lambs"],"prefix":"10.4137","volume":"6","author":[{"given":"Richdeep S.","family":"Gill","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Alberta, Edmonton, Alberta."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Yin","family":"Cheun","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Alberta, Edmonton, Alberta."},{"name":"Department of Pediatrics, University of Alberta, Edmonton, Alberta."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alberta, Edmonton, Alberta."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Al","family":"Aklabi","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Alberta, Edmonton, Alberta."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeevan","family":"Nagendran","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Alberta, Edmonton, Alberta."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis G.","family":"Quinonez","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Alberta, Edmonton, Alberta."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying Qian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alberta, Edmonton, Alberta."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Alberta, Edmonton, Alberta."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Alberta, Edmonton, Alberta."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan M.","family":"Rebeyka","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Alberta, Edmonton, Alberta."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alberta, Edmonton, Alberta."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,2,16]]},"reference":[{"key":"bibr1-CMC.S8654","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196612222752501"},{"key":"bibr2-CMC.S8654","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/7.4.438"},{"key":"bibr3-CMC.S8654","doi-asserted-by":"publisher","DOI":"10.1007\/s001340101044"},{"key":"bibr4-CMC.S8654","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/69.3.298"},{"key":"bibr5-CMC.S8654","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198711000-00011"},{"key":"bibr6-CMC.S8654","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.038"},{"key":"bibr7-CMC.S8654","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.04.003"},{"key":"bibr8-CMC.S8654","doi-asserted-by":"publisher","DOI":"10.1002\/med.2610130604"},{"key":"bibr9-CMC.S8654","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.273.4.C1136"},{"key":"bibr10-CMC.S8654","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(85)90165-7"},{"key":"bibr11-CMC.S8654","first-page":"409","volume":"7","author":"Tan 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